[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100564938":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":36,"centralContacts":41,"locations":46,"responsibleParty":65,"collaborators":23,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":23,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":23,"overallStatus":49,"whyStopped":23,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Institute of Hematology & Blood Diseases Hospital, China","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"venetoclax combined with intensive chemotherapy","EXPERIMENTAL","Induction therapy: daunorubicin, cytarabine, combined with venetoclax for 1 course.\n\nConsolidation therapy: cytarabine combined with venetoclax for 3 courses.\n\nMaintenance therapy: azacitidine combined with venetoclax for 6 courses.",[13,14,15,16],"Drug: Daunorubicin","Drug: Cytarabine","Drug: Venetoclax","Drug: Azacitidine",[18,24,28,32],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"DRUG","Daunorubicin","60mg\u002Fm2\u002Fd d1-3 in Induction therapy",[9],null,{"type":19,"name":25,"description":26,"armGroupLabels":27,"otherNames":23},"Cytarabine","Cytarabine 100mg\u002Fm2\u002Fd d1-7 in Induction therapy, 2g\u002Fm2 q12h d1-3 in Consolidation therapy",[9],{"type":19,"name":29,"description":30,"armGroupLabels":31,"otherNames":23},"Venetoclax","100mg d-2, 200mg d-1, 400mg d1-7 in Induction therapy, 400mg d1-7 in Consolidation therapy and Maintenance treatment",[9],{"type":19,"name":33,"description":34,"armGroupLabels":35,"otherNames":23},"Azacitidine","75mg\u002Fm2\u002Fd d1-5",[9],[37],{"name":38,"affiliation":39,"role":40},"Hui Wei, MD","Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","PRINCIPAL_INVESTIGATOR",[42],{"name":38,"role":43,"phone":44,"phoneExt":23,"email":45},"CONTACT","13132507161","weihui@ihcams.ac.cn",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Blood Diseases Hospital","RECRUITING","Tianjin","Tianjin Municipality","300020","China","CN",{"type":56,"coordinates":57},"Point",[58,59],117.17667,39.14222,{"lat":59,"lon":58},[62],{"name":63,"role":43,"phone":64,"phoneExt":23,"email":45},"hui wei, MD","86-13132507161",{"type":66,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100564938","phase-2-efficacy-of-venetoclax-combined-with-intensive-chemotherapy-in-different-subgroups-of-aml-100564938",false,"NCT06635681","Efficacy of Venetoclax Combined With Intensive Chemotherapy in Different Subgroups of AML","Efficacy of Venetoclax Combined With Intensive Chemotherapy in Different Subgroups of Acute Myeloid Leukemia : a Multi-center, Single-arm Clinical Trial","DAV-AML-2024","Inclusion Criteria:\n\n1. Patients who meet AML according to WHO (2022) or AML and MDS\u002FAML defined by ICC standards.\n2. Age ≥14 years old, ≤ 60 years old, male or female.\n3. The physical status assessment (ECOG-PS) of the Eastern Oncology Collaboration group was 0-2 points.\n4. Fulfill the requirements of the following laboratory tests (performed within 7 days prior to treatment) :\n\n   1. Total bilirubin ≤ 1.5 times the upper limit of normal value (same age);\n   2. AST and ALT≤ 2.5 times the upper limit of normal value (same age);\n   3. Blood creatinine \\\u003C 2 times the upper limit of normal (same age);\n   4. Myocardial enzymes \\\u003C 2 times the upper limit of normal (same age);\n   5. Left ventricular ejection fraction \\>50% by measure of echocardiogram (ECHO). Informed consent must be signed before the commencement of all specific study procedures, and signed by the patient himself or his immediate family. Considering the patient\\'s condition, if the patient\\'s signature is not conducive to the treatment of the condition, the informed consent shall be signed by the legal guardian or the patient\\'s immediate family.\n\nExclusion Criteria:\n\nSubjects who meet any of the following criteria are excluded from the study:\n\n1. Acute promyelocytic leukemia with PML-RARA fusion gene\n2. Acute myeloid leukemia with BCR-ABL fusion gene\n3. Treated patients (but can receive hydroxyurea or cytarabine to the lower tumor burden).\n4. Concurrent malignant tumors of other organs (those requiring treatment).\n5. Active heart disease, defined as one or more of the following:\n\n   1. A history of uncontrolled or symptomatic angina;\n   2. Myocardial infarction less than 6 months after enrollment;\n   3. Have a history of arrhythmia requiring drug treatment or severe clinical symptoms;\n   4. Uncontrolled or symptomatic congestive heart failure (\\> NYHA level 2);\n6. Serious infectious diseases (uncured tuberculosis, pulmonary aspergillosis).\n7. Those who were not considered suitable for inclusion by the researchers.","ALL","14 Years","60 Years",{"count":79,"type":80},380,"ESTIMATED","INTERVENTIONAL",[83],"PHASE2","Acute myeloid leukemia (AML) is a common hematological malignancy. Intensive chemotherapy is the main treatment in fit patients.\n\nRetrospective studies have shown that Venetoclax is highly effective in elder AML patients with IDH2 and NPM1 mutations while in those with TP53 and FLT3 mutations, the combination of azacitidine with Venetoclax showed an increased remission rate without improved survival.\n\nSince AML is a highly heterogeneous disease, it is not clear which genetic type of adult AML patients would benefit from Venetoclax combined with intensive chemotherapy.\n\nTherefore, this study intends to conduct a phase II clinical trial to investigate the efficacy of intensive chemotherapy combined with Venetoclax in adult AML patients, and reveal the efficacy of Venetoclax added to chemotherapy regimens for AML with different cytogenetic and molecular subgroups.",[86],"AML (Acute Myelogenous Leukemia)","2026-05-10",{"date":89,"type":90},"2026-05-13","ACTUAL",{"date":92,"type":90},"2024-09-29",{"date":94,"type":80},"2028-10-01",{"name":5,"class":6},1]