[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586463":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":36,"locations":46,"responsibleParty":75,"collaborators":77,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":82,"sex":88,"minAge":89,"maxAge":26,"enrollmentInfo":90,"targetDuration":26,"studyType":93,"phases":94,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":49,"whyStopped":26,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"University of Guadalajara","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention group","ACTIVE_COMPARATOR","Treated with conventional synthetic FARMEs (Metrotexato, Hydroxychloroquine, Leflunomide, Sulfasalazina and their combinations) plus vitamin E 800mg\u002Fday.",[13],"Dietary Supplement: Will take vitamin E 800mg\u002Fday",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","PLACEBO_COMPARATOR","Treated with conventional synthetic FARMEs (Metrotexato, Hydroxychloroquine, Leflunomide, Sulfasalazina and their combinations) plus the consumption of magnesium oxide 200mg\u002Fday in placebo form.",[19],"Drug: Will take 200mg\u002Fday magnesium oxide placebo.",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Will take vitamin E 800mg\u002Fday","Patients with deficient vitamin E intake (\\\u003C15mg\u002Fday), who are treated with conventional synthetic FARMEs (Metrotexato, Hydroxychloroquine, Leflunomide, Sulfasalazina and their combinations) plus vitamin E 800mg\u002Fday.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"DRUG","Will take 200mg\u002Fday magnesium oxide placebo.","Patients with RA deficient in vitamin E intake (\\\u003C15mg\u002Fday) , who are treated with conventional synthetic FARMEs (Metrotexato, Hydroxychloroquine, Leflunomide, Sulfasalazina and their combinations) plus the consumption of magnesium oxide 200mg\u002Fday in placebo form.",[15],[33],{"name":34,"affiliation":5,"role":35},"Christian Johana J Baños Hernández, D.Sc.","PRINCIPAL_INVESTIGATOR",[37,42],{"name":34,"role":38,"phone":39,"phoneExt":40,"email":41},"CONTACT","+54 10585200 ó 7471493487","34200","johana.banos@academicos.udg.mx",{"name":43,"role":38,"phone":44,"phoneExt":26,"email":45},"Martin De Leon Cid, B.Nutr.","+54 4931817830","martin.deleon9901@alumnos.udg.mx",[47,68],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Civil Hospital of Guadalajara","RECRUITING","Guadalajara","Jalisco","44280","Mexico","MX",{"type":56,"coordinates":57},"Point",[58,59],-103.34749,20.67738,{"lat":59,"lon":58},[62,65,67],{"name":63,"role":38,"phone":64,"phoneExt":40,"email":41},"Christian Johana J Baños Hernández, D.Sc","+54 10585200",{"name":66,"role":38,"phone":44,"phoneExt":26,"email":45},"Martín De León Cid, B.S. in Nutrition",{"name":63,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":69,"status":70,"city":50,"state":51,"zip":71,"country":53,"countryCode":54,"cosmosGeoPoint":72,"geoPoint":74,"contacts":26},"Universidad de Guadalajara","NOT_YET_RECRUITING","44340",{"type":56,"coordinates":73},[58,59],{"lat":59,"lon":58},{"type":76,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[78],{"name":79,"class":6},"Hospital Civil de Guadalajara","100586463","phase-2-effect-of-vitamin-e--tocopherol-on-clinical-activity-and-inflammation-in-rheumatoid-arthritis-100586463",false,"NCT06915701","\"Effect of Vitamin E (α-Tocopherol) on Clinical Activity and Inflammation in Rheumatoid Arthritis\"","\"Evaluation of the Effect of Vitamin E (α-tocopherol) Supplementation on Clinical Activity and Inflammation in Patients With Rheumatoid Arthritis\"","VitE in RA","Inclusion criteria:\n\n* Female sex\n* RA classification (ACR\u002FEULAR 2010)\n* Early RA 2 years\n* Treatment with conventional synthetic FARMEs (Metrotexato, Hydroxychloroquine, Leflunomide, Sulfasalazina and their combinations)\n* DAS28 ≥3.2\n* Vitamin E intake deficiency (\\\u003C15mg\u002Fday)\n* No comorbidities\n* Age \\> 18 years\n* Voluntary participation and informed consent.\n\nExclusion Criteria:\n\n* Liver and kidney disease\n* Overlap syndrome\n* Coagulation disorders\n* Pregnancy\n* Consumption of supplements (iron, vitamin E, and K), and medications such as acetylsalicylic acid, amlodipine, estrogen, glucocorticoids and drugs used to treat dyslipidemias in the last three months.\n\nElimination Criteria:\n\n* Errors in administration of the 20% supplement\n* Adverse effects of the supplement\n* Pregnancy during the study\n* Insufficient blood sample\n* Voluntary withdrawal of informed consent.","FEMALE","18 Years",{"count":91,"type":92},46,"ESTIMATED","INTERVENTIONAL",[95,96],"PHASE2","PHASE3","The objective of this clinical trial is to determine whether α-tocopherol (vitamin E) supplementation decreases inflammation and clinical activity in patients with rheumatoid arthritis (RA).The main questions to be answered are:\n\n* Is supplementation with vitamin E (α-tocopherol) for one month associated with decreased clinical activity and inflammation in patients with RA?\n\nResearchers will compare α-tocopherol with a placebo (a look-alike substance containing no active ingredient) to see if α-tocopherol effectively reduces inflammation and clinical activity in patients with rheumatoid arthritis.\n\nParticipants will:\n\n* Take two capsules (one in the morning and one in the afternoon) of either α-tocopherol or placebo every day for a month.\n* Attend clinic visits at the start of the intervention (baseline) and at the end of the month for final check-ups and tests.\n* Keep a diary to record your symptoms and how often you take α-tocopherol or placebo.",[99],"Rheumatoid Arthritis",[101,102,103],"Rheumatoid arthritis","Antioxidant","Vitamin E","2026-02-10",{"date":106,"type":107},"2026-02-13","ACTUAL",{"date":109,"type":107},"2026-02-06",{"date":111,"type":92},"2027-01-15",{"name":5,"class":6},2]