[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100492173":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":11,"centralContacts":37,"locations":43,"responsibleParty":548,"collaborators":11,"id":550,"slug":551,"hasResults":552,"nctId":553,"briefTitle":554,"officialTitle":555,"acronym":11,"eligibilityCriteria":556,"healthyVolunteers":552,"sex":557,"minAge":558,"maxAge":559,"enrollmentInfo":560,"targetDuration":11,"studyType":563,"phases":564,"briefSummary":566,"conditions":567,"keywords":11,"overallStatus":46,"whyStopped":11,"lastUpdateSubmitDate":569,"lastUpdatePostDateStruct":570,"startDateStruct":573,"completionDateStruct":575,"leadSponsor":577,"locationsCount":578},{"fullName":5,"class":6},"Beijing InnoCare Pharma Tech Co., Ltd.","INDUSTRY",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Orelabrutinib Lower Dose","EXPERIMENTAL",null,[13],"Drug: Orelabrutinib (Low Dose)",{"label":15,"type":10,"description":11,"interventionNames":16},"Orelabrutinib Higher Dose",[17],"Drug: Orelabrutinib (High Dose)",{"label":19,"type":20,"description":11,"interventionNames":21},"Placebo","PLACEBO_COMPARATOR",[22],"Drug: Orelabrutinib Placebo",[24,29,33],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"DRUG","Orelabrutinib (Low Dose)","Subjects will be administered with lower dose of Orelabrutinib orally once daily in combination with SOC therapy",[9],{"type":25,"name":30,"description":31,"armGroupLabels":32,"otherNames":11},"Orelabrutinib (High Dose)","Subjects will be administered with higher dose of Orelabrutinib orally once daily in combination with SOC therapy",[15],{"type":25,"name":34,"description":35,"armGroupLabels":36,"otherNames":11},"Orelabrutinib Placebo","Subjects will be administered with Orelabrutinib Placebo orally once daily in combination with SOC therapy",[19],[38],{"name":39,"role":40,"phone":41,"phoneExt":11,"email":42},"Zhanguo Li, PhD","CONTACT","010-88324172","Zgli@yahoo.cn",[44,61,73,86,96,105,118,131,143,155,168,181,193,206,218,231,243,256,269,281,293,306,318,331,343,356,369,382,395,407,419,432,440,453,461,473,486,499,512,524,536],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"The first affiliated hospital of bengbu medical college","RECRUITING","Bengbu","Anhui","233099","China","CN",{"type":53,"coordinates":54},"Point",[55,56],117.36083,32.94083,{"lat":56,"lon":55},[59],{"name":60,"role":40,"phone":11,"phoneExt":11,"email":11},"Changhao Xie",{"facility":62,"status":46,"city":63,"state":48,"zip":64,"country":50,"countryCode":51,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"The First Affiliated Hospital of Anhui Medical University","Hefei","230022",{"type":53,"coordinates":66},[67,68],117.28083,31.86389,{"lat":68,"lon":67},[71],{"name":72,"role":40,"phone":11,"phoneExt":11,"email":11},"Zongwen Shuai",{"facility":74,"status":46,"city":75,"state":76,"zip":77,"country":50,"countryCode":51,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"Peking University People's Hospital","Beijing","Beijing Municipality","100000",{"type":53,"coordinates":79},[80,81],116.39723,39.9075,{"lat":81,"lon":80},[84],{"name":85,"role":40,"phone":11,"phoneExt":11,"email":11},"Zhanguo Li",{"facility":87,"status":88,"city":75,"state":76,"zip":89,"country":50,"countryCode":51,"cosmosGeoPoint":90,"geoPoint":92,"contacts":93},"China-Japan Friendship Hospital","NOT_YET_RECRUITING","100029",{"type":53,"coordinates":91},[80,81],{"lat":81,"lon":80},[94],{"name":95,"role":40,"phone":11,"phoneExt":11,"email":11},"GuoChun Wang",{"facility":97,"status":46,"city":75,"state":76,"zip":98,"country":50,"countryCode":51,"cosmosGeoPoint":99,"geoPoint":101,"contacts":102},"Beijing Friendship