[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548727":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":29,"centralContacts":51,"locations":60,"responsibleParty":75,"collaborators":29,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":29,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":29,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":63,"whyStopped":29,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"University of Georgia","OTHER",[8,19],{"label":9,"type":10,"description":11,"interventionNames":12},"MitoQ, then Placebo","EXPERIMENTAL","Participants will be given a single dose of 80mg MitoQ supplement first following an overnight fast. Then they will receive a matched Placebo single dose within a minimum 14 days",[13,14,15,16,17,18],"Dietary Supplement: MitoQ","Dietary Supplement: Placebo","Drug: MitoTempo","Drug: Tempol","Drug: L-NAME","Drug: SNP - Sodium Nitroprusside",{"label":20,"type":10,"description":21,"interventionNames":22},"Placebo, then MitoQ","Participants will be given a single dose of Placebo (matched to 80mg MitoQ) first following an overnight fast. Then they will receive 80mg MitoQ supplement single dose within a minimum of 14 days",[13,14,15,16,17,18],[24,30,34,39,43,47],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"DIETARY_SUPPLEMENT","MitoQ","MitoQ supplement is composed of mitoquinol mesylate, which is a synthetic analog of coenzyme Q10",[9,20],null,{"type":25,"name":31,"description":32,"armGroupLabels":33,"otherNames":29},"Placebo","MitoQ matched Placebo",[9,20],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":29},"DRUG","MitoTempo","During each experimental visit, intradermal microdialysis will be used to locally infuse MitoTempo (a mitochondria-specific superoxide dismutase mimetic) into the cutaneous microvasculature in the ventral aspect of the left forearm.",[9,20],{"type":35,"name":40,"description":41,"armGroupLabels":42,"otherNames":29},"Tempol","During each experimental visit, intradermal microdialysis will be used to locally infuse Tempol (a superoxide dismutase mimetic) into the cutaneous microvasculature in the ventral aspect of the left forearm.",[9,20],{"type":35,"name":44,"description":45,"armGroupLabels":46,"otherNames":29},"L-NAME","During each experimental visit, L-NAME (nitric oxide synthase inhibitor) will be perfused through microdialysis fibers for quantification of nitric oxide-mediated vasodilation.",[9,20],{"type":35,"name":48,"description":49,"armGroupLabels":50,"otherNames":29},"SNP - Sodium Nitroprusside","At the end of each experimental visit, SNP will be perfused through microdialysis fibers to elicit a maximal vasodilation response.",[9,20],[52,57],{"name":53,"role":54,"phone":55,"phoneExt":29,"email":56},"S. Tony Wolf","CONTACT","706-542-4378","stwolf@uga.edu",{"name":58,"role":54,"phone":29,"phoneExt":29,"email":59},"Melissa Gorejena","mgorejena@uga.edu",[61],{"facility":62,"status":63,"city":64,"state":65,"zip":66,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":74,"contacts":29},"Ramsey Student Center, University of Georgia","RECRUITING","Athens","Georgia","30602","United States","US",{"type":70,"coordinates":71},"Point",[72,73],-83.37794,33.96095,{"lat":73,"lon":72},{"type":76,"investigatorFullName":53,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Assistant Professor","100548727","phase-2-effects-of-an-antioxidant-supplement-on-blood-vessel-health-100548727",false,"NCT06424756","Effects of an Antioxidant Supplement on Blood Vessel Health","Role of Mitochondria-derived Oxidative Stress on Microvascular Endothelial Function in Healthy Non-Hispanic Black and White Adults","Inclusion Criteria:\n\n* Self-identify as either non-Hispanic Black or non-Hispanic White.\n* Men and women 18-75 years old.\n* Non-hypertensive (systolic blood pressure \\[SBP\\]\\\u003C130 and diastolic blood pressure \\[DBP\\] \\\u003C85 mmHg).\n* Have low density lipoprotein cholesterol \\\u003C150mg\u002Fdl.\n* Have HbA1C \\\u003C6.0%.\n\nExclusion Criteria:\n\n* Rash, skin disease, or disorders of pigmentation (e.g., psoriasis, eczema, vitiligo, or other skin inflammatory skin disorders)\n* Known skin allergies to latex or adhesives\n* Smoking and\u002For use of nicotine-containing products within the past year\n* Use of illegal\u002Frecreational drugs\n* Generalized kidney disease\n* Taking chloramphenicol, cholestyramine, medication for seizures, methotrexate, nitrofurantoin, tetracycline, barbiturates, steroids, phenobarbital\u002Fphenytoin, orlistat or pyrimethamine\n* Any current medications which could conceivably alter the cardiovascular control or responses\n* Diagnosed or suspected metabolic or cardiovascular disease\n* Current pregnancy or breastfeeding\n* History of skin or other cancers\n* Diagnosed or suspected diabetes (HbA1c ≥6.0)\n* Anybody with narcolepsy or who has been diagnosed with any condition that impairs body temperature regulation.",true,"ALL","18 Years","75 Years",{"count":90,"type":91},60,"ESTIMATED","INTERVENTIONAL",[94],"PHASE2","Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and the non-Hispanic Black (NHB) population is disproportionately affected. Our research has previously demonstrated that oxidative stress may contribute to reduced vascular function in otherwise healthy NHB adults, potentially predisposing them to the development of hypertension and CVD. This study is designed to examine whether the mitochondria are an important source of oxidative stress-induced vascular dysfunction in healthy NHB adults.",[97],"Healthy",[99,100,101,102,103],"Vascular dysfunction","Cardiovascular disease","Hypertension","Nitric oxide","Endothelial function","2024-12-04",{"date":106,"type":107},"2024-12-09","ACTUAL",{"date":109,"type":107},"2024-07-01",{"date":111,"type":91},"2030-03-31",{"name":5,"class":6},1]