[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100519985":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":39,"responsibleParty":72,"collaborators":76,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":18,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":90,"maxAge":18,"enrollmentInfo":91,"targetDuration":18,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":18,"overallStatus":42,"whyStopped":18,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"University of Iowa","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Essential Amino Acid Supplementation","EXPERIMENTAL","Subjects randomized to intervention arm of this study will receive essential amino acid (EAA)-based oral nutrition supplementation in addition to standard of care postoperative nutrition. Subjects will take 1 scoop (26.7g) of supplement twice daily for 4 weeks after injury. Supplementation will begin within 72 hours of surgical fixation. The EAA-based supplement used in this clinical trial is MEND™ Repair and Recover®.",[13],"Combination Product: Essential Amino Acid Supplementation",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard of Care Postoperative Nutrition","NO_INTERVENTION","Subjects randomized to the control arm of this study will receive no intervention. They will receive standard of care postoperative nutrition.",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"COMBINATION_PRODUCT","Powdered supplement that can be mixed into beverage of choice. Ingredients: Zinc, Vitamin A, Vitamin C, Whey Protein, Leucine, Calcium, Vitamin D, Glutamine, Boron, Turmeric, Bioperine, Iron, β-hydroxy β-methylbutyrate (HMB)",[9],[25],"MEND Repair & Recover",[27],{"name":28,"affiliation":5,"role":29},"Michael C Willey, MD","PRINCIPAL_INVESTIGATOR",[31,35],{"name":28,"role":32,"phone":33,"phoneExt":18,"email":34},"CONTACT","319-384-8452","michael-willey@uiowa.edu",{"name":36,"role":32,"phone":37,"phoneExt":18,"email":38},"Ashley S Kochuyt, BS","319-929-3559","ashley-kochuyt@uiowa.edu",[40,56],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"University of Iowa Health Care","RECRUITING","Iowa City","Iowa","52242","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-91.53017,41.66113,{"lat":52,"lon":51},[55],{"name":36,"role":32,"phone":18,"phoneExt":18,"email":38},{"facility":57,"status":58,"city":59,"state":60,"zip":61,"country":46,"countryCode":47,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Slocum Center for Orthopedics & Sports Medicine","NOT_YET_RECRUITING","Eugene","Oregon","97401",{"type":49,"coordinates":63},[64,65],-123.08675,44.05207,{"lat":65,"lon":64},[68],{"name":69,"role":32,"phone":70,"phoneExt":18,"email":71},"Tessa Kirkpatrick","5418680658","tessa.kirkpatrick@slocumfoundation.org",{"type":73,"investigatorFullName":74,"investigatorTitle":75,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"SPONSOR_INVESTIGATOR","Michael C Willey","Assistant Professor",[77,80],{"name":78,"class":79},"MEND","UNKNOWN",{"name":81,"class":6},"Slocum Research & Education Foundation","100519985","phase-2-essential-amino-acid-supplementation-for-femoral-fragility-fractures-100519985",false,"NCT06050668","Essential Amino Acid Supplementation for Femoral Fragility Fractures","MEND Repair & Recover Clinical Trial","Inclusion Criteria:\n\n* Hospital inpatient\n* Age ≥ 65 years old on admission\n* Low-energy mechanism of injury\n* Diagnosis of femur fracture (OTA 31, 32, or 33 fracture)\n* Indicated for surgical fixation\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Part of a vulnerable population (ex: Incarcerated, Non-English speaking)\n* Cognitive impairment (MMSE score ≤ 17)\n* Electrical medical implant (ex: Pacemaker\u002FDefibrillator, Left Ventricular Assist Device, Cochlear implant, Insulin pump, Pain medication pumps, Spinal cord stimulator)\n* Non-ambulatory prior to injury\n* Inability to consume an oral diet or allergy to supplement ingredients (ex: milk allergy)\n* Concern for inability to complete follow-up\n* Hemi or total arthroplasty (joint replacement)\n* Patients with a historical diagnosis of chronic kidney disease (CKD)","ALL","65 Years",{"count":92,"type":93},60,"ESTIMATED","INTERVENTIONAL",[96],"PHASE2","This trial will evaluate the impact of 4 weeks of postoperative essential amino acid (EAA)-based supplementation on muscle morphology after femoral fragility fracture. This trial will assess the ability of EAA-based to increase skeletal muscle metabolic activity, reduce inflammation, and induce muscle fiber hypertrophy, as well as preserve skeletal muscle mass and physical performance up to 6 months after injury. Participants will be randomized in a 1:1 ratio to 1) standard of care (no dietary intervention) or 2) EAA-based supplementation.",[99,100,101],"Femoral Fracture","Fragility Fracture","Muscle Atrophy","2026-04-14",{"date":104,"type":105},"2026-04-15","ACTUAL",{"date":107,"type":105},"2024-06-17",{"date":109,"type":93},"2026-12",{"name":74,"class":6},2]