[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592431":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":30,"locations":30,"responsibleParty":37,"collaborators":30,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":30,"eligibilityCriteria":47,"healthyVolunteers":43,"sex":48,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":30,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":30,"overallStatus":60,"whyStopped":30,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":30},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"35% Topical Bromelain in Orabase","EXPERIMENTAL","Participants in this group will receive 35% bromelain gel incorporated into an orabase adhesive medium.",[13],"Dietary Supplement: 35% Topical Bromelain in Orabase",{"label":15,"type":10,"description":16,"interventionNames":17},"50% Topical Bromelain in Orabase","Participants assigned to this group will be treated with 50% bromelain gel formulated in orabase.",[18],"Dietary Supplement: 50% Topical Bromelain in Orabase",{"label":20,"type":21,"description":22,"interventionNames":23},"0.1% Topical Triamcinolone Acetonide in Orabase","ACTIVE_COMPARATOR","This group will receive the standard treatment of 0.1% triamcinolone acetonide in orabase, commonly used for managing Recurrent Aphthous Stomatitis.",[24],"Drug: 0.1% Topical Triamcinolone Acetonide in Orabase",[26,31,33],{"type":27,"name":9,"description":28,"armGroupLabels":29,"otherNames":30},"DIETARY_SUPPLEMENT","Bromelain is a natural proteolytic enzyme derived from pineapple, recognized for its broad range of pharmacological properties. It exhibits significant anti-inflammatory effects by reducing edema. In addition to its anti-inflammatory activity, bromelain possesses antioxidant and analgesic properties.",[9],null,{"type":27,"name":15,"description":28,"armGroupLabels":32,"otherNames":30},[15],{"type":34,"name":20,"description":35,"armGroupLabels":36,"otherNames":30},"DRUG","Triamcinolone acetonide in orabase, a corticosteroid-based standard treatment for Recurrent Aphthous Stomatitis (RAS), is used for its strong anti-inflammatory and immunosuppressive effects. In this study, it serves as the conventional treatment against the novel therapy",[20],{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Omnia Ahmed Ayoub Mohamed","Master's Student in Oral Medicine","100592431","phase-2-effect-of-topical-bromelain-versus-topical-corticosteroids-in-the-management-of-recurrent-aphthous-stomatitis-100592431",false,"NCT06993337","Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Recurrent Aphthous Stomatitis","Evaluation of Topical Bromelain Versus Topical Corticosteroids in Management of Recurrent Aphthous Stomatitis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18-60 years.\n* Diagnosed with RAS.\n* Onset of ulcer within the last 48 hours.\n* Willingness to participate and provide informed consent.\n\nExclusion Criteria:\n\n* History of hematological deficiencies, GIT disorders, Behcet's disease and major systemic diseases.\n* Pregnant or breastfeeding patients.\n* Previous treatment for the current ulcer episode.","ALL","18 Years","60 Years",{"count":52,"type":53},63,"ESTIMATED","INTERVENTIONAL",[56],"PHASE2","Bromelain, a natural product, exhibits anti-inflammatory, immunomodulatory, and wound-healing properties. However, its efficacy in treating oral mucosal ulcers remains unexplored. This study aims to evaluate the effect of bromelain as a safe alternate for management of RAS.",[59],"Recurrent Aphthous Stomatitis","NOT_YET_RECRUITING","2025-05-25",{"date":63,"type":64},"2025-05-28","ACTUAL",{"date":66,"type":53},"2025-06-15",{"date":68,"type":53},"2026-06-15",{"name":5,"class":6}]