[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100567513":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":11,"centralContacts":37,"locations":43,"responsibleParty":59,"collaborators":11,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":11,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":11,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":11,"overallStatus":80,"whyStopped":11,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Tasly Pharmaceutical Group Co., Ltd","INDUSTRY",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo group","PLACEBO_COMPARATOR",null,[13],"Drug: Jia Shen Tablet Placebo",{"label":15,"type":16,"description":11,"interventionNames":17},"Low dose group","EXPERIMENTAL",[18],"Drug: Low dose Jia Shen Tablet",{"label":20,"type":16,"description":11,"interventionNames":21},"High dose group",[22],"Drug: High dose Jia Shen Tablet",[24,29,33],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"DRUG","Jia Shen Tablet Placebo","Jia Shen Tablet Placebo contains 4 placebo tablets (0.47 g per placebo tablet),take orally, 2 times a day for 12 weeks",[9],{"type":25,"name":30,"description":31,"armGroupLabels":32,"otherNames":11},"Low dose Jia Shen Tablet","Low dose Jia Shen Tablet contains 2 tablets (0.47 g per tablet) and 2 placebo tablets (0.47 g per placebo tablet),take orally, 2 times a day for 12 weeks",[15],{"type":25,"name":34,"description":35,"armGroupLabels":36,"otherNames":11},"High dose Jia Shen Tablet","High dose Jia Shen Tablet contains 4 tablets (0.47 g per tablet),take orally, 2 times a day for 12 weeks",[20],[38],{"name":39,"role":40,"phone":41,"phoneExt":11,"email":42},"Rui Liu","CONTACT","022-86343626","liurui2@tasly.com",[44],{"facility":45,"status":11,"city":46,"state":47,"zip":11,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"The First Affiliated Hospital of Tianjin University of traditional Chinese","Tianjin","Tianjin Municipality","China","CN",{"type":51,"coordinates":52},"Point",[53,54],117.17667,39.14222,{"lat":54,"lon":53},[57],{"name":58,"role":40,"phone":11,"phoneExt":11,"email":11},"Jingyuan Mao",{"type":60,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100567513","phase-2-efficacy-and-safety-of-jia-shen-tablets-in-chronic-heart-failure-100567513",false,"NCT06669169","Efficacy and Safety of Jia Shen Tablets in Chronic Heart Failure","A Randomized, Placebo-Controlled, Double-Blind and Multi-Centre Phase II Clinical Trial：Efficacy and Safety of Jia Shen Tablets in the Treatment of Coronary Heart Disease Complicating Chronic Heart Failure (Syndrome of Yang Qi Deficiency With Blood Stasis)","Inclusion Criteria:\n\n* Age 40-79 years, either sex;\n* Meet the diagnostic criteria for CHD and CHF;\n* Meet the TCM differentiation criteria of yang qi deficiency and blood stasis in CHF;\n* Class Ⅱ to Ⅲ for NYHA functional classification;\n* Willing to provide written informed consent.\n\nExclusion Criteria:\n\n* CHF with acute exacerbation or intravenous drug therapy;\n* Received cardiac resynchronization therapy (CRT) or other heart failure devices;\n* Within 3 months before randomization, acute coronary syndrome（ACS）, stroke or transient ischemic attack（TIA） occurred or received cardiac revascularization (PCI, CABG);\n* Plan to undergo cardiac revascularization (PCI, CABG) or cardiac resynchronization therapy (CRT) during the trial period;\n* Severe arrhythmias \\[such as persistent atrial fibrillation, permanent atrial fibrillation, ventricular tachycardia, second-degree type II or higher sinus or atrioventricular block without pacemaker placement, QT interval (QTc) exceeding 480 ms after heart rate adjustment according to Fridericia's formula, or known history or symptoms of long QT syndrome\\];\n* Severe hypertension (systolic blood pressure ≥180mm Hg or diastolic blood pressure ≥110mm Hg) or hypotension (systolic blood pressure \\\u003C 90 mmHg);\n* Heart failure caused by other cardiovascular diseases such as congenital heart disease, severe stenosis or insufficiency of heart valves, cardiomyopathy (e.g. hypertrophic obstructive cardiomyopathy, restrictive cardiomyopathy, dilated cardiomyopathy, alcoholic cardiomyopathy), moderate pericardial effusion, constrictive pericarditis, and infective endocarditis;\n* Combined with liver, kidney, hematopoietic system and other serious primary diseases, alanine aminotransferase (ALT) or aspartate aminotransferase (AST) more than 3 times the upper limit of local laboratory normal value, the estimated glomerular filtration rate (eGFR) \\\u003C 30 ml\u002Fmin\u002F1.73m2, Blood potassium \\> 5.5 mmol\u002FL or hemoglobin (Hb) \\\u003C 90 g\u002FL; Malignant tumors, severe neuroendocrine system diseases and mental diseases;\n* Pregnant or lactating;\n* Participating in other interventional clinical studies within 1 month before screening;\n* Allergic constitution, or allergic to Chinese medicines of Jia Shen Tablets (such as Periploca sepium, salvia miltiorrhiza, etc.);\n* The investigator determines that the patient is unable to complete the study or comply with the requirements of the study.","ALL","40 Years","79 Years",{"count":72,"type":73},288,"ESTIMATED","INTERVENTIONAL",[76],"PHASE2","Evaluate the efficacy and safety of Jia Shen Tablets in patients with Chronic Heart Failure.",[79],"Heart Failure","NOT_YET_RECRUITING","2024-10-31",{"date":83,"type":84},"2024-11-01","ACTUAL",{"date":86,"type":73},"2025-01-31",{"date":88,"type":73},"2026-12-31",{"name":5,"class":6},1]