[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100412187":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":57,"collaborators":59,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":78,"sex":84,"minAge":85,"maxAge":25,"enrollmentInfo":86,"targetDuration":25,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"University College Dublin","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Home Blood Pressure Measurement, Telemonitoring and Medication titration","EXPERIMENTAL","Medication titration to guideline SBP \\\u003C130mmHg",[13],"Other: anti-hypertensive, home blood pressure measurement, telemonitoring and medication titration",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group: Standard of Care Blood Pressure Management","ACTIVE_COMPARATOR","Standard of Care Management by GP\u002Fphysician to SBP \\\u003C130mmHg by current European Stroke Organisation, American Stroke Association and UK NICE guidelines",[19],"Other: Standard of Care Blood Pressure Management with Antihypertensives",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"anti-hypertensive, home blood pressure measurement, telemonitoring and medication titration","A medication algorithm based on the SPRINT trial protocol will be provided for patients in the home blood pressure measurement arm. The final choice and dose of antihypertensive treatment(s) will be at the discretion of the treating clinicians. If no contra-indications, indapamide or other thiazide diuretic and\u002For angiotensin-converting enzyme (ACE) inhibitor (perindopril or other) will be encouraged as initial therapy, with long-acting calcium-channel antagonists (eg.amlodipine) encouraged as third-line therapy.\n\nPatients will have their home blood pressure monitoring diary reviewed by the study team. If SBP is out of the allocated target range, a prescription to titrate antihypertensive medication will be sent to the patient at least monthly.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Standard of Care Blood Pressure Management with Antihypertensives","Participants in the standard of care arm will receive antihypertensive therapy at the physician's discretion to the same treatment target of SBP \\\u003C130mmHg.",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Katrina Tobin","CONTACT","+353 1 716 4576","katrina.tobin@ucd.ie",[37],{"facility":38,"status":39,"city":40,"state":25,"zip":25,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Mater Misericordiae University Hospital","RECRUITING","Dublin","Ireland","IE",{"type":44,"coordinates":45},"Point",[46,47],-6.24889,53.33306,{"lat":47,"lon":46},[50,51,54],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},{"name":52,"role":53,"phone":25,"phoneExt":25,"email":25},"Peter Kelly","PRINCIPAL_INVESTIGATOR",{"name":55,"role":56,"phone":25,"phoneExt":25,"email":25},"Pádraig Synnott","SUB_INVESTIGATOR",{"type":58,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[60,62,64,66,69,71,72,74],{"name":61,"class":6},"St Vincent's University Hospital, Ireland",{"name":63,"class":6},"Cork University Hospital",{"name":65,"class":6},"Tallaght University Hospital",{"name":67,"class":68},"HRB Stroke Trials Network Ireland","UNKNOWN",{"name":70,"class":6},"National University of Ireland, Galway, Ireland",{"name":38,"class":6},{"name":73,"class":6},"St. James's Hospital, Ireland",{"name":75,"class":6},"Connolly Hospital Blanchardstown","100412187","phase-2-european-blood-pressure-intensive-control-after-stroke-100412187",false,"NCT04647292","European Blood Pressure Intensive Control After Stroke","European Blood Pressure Intensive Control After Stroke - Pilot Trial","EPICS-Pilot","Inclusion Criteria:\n\n1. Age ≥40\n2. Ischaemic stroke1, high-risk TIA, proven by imaging (brain CT\u002FMRI)\n3. Living at home and independent (walking without the aid of another person, but may have some help for daily activities)\n4. SBP≥140mmHg at entry (average of 2 measures, seated, in the same arm, after resting alone in office for 10 minutes)\n5. Qualifying event between 30 days and 1 year of randomisation\n6. Glomerular filtration rate (eGFR) greater than or equal to 50ml\u002Fmin\u002Fm2 (within 3 months of randomisation)\n7. Medically-stable and capable of participating in a randomised trial, including home BP measures, in the opinion of the study physician\n8. Willing to provide informed consent (no surrogate consent will apply)\n\nExclusion Criteria:\n\n1. SBP \\\u003C110mmHg after 3 minutes of standing or other contra-indication to intensive SBP lowering in opinion of treating clinician (eg. Orthostatic symptoms, syncope or pre syncope, recurrent falls)\n2. Qualifying stroke due to intracerebral haemorrhage (ICH), cardio-embolism or other defined causes (eg. dissection, endocarditis, other specified)\n3. Severe stenosis or occlusion of large cranio-cervical artery (\\>70% stenosis\u002Focclusion of cervical carotid, vertebral, or Circle of Willis artery)\n4. Unlikely to comply with study procedures due to severe or fatal comorbid illness (eg. dementia, active malignancy, severe frailty) or other factor (eg. inability to travel)\n5. Pregnancy or breastfeeding","ALL","40 Years",{"count":87,"type":88},142,"ESTIMATED","INTERVENTIONAL",[91],"PHASE2","Stroke is the third most common cause of death worldwide and the leading cause of disability. High blood pressure is an important risk factor for stroke. Lowering a person's blood pressure reduces the risk of future stroke or heart attack, and current guidelines recommend treatment to a target of \\\u003C130mmHg for secondary prevention.\n\nHome blood pressure measurement and telemonitoring are acceptable to patients, but there is uncertainty over the use of out of office blood pressure measurements in stroke patients in guidelines.\n\nThis is a study designed to establish the feasibility of a larger clinical trial, comparing home blood pressure monitoring, telemonitoring and medication titration with standard care. The study hypothesis is that home BP measurement and telemonitoring with medication titration may lead to improved BP control compared to standard of care clinical practice.",[94,95],"Ischemic Stroke","Transient Ischemic Attack",[97,98,99,100,101,102,103,104,105,106],"ischemic stroke","transient ischemic attack","blood pressure","hypertension","recurrence","prognosis","prevention","randomized control trial","myocardial infarction","vascular events","2024-07-09",{"date":109,"type":110},"2024-07-11","ACTUAL",{"date":112,"type":110},"2024-05-02",{"date":114,"type":88},"2026-03",{"name":5,"class":6},1]