Hospital, Capital Medical University","100050",{"type":53,"coordinates":100},[80,81],{"lat":81,"lon":80},[103],{"name":104,"role":40,"phone":11,"phoneExt":11,"email":11},"Yanying Liu",{"facility":106,"status":46,"city":107,"state":108,"zip":109,"country":50,"countryCode":51,"cosmosGeoPoint":110,"geoPoint":114,"contacts":115},"The First Affiliated Hospital of XiaMen University","Xiamen","Fujian","361009",{"type":53,"coordinates":111},[112,113],118.08187,24.47979,{"lat":113,"lon":112},[116],{"name":117,"role":40,"phone":11,"phoneExt":11,"email":11},"Guixiu Shi",{"facility":119,"status":46,"city":120,"state":121,"zip":122,"country":50,"countryCode":51,"cosmosGeoPoint":123,"geoPoint":127,"contacts":128},"The First Affiliated Hospital,Sun Yat-sen University","Guangzhou","Guangdong","510080",{"type":53,"coordinates":124},[125,126],113.25,23.11667,{"lat":126,"lon":125},[129],{"name":130,"role":40,"phone":11,"phoneExt":11,"email":11},"Niansheng Yang",{"facility":132,"status":46,"city":133,"state":121,"zip":134,"country":50,"countryCode":51,"cosmosGeoPoint":135,"geoPoint":139,"contacts":140},"The first affiliated hospital of shantou university medical college","Shantou","515041",{"type":53,"coordinates":136},[137,138],116.67876,23.35489,{"lat":138,"lon":137},[141],{"name":142,"role":40,"phone":11,"phoneExt":11,"email":11},"Zhiduo Hou",{"facility":144,"status":46,"city":145,"state":121,"zip":146,"country":50,"countryCode":51,"cosmosGeoPoint":147,"geoPoint":151,"contacts":152},"The Seventh Affiliated Hospital, Sun Yat-sen University","Shenzhen","518107",{"type":53,"coordinates":148},[149,150],114.0683,22.54554,{"lat":150,"lon":149},[153],{"name":154,"role":40,"phone":11,"phoneExt":11,"email":11},"Ruojie Gu",{"facility":156,"status":46,"city":157,"state":158,"zip":159,"country":50,"countryCode":51,"cosmosGeoPoint":160,"geoPoint":164,"contacts":165},"Affiliated Hospital of Guilin Medical University","Guilin","Guangxi","541001",{"type":53,"coordinates":161},[162,163],110.29639,25.28022,{"lat":163,"lon":162},[166],{"name":167,"role":40,"phone":11,"phoneExt":11,"email":11},"Baozhen Li",{"facility":169,"status":46,"city":170,"state":171,"zip":172,"country":50,"countryCode":51,"cosmosGeoPoint":173,"geoPoint":177,"contacts":178},"Affiliated Hospital of HeBei University","Baoding","Hebei","071030",{"type":53,"coordinates":174},[175,176],115.46246,38.87288,{"lat":176,"lon":175},[179],{"name":180,"role":40,"phone":11,"phoneExt":11,"email":11},"Minghua Xu",{"facility":182,"status":46,"city":183,"state":171,"zip":184,"country":50,"countryCode":51,"cosmosGeoPoint":185,"geoPoint":189,"contacts":190},"Hebei People's Hospital","Shijiazhuang","050051",{"type":53,"coordinates":186},[187,188],114.47861,38.04139,{"lat":188,"lon":187},[191],{"name":192,"role":40,"phone":11,"phoneExt":11,"email":11},"Fang Li",{"facility":194,"status":46,"city":195,"state":196,"zip":197,"country":50,"countryCode":51,"cosmosGeoPoint":198,"geoPoint":202,"contacts":203},"Daqing Oilfield General Hospital","Daqing","Heilongjiang","Contact: Junsong Li",{"type":53,"coordinates":199},[200,201],125,46.58333,{"lat":201,"lon":200},[204],{"name":205,"role":40,"phone":11,"phoneExt":11,"email":11},"Junsong Li",{"facility":207,"status":46,"city":208,"state":196,"zip":209,"country":50,"countryCode":51,"cosmosGeoPoint":210,"geoPoint":214,"contacts":215},"The first hospital of Qiqihar","Qiqihar","161005",{"type":53,"coordinates":211},[212,213],123.96154,47.33922,{"lat":213,"lon":212},[216],{"name":217,"role":40,"phone":11,"phoneExt":11,"email":11},"Wei Zhong",{"facility":219,"status":46,"city":220,"state":221,"zip":222,"country":50,"countryCode":51,"cosmosGeoPoint":223,"geoPoint":227,"contacts":228},"The