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CherkasyRegCouncil ( Site 2509)","Cherkassy","Cherkasy Oblast","18009","Ukraine","UA",{"type":43,"coordinates":1346},[1347,1348],32.05738,49.44452,{"lat":1348,"lon":1347},{"facility":1351,"status":67,"city":1352,"state":1353,"zip":1354,"country":1343,"countryCode":1344,"cosmosGeoPoint":1355,"geoPoint":1359,"contacts":31},"Communal non-profit enterprise \"Regional clinical hospital o-Hematology Department ( Site 2510)","Ivano-Frankivsk","Ivano-Frankivsk Oblast","76008",{"type":43,"coordinates":1356},[1357,1358],24.71248,48.92312,{"lat":1358,"lon":1357},{"facility":1361,"status":36,"city":1362,"state":1363,"zip":1364,"country":1343,"countryCode":1344,"cosmosGeoPoint":1365,"geoPoint":1369,"contacts":1370},"Instit. of Blood Transfusion Medicine of the National Academy ( Site 2506)","Lviv","Lviv 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Kingdom","UK",{"type":43,"coordinates":1393},[1394,1395],-2.59665,51.45523,{"lat":1395,"lon":1394},[1398],{"name":50,"role":29,"phone":1399,"phoneExt":31,"email":31},"01173426733",{"facility":1401,"status":36,"city":1402,"state":1403,"zip":1404,"country":1390,"countryCode":1391,"cosmosGeoPoint":1405,"geoPoint":1409,"contacts":1410},"Nottingham University Hospitals NHS Trust. City Hospital Campus ( Site 2601)","Nottingham","England","NG5 1PF",{"type":43,"coordinates":1406},[1407,1408],-1.15047,52.9536,{"lat":1408,"lon":1407},[1411],{"name":50,"role":29,"phone":1412,"phoneExt":31,"email":31},"+441159691169",{"facility":1414,"status":36,"city":1415,"state":1403,"zip":1416,"country":1390,"countryCode":1391,"cosmosGeoPoint":1417,"geoPoint":1421,"contacts":1422},"GenesisCare - Windsor ( Site 2608)","Windsor","SL4 3HD",{"type":43,"coordinates":1418},[1419,1420],-0.6,51.48333,{"lat":1420,"lon":1419},[1423],{"name":50,"role":29,"phone":1424,"phoneExt":31,"email":31},"+447989474250",{"facility":1426,"status":36,"city":1427,"state":1428,"zip":1429,"country":1390,"countryCode":1391,"cosmosGeoPoint":1430,"geoPoint":1434,"contacts":1435},"Sarah Cannon Research Institute UK ( Site 2612)","London","London, City of","W1G 6AD",{"type":43,"coordinates":1431},[1432,1433],-0.12574,51.50853,{"lat":1433,"lon":1432},[1436],{"name":50,"role":29,"phone":1437,"phoneExt":31,"email":31},"02032195234",{"facility":1439,"status":36,"city":1440,"state":1441,"zip":1442,"country":1390,"countryCode":1391,"cosmosGeoPoint":1443,"geoPoint":1447,"contacts":1448},"GenesisCare - Oxford ( Site 2607)","Oxford","Oxfordshire","OX4 6LB",{"type":43,"coordinates":1444},[1445,1446],-1.25596,51.75222,{"lat":1446,"lon":1445},[1449],{"name":50,"role":29,"phone":1424,"phoneExt":31,"email":31},{"facility":1451,"status":36,"city":1452,"state":1453,"zip":1454,"country":1390,"countryCode":1391,"cosmosGeoPoint":1455,"geoPoint":1459,"contacts":1460},"GenesisCare - Cambridge ( Site 2611)","Newmarket","Suffolk","CB8 7XN",{"type":43,"coordinates":1456},[1457,1458],0.40418,52.24467,{"lat":1458,"lon":1457},[1461],{"name":50,"role":29,"phone":1462,"phoneExt":31,"email":31},"01223 655145",{"facility":1464,"status":36,"city":1465,"state":1466,"zip":1467,"country":1390,"countryCode":1391,"cosmosGeoPoint":1468,"geoPoint":1472,"contacts":1473},"The Royal Marsden NHS Foundation Trust. ( Site 2606)","Sutton","Surrey","SM2 5PT",{"type":43,"coordinates":1469},[1470,1471],-0.2,51.35,{"lat":1471,"lon":1470},[1474],{"name":50,"role":29,"phone":1475,"phoneExt":31,"email":31},"020 8642 6011",{"facility":1477,"status":36,"city":1478,"state":31,"zip":1479,"country":1390,"countryCode":1391,"cosmosGeoPoint":1480,"geoPoint":1484,"contacts":1485},"The Christie NHS Foundation Trust ( Site 2602)","Manchester","M20 