[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100572678":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":47,"centralContacts":57,"locations":28,"responsibleParty":63,"collaborators":28,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":28,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":28,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":28,"overallStatus":85,"whyStopped":28,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":28},{"fullName":5,"class":6},"Assiut University","OTHER",[8,17],{"label":9,"type":10,"description":11,"interventionNames":12},"group C","ACTIVE_COMPARATOR","(Group-C (control) (n=30); will have PENG block using 20ml of isobaric bupivacaine 0.25%",[13,14,15,16],"Procedure: Ultrasound guided Pericapsular Nerve Group Block","Drug: Isobaric Bupivacaine 0. 25%","Device: the ultrasound machine with curvilinear transducer (high -frequency probe, 2.5Mhz to 7.5Mhz)","Device: a standard echogenic 20-22 gauge 100mm needle",{"label":18,"type":10,"description":19,"interventionNames":20},"group D","Group-D (n=30); will have PENG block with 1.5μg\u002Fkg dexmedetomidine as an adjuvant to 20ml of isobaric bupivacaine 0.25%",[13,21,15,16],"Drug: 20 ml isobaric bupivacaine 0.25% and 1.5μg\u002Fkg dexmedetomidine",[23,29,34,38,43],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"PROCEDURE","Ultrasound guided Pericapsular Nerve Group Block","With the patient in the supine position and the leg slightly abducted, a curvilinear transducer (2.5-7.5 MHz) is prepared with sterile conduction gel and covered with a sterile probe cover. The transducer is placed transversely over the anterior superior iliac spine (ASIS), then aligned with the pubic ramus and rotated approximately 45° parallel to the inguinal crease. The probe is slid medially to identify key landmarks: the anterior inferior iliac spine (AIIS), iliopubic eminence (IPE), iliopsoas tendon, femoral artery, and femoral nerve. Sliding the probe distally or tilting caudally exposes the femoral head.\n\nA 20-22 gauge echogenic needle (100 mm) is inserted in-plane from lateral to medial, targeting the plane between the psoas tendon and the pubic ramus. the anesthetic agent is deposited to lift the psoas tendon while avoiding tendon puncture.",[9,18],null,{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":28},"DRUG","Isobaric Bupivacaine 0. 25%","group c will receive PENG block with only 20ml isobaric bupivacaine 0.25%",[9],{"type":30,"name":35,"description":36,"armGroupLabels":37,"otherNames":28},"20 ml isobaric bupivacaine 0.25% and 1.5μg\u002Fkg dexmedetomidine","group D will receive PENG block with 20 ml isobaric bupivacaine 0.25% and 1.5μg\u002Fkg dexmedetomidine",[18],{"type":39,"name":40,"description":41,"armGroupLabels":42,"otherNames":28},"DEVICE","the ultrasound machine with curvilinear transducer (high -frequency probe, 2.5Mhz to 7.5Mhz)","the two groups will receive the PENG block under ultrasound guidance",[9,18],{"type":39,"name":44,"description":45,"armGroupLabels":46,"otherNames":28},"a standard echogenic 20-22 gauge 100mm needle","the two groups will receive the PENG block using a standard echogenic 20-22 gauge 100mm needle",[9,18],[48,52,55],{"name":49,"affiliation":50,"role":51},"Mohamed Mohamed Abd Ellatif","Anesthesia, Intensive Care and Pain management ,Faculty of medicine, Assiut University","STUDY_DIRECTOR",{"name":53,"affiliation":54,"role":51},"Shereen Mamdooh Mohamed","Anesthesia, Intensive Care and Pain management South Egypt Cancer Institute, Assiut University",{"name":56,"affiliation":54,"role":51},"Moaaz Mohamed Tohamy",[58],{"name":59,"role":60,"phone":61,"phoneExt":28,"email":62},"Mahmoud Mamdooh Wardany","CONTACT","+201032899985","mahmoudwardany544@gmail.com",{"type":64,"investigatorFullName":59,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"PRINCIPAL_INVESTIGATOR","DOCTOR","100572678","phase-2-efficacy-of-dexmedetomidine-as-an-adjuvant-to-bupivacaine-in-pericapsular-nerve-group-block-in-hip-replacement-surgeries-100572678",false,"NCT06736392","Efficacy of Dexmedetomidine As an Adjuvant to Bupivacaine in Pericapsular Nerve Group Block in Hip Replacement Surgeries","Efficacy of Dexmedetomidine As an Adjuvant to Bupivacaine in Ultrasound Guided Pericapsular Nerve Group Block for Postoperative Analgesia During Spinal Anesthesia in Hip Replacement Surgeries, a Randomized Controlled Study","Inclusion Criteria:\n\n* Patients aged from 18 years to 90 years\n* Gender : both males and females\n* BMI less than 35 kg\u002Fm2\n* Patients with American society of anesthesiologists (ASA) classification class I , II or III\n* Patients scheduled for total or partial hip replacement surgery under spinal anesthesia\n\nExclusion Criteria:\n\n* Patient declining to give written informed consent\n* Patient with infection at the site of injection\n* Patient with coagulopathy\n* Patients with known allergy to used medications.\n* Psychiatric disorder","ALL","18 Years","90 Years",{"count":77,"type":78},60,"ESTIMATED","INTERVENTIONAL",[81],"PHASE2","Our aim will be to investigate the efficacy of dexmedetomidine as an adjuvant to bupivacaine in ultrasound guided pericapsular nerve group (PENG) block for postoperative analgesia in hip replacement surgeries.\n\n* Our primary outcome of the study: total amount of postoperative morphine consumption in the first 24h postoperative.\n* Our secondary outcome of the study: postoperative analgesia assessed by pain score (by Visual Analog Scale)",[84],"PENG Block","NOT_YET_RECRUITING","2024-12-13",{"date":88,"type":89},"2024-12-16","ACTUAL",{"date":91,"type":78},"2025-03-01",{"date":93,"type":78},"2027-03",{"name":5,"class":6}]