First Affiliated Hospital of Henan University of Science and Technology","Luoyang","Henan","471003",{"type":53,"coordinates":224},[225,226],112.43684,34.67345,{"lat":226,"lon":225},[229],{"name":230,"role":40,"phone":11,"phoneExt":11,"email":11},"Xiaofei Shi",{"facility":232,"status":46,"city":233,"state":221,"zip":234,"country":50,"countryCode":51,"cosmosGeoPoint":235,"geoPoint":239,"contacts":240},"First Affiliated Hospital of Zhengzhou University","Zhengzhou","450052",{"type":53,"coordinates":236},[237,238],113.64861,34.75778,{"lat":238,"lon":237},[241],{"name":242,"role":40,"phone":11,"phoneExt":11,"email":11},"Shengyun Liu",{"facility":244,"status":46,"city":245,"state":246,"zip":247,"country":50,"countryCode":51,"cosmosGeoPoint":248,"geoPoint":252,"contacts":253},"Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology","Wuhan","Hubei","430022",{"type":53,"coordinates":249},[250,251],114.26667,30.58333,{"lat":251,"lon":250},[254],{"name":255,"role":40,"phone":11,"phoneExt":11,"email":11},"Anbin Huang",{"facility":257,"status":88,"city":258,"state":259,"zip":260,"country":50,"countryCode":51,"cosmosGeoPoint":261,"geoPoint":265,"contacts":266},"The Second XIANGYA Hospital Of Central South University","Changsha","Hunan","410000",{"type":53,"coordinates":262},[263,264],112.97087,28.19874,{"lat":264,"lon":263},[267],{"name":268,"role":40,"phone":11,"phoneExt":11,"email":11},"Jing Tian",{"facility":270,"status":46,"city":271,"state":259,"zip":272,"country":50,"countryCode":51,"cosmosGeoPoint":273,"geoPoint":277,"contacts":278},"Yiyang Central Hospital","Yiyang","413000",{"type":53,"coordinates":274},[275,276],112.37925,26.38893,{"lat":276,"lon":275},[279],{"name":280,"role":40,"phone":11,"phoneExt":11,"email":11},"Jian Shi",{"facility":282,"status":46,"city":283,"state":259,"zip":284,"country":50,"countryCode":51,"cosmosGeoPoint":285,"geoPoint":289,"contacts":290},"Zhuzhou Central Hospital","Zhuzhou","412000",{"type":53,"coordinates":286},[287,288],113.15,27.83333,{"lat":288,"lon":287},[291],{"name":292,"role":40,"phone":11,"phoneExt":11,"email":11},"Zhenhua Wen",{"facility":294,"status":46,"city":295,"state":296,"zip":297,"country":50,"countryCode":51,"cosmosGeoPoint":298,"geoPoint":302,"contacts":303},"The Second Affiliated Hospital of Soochow University","Suzhou","Jiangsu","215004",{"type":53,"coordinates":299},[300,301],120.59538,31.30408,{"lat":301,"lon":300},[304],{"name":305,"role":40,"phone":11,"phoneExt":11,"email":11},"Zhichun Liu",{"facility":307,"status":46,"city":308,"state":296,"zip":309,"country":50,"countryCode":51,"cosmosGeoPoint":310,"geoPoint":314,"contacts":315},"Xuzhou Central Hospital","Xuzhou","221000",{"type":53,"coordinates":311},[312,313],117.28386,34.20442,{"lat":313,"lon":312},[316],{"name":317,"role":40,"phone":11,"phoneExt":11,"email":11},"Lin Liu",{"facility":319,"status":46,"city":320,"state":321,"zip":322,"country":50,"countryCode":51,"cosmosGeoPoint":323,"geoPoint":327,"contacts":328},"Jiujiang NO.1 People's Hospital","Jiujiang","Jiangxi","332000",{"type":53,"coordinates":324},[325,326],116.00206,29.70475,{"lat":326,"lon":325},[329],{"name":330,"role":40,"phone":11,"phoneExt":11,"email":11},"Ju Liu",{"facility":332,"status":46,"city":333,"state":321,"zip":334,"country":50,"countryCode":51,"cosmosGeoPoint":335,"geoPoint":339,"contacts":340},"The First Affiliated Hospital of Nanchang University","Nanchang","330006",{"type":53,"coordinates":336},[337,338],115.85306,28.68396,{"lat":338,"lon":337},[341],{"name":342,"role":40,"phone":11,"phoneExt":11,"email":11},"Rui