4BX",{"type":43,"coordinates":1481},[1482,1483],-2.23743,53.48095,{"lat":1483,"lon":1482},[1486],{"name":50,"role":29,"phone":1487,"phoneExt":31,"email":31},"01619561217",{"type":1489,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR","100418452","phase-2-efficacy-and-safety-of-nemtabrutinib-mk-1026-in-participants-with-hematologic-malignancies-mk-1026-003-100418452",false,"NCT04728893","Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)","A Phase 2 Study to Evaluate the Efficacy and Safety of MK-1026 in Participants With Hematologic Malignancies","Inclusion Criteria:\n\n* Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2 within 7 days before C1D1 (the first dose of study treatment)\n* Has a life expectancy of at least 3 months, based on the investigator assessment\n* Has the ability to swallow and retain oral medication\n* Participants who are Hepatitis B surface antigen (HBsAg)-positive are eligible if they have received Hepatitis B virus (HBV) antiviral therapy for at least 4 weeks and have undetectable HBV viral load prior to randomization\n* Participants with history of Hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable at screening\n* Has adequate organ function\n* Male participants agree to refrain from donating sperm and agree to either remain abstinent from penile-vaginal intercourse as their preferred and usual lifestyle OR agree to use contraception, during the intervention period and for at least the time required to eliminate the study intervention after last dose of study intervention\n* Female participants assigned female sex at birth who are not pregnant or breastfeeding are eligible to participate if not a participant of childbearing potential (POCBP), or if a POCBP they either use a contraceptive method that is highly effective OR remain abstinent from penile-vaginal intercourse as their preferred and usual lifestyle during the intervention period and for at least to eliminate study intervention after the last dose of study intervention\n* Participants with Human immunodeficiency virus (HIV) are eligible if they meet all of the following: the CD4 count is \\>350 cells\u002FuL at screening, the HIV viral load is below the detectable level, are on a stable ART regimen for at least 4 weeks prior to study entry, and are compliant with their ART\n\nPart 1 and Part 2 (Cohorts A to C and J)\n\n* Has a confirmed diagnosis of Chronic lymphocytic leukemia\u002F Small lymphocytic lymphoma (CLL\u002FSLL) with\n\n  * At least 2 lines of prior therapy (Part 1 only)\n  * Part 2 Cohort A: CLL\u002FSLL participants who are relapsed or refractory to prior therapy with a covalent, irreversible Bruton's tyrosine kinase inhibitor (BTKi), and a B-cell lymphoma 2 inhibitor (BCL2i). CLL participants must have received and failed, been intolerant to, or determined by their treating physician to be a poor phosphoinositide 3-kinase inhibitor (PI3Ki) candidate or ineligible for a PI3Ki per local guidelines\n  * Part 2 Cohort B: CLL\u002FSLL participants who are relapsed or refractory following at least 1 line of prior therapy and are BTKi treatment naive\n  * Part 2 Cohort C: CLL\u002FSLL participants with 17p deletion or tumor protein p53 (TP53) mutation who are relapsed or refractory following at least 1 line of prior therapy\n  * Part 2 Cohort J: CLL\u002FSLL participants whose disease relapsed or was refractory to prior therapy with a covalent\u002Firreversible BTKi and BCL2i. NOTE: As of Protocol Amendment 09, at least 10 CLL\u002FSLL participants whose disease relapsed or was refractory to prior therapy with a covalent\u002Firreversible BTKi, BCL2i and noncovalent\u002Freversible BTKi (all three classes of therapies are required) will be enrolled into Cohort J\n  * Has active disease for CLL\u002FSLL clearly documented to initiate therapy\n  * For SLL participants in Part 2: Has evaluable core or excisional lymph node biopsy for biomarker analysis from an archival or newly obtained biopsy or bone marrow aspirate at Screening (optional for participants enrolling in Part 1)\n\nPart 2 (Cohorts D to G)\n\n\\- Has a confirmed diagnosis of and meets the following prior therapy requirements:\n\n* Participants with Richter's transformation who are relapsed or refractory following at least 1 line of prior therapy (Cohort D)\n* Participants with pathologically confirmed Mantle-cell lymphoma (MCL), documented by either overexpression of cyclin D1 or t (11;14), who are relapsed or are refractory to chemoimmunotherapy and a covalent irreversible BTKi (Cohort E)\n* Participants with Marginal zone lymphoma (MZL) (including splenic, nodal, and extra nodal MZL) who are relapsed or refractory to at least one prior line of systemic therapy including an anti-CD20-based regimen\n* Participants with Follicular lymphoma (FL) who are relapsed or refractory to chemoimmunotherapy and immunomodulatory agents (such as lenalidomide based regimen) (Cohort G)\n* Have measurable disease defined as at least 1 lesion that can be accurately measured in at least 2 dimensions with spiral Computed tomography (CT) scan\n* Has a lymph node biopsy for biomarker analysis from an archival or newly obtained biopsy or bone marrow aspirate (Cohort D) at Screening\n\nPart 2 (Cohort H): confirmed diagnosis of Waldenström's macroglobulinemia (WM); participants who are relapsed or refractory to standard therapies for WM including chemoimmunotherapy and a covalent irreversible BTKi\n\n* Has active disease defined as 1 of the following: systemic symptoms, physical findings, laboratory abnormalities, coexisting disease\n* Has measurable disease, satisfying any of the following: at least 1 lesion that can be accurately measured in at least 2 dimensions with spiral CT scan (minimum measurement must be \\>15 mm in the longest diameter or \\>10 mm in the short axis); IgM ≥450 mg\u002FdL; or bone marrow infiltration of 10%\n* Has fresh bone marrow aspirate or a lymph node biopsy for biomarker analysis at Screening or a lymph node biopsy from an archival\n\nExclusion Criteria:\n\n* Has active HBV\u002FHCV infection (Part 1 and Part 2)\n* Has a history of malignancy ≤3 years before providing documented informed consent. Participants with basal cell carcinoma of skin, squamous cell carcinoma of skin, or carcinoma in situ (e.g., breast carcinoma, cervical cancer in situ) that have undergone potential curative therapy are not excluded. Participants with low-risk, early-stage prostate cancer (T1-T2a, Gleason score ≤6, and prostate-specific antigen \\\u003C10 ng\u002FmL) either treated with definitive intent or untreated in active surveillance with SD are not excluded\n* Has active central nervous system (CNS) disease\n* Has an active infection requiring systemic therapy\n* Has received prior systemic anti-cancer therapy within 5 half-lives or 4 weeks (if prior therapy was a monoclonal antibody) before C1D1\n* Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study intervention\n* Has any clinically significant gastrointestinal abnormalities that might alter absorption\n* History of severe bleeding disorders","ALL","18 Years",{"count":1500,"type":1501},490,"ESTIMATED","INTERVENTIONAL",[1504],"PHASE2","The purpose of this study is to evaluate the safety and efficacy of nemtabrutinib (formerly ARQ 531) in participants with hematologic malignancies of chronic lymphocytic leukemia (CLL)\u002F small lymphocytic lymphoma (SLL), Richter's transformation, marginal zone lymphoma (MZL), mantle cell lymphoma (MCL), follicular lymphoma (FL), and Waldenström's macroglobulinemia (WM).",[1507,1508,1509,1510],"Hematologic Malignancies","Waldenstroms Macroglobulinaemia","Non-Hodgkins Lymphoma","Chronic Lymphocytic Leukaemia","2026-06-10",{"date":1513,"type":1514},"2026-06-12","ACTUAL",{"date":1516,"type":1514},"2021-04-05",{"date":1518,"type":1501},"2029-01-04",{"name":5,"class":6},121]