Wu",{"facility":344,"status":46,"city":345,"state":346,"zip":347,"country":50,"countryCode":51,"cosmosGeoPoint":348,"geoPoint":352,"contacts":353},"Jilin Provincial People's Hospital","Changchun","Jilin","130021",{"type":53,"coordinates":349},[350,351],125.32278,43.88,{"lat":351,"lon":350},[354],{"name":355,"role":40,"phone":11,"phoneExt":11,"email":11},"Guoping Jiang",{"facility":357,"status":46,"city":358,"state":359,"zip":360,"country":50,"countryCode":51,"cosmosGeoPoint":361,"geoPoint":365,"contacts":366},"Shengjing Hospital of china medical university","Shenyang","Liaoning","110004",{"type":53,"coordinates":362},[363,364],123.43278,41.79222,{"lat":364,"lon":363},[367],{"name":368,"role":40,"phone":11,"phoneExt":11,"email":11},"Xiaofei Wang",{"facility":370,"status":88,"city":371,"state":372,"zip":373,"country":50,"countryCode":51,"cosmosGeoPoint":374,"geoPoint":378,"contacts":379},"Affiliated Hospital of Inner Mongolia Medical University","Hohhot","Nei Monggol Autonomous Region","010000",{"type":53,"coordinates":375},[376,377],111.65222,40.81056,{"lat":377,"lon":376},[380],{"name":381,"role":40,"phone":11,"phoneExt":11,"email":11},"Hongbin Li",{"facility":383,"status":46,"city":384,"state":385,"zip":386,"country":50,"countryCode":51,"cosmosGeoPoint":387,"geoPoint":391,"contacts":392},"Affiliated Hospital of Binzhou Medical College","Binzhou","Shandong","256699",{"type":53,"coordinates":388},[389,390],118.01667,37.36667,{"lat":390,"lon":389},[393],{"name":394,"role":40,"phone":11,"phoneExt":11,"email":11},"Xuebin Wang",{"facility":396,"status":46,"city":397,"state":385,"zip":398,"country":50,"countryCode":51,"cosmosGeoPoint":399,"geoPoint":403,"contacts":404},"Jining First People's Hospital","Jining","272002",{"type":53,"coordinates":400},[401,402],116.58139,35.405,{"lat":402,"lon":401},[405],{"name":406,"role":40,"phone":11,"phoneExt":11,"email":11},"Jianhong Zhao",{"facility":408,"status":46,"city":409,"state":385,"zip":410,"country":50,"countryCode":51,"cosmosGeoPoint":411,"geoPoint":415,"contacts":416},"Linyi People's Hospital","Linyi","276034",{"type":53,"coordinates":412},[413,414],118.34278,35.06306,{"lat":414,"lon":413},[417],{"name":418,"role":40,"phone":11,"phoneExt":11,"email":11},"Zunzhong Li",{"facility":420,"status":46,"city":421,"state":422,"zip":423,"country":50,"countryCode":51,"cosmosGeoPoint":424,"geoPoint":428,"contacts":429},"Changhai Hospital of Shanghai","Shanghai","Shanghai Municipality","200000",{"type":53,"coordinates":425},[426,427],121.45806,31.22222,{"lat":427,"lon":426},[430],{"name":431,"role":40,"phone":11,"phoneExt":11,"email":11},"Jie Gao",{"facility":433,"status":46,"city":421,"state":422,"zip":423,"country":50,"countryCode":51,"cosmosGeoPoint":434,"geoPoint":436,"contacts":437},"Renji Hospital, Shanghai Jiao Tong University School of Medicine",{"type":53,"coordinates":435},[426,427],{"lat":427,"lon":426},[438],{"name":439,"role":40,"phone":11,"phoneExt":11,"email":11},"Sheng Chen",{"facility":441,"status":46,"city":442,"state":443,"zip":444,"country":50,"countryCode":51,"cosmosGeoPoint":445,"geoPoint":449,"contacts":450},"The First Hospital of Shanxi Medical University","Taiyuan","Shanxi","030001",{"type":53,"coordinates":446},[447,448],112.56028,37.86944,{"lat":448,"lon":447},[451],{"name":452,"role":40,"phone":11,"phoneExt":11,"email":11},"Zili Fu",{"facility":454,"status":46,"city":442,"state":443,"zip":444,"country":50,"countryCode":51,"cosmosGeoPoint":455,"geoPoint":457,"contacts":458},"The Second Hospital of Shanxi Medical University",{"type":53,"coordinates":456},[447,448],{"lat":448,"lon":447},[459],{"name":460,"role":40,"phone":11,"phoneExt":11,"email":11},"Xiaoxia Wang",{"facility":462,"status":46,"city":463,"state":443,"zip":464,"country":50,"countryCode":51,"cosmosGeoPoint":465,"geoPoint":469,"contacts":470},"The First Affiliated Hospital of Xi 'an Jiaotong University","Xi’an","710061",{"type":53,"coordinates":466},[467,468],113.52486,35.99785,{"lat":468,"lon":467},[471],{"name":472,"role":40,"phone":11,"phoneExt":11,"email":11},"Lan He",{"facility":474,"status":88,"city":475,"state":476,"zip":477,"country":50,"countryCode":51,"cosmosGeoPoint":478,"geoPoint":482,"contacts":483},"Tianjin Medical University General Hospital","Tianjin","Tianjin Municipality","300000",{"type":53,"coordinates":479},[480,481],117.17667,39.14222,{"lat":481,"lon":480},[484],{"name":485,"role":40,"phone":11,"phoneExt":11,"email":11},"Wei Wei",{"facility":487,"status":46,"city":488,"state":489,"zip":490,"country":50,"countryCode":51,"cosmosGeoPoint":491,"geoPoint":495,"contacts":496},"Xinjiang Uygur Autonomous Region People's Hospital","Ürümqi","Xinjiang","830000",{"type":53,"coordinates":492},[493,494],87.60046,43.80096,{"lat":494,"lon":493},[497],{"name":498,"role":40,"phone":11,"phoneExt":11,"email":11},"Lijun Wu",{"facility":500,"status":46,"city":501,"state":502,"zip":503,"country":50,"countryCode":51,"cosmosGeoPoint":504,"geoPoint":508,"contacts":509},"The Third People's Hospital of Huzhou","Huzhou","Zhejiang","313002",{"type":53,"coordinates":505},[506,507],120.0933,30.8703,{"lat":507,"lon":506},[510],{"name":511,"role":40,"phone":11,"phoneExt":11,"email":11},"Xiaobing Yang",{"facility":513,"status":46,"city":514,"state":502,"zip":515,"country":50,"countryCode":51,"cosmosGeoPoint":516,"geoPoint":520,"contacts":521},"The First Hospital of Ningbo","Ningbo","315010",{"type":53,"coordinates":517},[518,519],121.54945,29.87819,{"lat":519,"lon":518},[522],{"name":523,"role":40,"phone":11,"phoneExt":11,"email":11},"Wen Qin",{"facility":525,"status":46,"city":526,"state":502,"zip":527,"country":50,"countryCode":51,"cosmosGeoPoint":528,"geoPoint":532,"contacts":533},"The First People's Hospital of Wenling","Wenling","317500",{"type":53,"coordinates":529},[530,531],121.38416,28.37524,{"lat":531,"lon":530},[534],{"name":535,"role":40,"phone":11,"phoneExt":11,"email":11},"Yongjun Cheng",{"facility":537,"status":46,"city":538,"state":502,"zip":539,"country":50,"countryCode":51,"cosmosGeoPoint":540,"geoPoint":544,"contacts":545},"Wenzhou People's Hospital","Wenzhou","325099",{"type":53,"coordinates":541},[542,543],120.66682,27.99942,{"lat":543,"lon":542},[546],{"name":547,"role":40,"phone":11,"phoneExt":11,"email":11},"Suxian Lin",{"type":549,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100492173","phase-2-evaluate-the-efficacy-and-safety-of-orelabrutinib-in-adult-patients-with-systemic-lupus-erythematosus-100492173",false,"NCT05688696","Evaluate the Efficacy and Safety of Orelabrutinib in Adult Patients With Systemic Lupus Erythematosus","A Phase IIb, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Orelabrutinib in Adult Patients With Systemic Lupus Erythematosus","Inclusion Criteria:\n\n1. have had a detailed understanding of the nature, significance, potential benefits, potential risks, and procedures of the study, and voluntarily signed a written Informed Consent Form (ICF).\n2. Males or females aged≥18 and ≤75 years.\n3. Have a clinical diagnosis of SLE 6 months prior to signing the ICF, meeting at least 4 of the 11 American College of Rheumatology (ACR) classification criteria for SLE.\n4. SLEDAI-2K≥8 at screening.\n5. Are on a stable SLE SOC therapy consisting of any of the following medications for a period of at least 30 days prior to the first dose: glucocorticoid, and\u002For anti-malarials, and\u002For immunosuppressive agents.\n6. Have a positive test for anti-dsDNA antibody (\\> normal range) and\u002For anti-nuclear antibody (ANA) and\u002For anti-Smith antibody at screening.\n7. Women of childbearing potential must take a complementary barrier method of contraception in combination with a highly effective method of contraception at screening, throughout the trial, and within 90 days after the last dose of the investigational agent. In this trial.\n\nExclusion Criteria:\n\nMedical conditions:\n\n1. Pregnant or lactating women, and men or women who have birth plans in the past 12 months.\n2. Have neuropsychiatric systemic lupus erythematosus (NPSLE) within 6 months prior to the first dose, including seizures, psychosis, organic brain syndrome, cerebrovascular accident, cranial neuropathy, cerebritis, cerebral vasculitis or lupus headache.\n3. Have severe lupus nephritis, or have required hemodialysis or high-dose glucocorticoid within 90 days prior to the first dose.\n4. Have autoimmune diseases other than SLE (excluding secondary Sjogren's syndrome).\n5. Have a history of any non-SLE disease that has required treatment with oral or intravenous or intramuscular or subcutaneous injection glucocorticoids for more than a total of 2 weeks within the last 24 weeks prior to signing the ICF.\n6. Have a history of or current diagnosis of Central Nervous System (CNS) diseases.\n7. Have clinically documented cardiovascular diseases that are obviously unstable or not effectively treated.\n8. Have significant active lung diseases (e.g., interstitial lung disease, obstructive pulmonary disease).\n9. Have severe hepatobiliary diseases.\n10. Have a history of malignant neoplasm.\n11. Have a history of a major organ transplant or hematopoietic stem cell\u002Fmarrow transplant.\n12. Have known allergies to any component of the investigational agent as described in the Protocol.\n\n    Concomitant medication and surgery:\n13. Have received rituximab, epratuzumab, or any other B cell-depleting therapy within 12 months prior to randomization.\n14. Have received cyclophosphamide and chlorambucil within 6 months prior to randomization.\n15. Have received belimumab, tumor necrosis factor (TNF) blockers, interleukin receptor blockers or other biological agents within 3 months prior to randomization (or 5 half-lives, whichever is longer).\n\n    Lab tests:\n16. Have a positive test for human immunodeficiency virus (HIV) antibody.\n17. Have a positive test for Hepatitis B Surface Antigen (HBsAg) or hepatitis C antibody, or have a positive test for hepatitis B virus (HBV) DNA by Polymerase Chain Reaction (PCR) if positive for Hepatitis B Core Antibody (HBcAb).\n18. Have abnormal tissue or organ function, meeting any of the following at screening:\n\n    * Absolute neutrophil count (ANC) \\\u003C 1.5 × 10\\^9\u002FL; hemoglobin \\\u003C 90 g\u002FL; lymphocyte count \\\u003C 0.8 × 10\\^9 \u002FL.\n    * Calculated estimated glomerular filtration rate (eGFR) using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation \\\u003C 45 mL\u002Fmin\u002F1.73 m2.\n\n    Others:\n19. Have other conditions that are not appropriate for participation in the trial as considered by the investigator.","ALL","18 Years","75 Years",{"count":561,"type":562},186,"ESTIMATED","INTERVENTIONAL",[565],"PHASE2","This is a phase IIb, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of orelabrutinib in adult subjects with SLE who are receiving standard of care (SOC) therapy.",[568],"Systemic Lupus Erythematosus, SLE","2024-08-15",{"date":571,"type":572},"2024-08-16","ACTUAL",{"date":574,"type":572},"2023-04-29",{"date":576,"type":562},"2026-05-30",{"name":5,"class":6},41]