[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100573025":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":38,"locations":49,"responsibleParty":69,"collaborators":73,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":43,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":43,"studyType":91,"phases":92,"briefSummary":95,"conditions":96,"keywords":43,"overallStatus":52,"whyStopped":43,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Sahiwal medical college sahiwal","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Dexmedetomidine infusion","EXPERIMENTAL","inj dexmedetomidine infusion @ 0.2-0.4 μg\u002Fkg\u002Fh",[13],"Drug: inj. dexmedetomidine infusion @ 0.2-0.4 μg\u002Fkg\u002Fh",{"label":15,"type":10,"description":16,"interventionNames":17},"Lignocaine infusion","inj.lignocaine infusion @1-2 mg\u002Fkg\u002Fh",[18],"Drug: inj. lignocaine infusion @1-2 mg\u002Fkg\u002Fh",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","inj. dexmedetomidine infusion @ 0.2-0.4 μg\u002Fkg\u002Fh","Anesthesia induction will be done by doing pre-oxygenation for 3 minutes with 100% oxygen, propofol 2-2.5 mg\u002Fkg intravenous (IV) and nalbuphine 0.1mg\u002Fkg intravenous (IV). Tracheal intubation will be facilitated by succinylcholine 1.5 mg\u002Fkg IV. Anaesthesia will be maintained with isoflurane 0.6 mac, 60% nitrous oxide, 40% oxygen, atracurium 0.5mg\u002Fkg bolus followed by 0.15mg\u002Fkg maintenance dose every 30 mints until completion of surgery. Patients Intraoperative monitoring will include electrocardiogram leads II and V5, non-invasive blood pressure at 5 min intervals, oxygen saturation, end-tidal carbon dioxide and nasopharyngeal temperature. Patients will be ventilated by intermittent positive pressure ventilation using a circle system to maintain normocapnia. In group A, patients will be given inj. dexmedetomidine infusion @ 0.2-0.4 μg\u002Fkg\u002Fh intraoperatively",[9],[26],"Precedex",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"inj. lignocaine infusion @1-2 mg\u002Fkg\u002Fh","Anesthesia induction will be done by doing pre-oxygenation for 3 minutes with 100% oxygen, propofol 2-2.5 mg\u002Fkg intravenous (IV) and nalbuphine 0.1mg\u002Fkg intravenous (IV). Tracheal intubation will be facilitated by succinylcholine 1.5 mg\u002Fkg IV. Anaesthesia will be maintained with isoflurane 0.6 mac, 60% nitrous oxide, 40% oxygen, atracurium 0.5mg\u002Fkg bolus followed by 0.15mg\u002Fkg maintenance dose every 30 mints until completion of surgery. Patients Intraoperative monitoring will include electrocardiogram leads II and V5, non-invasive blood pressure at 5 min intervals, oxygen saturation, end-tidal carbon dioxide and nasopharyngeal temperature. Patients will be ventilated by intermittent positive pressure ventilation using a circle system to maintain normocapnia. In group A, patients will be given inj. lignocaine infusion @ 1-2 mg\u002Fkg\u002Fh intraoperatively",[15],[32],"Xylocaine",[34],{"name":35,"affiliation":36,"role":37},"Adeel Riaz, MD","Sahiwal Teaching Hospital, Sahiwal","STUDY_DIRECTOR",[39,45],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Tallal Shahid, MBBS","CONTACT","00923215006215",null,"tallalshahid@hotmail.com",{"name":46,"role":41,"phone":47,"phoneExt":43,"email":48},"Dr Muhammad Shahid, FCPS","00923336173056","shahidnishtar@gmail.com",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Sahiwal Medical College Sahiwal","RECRUITING","Sahiwal","Punjab Province","57000","Pakistan","PK",{"type":59,"coordinates":60},"Point",[61,62],73.10186,30.66595,{"lat":62,"lon":61},[65],{"name":66,"role":41,"phone":67,"phoneExt":43,"email":68},"Dr Rao Riaz ul Haq, FCPS","0092404502470","slmcswl@gmail.com",{"type":70,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"PRINCIPAL_INVESTIGATOR","Talal Shahid","Resident Anaesthetist",[74],{"name":75,"class":76},"Department of medical education","UNKNOWN","100573025","phase-2-evaluating-perioperative-outcomes-dexmedetomidine-vs-lignocaine-in-laparoscopic-chlolecystectomy-100573025",false,"NCT06740903","Evaluating Perioperative Outcomes: Dexmedetomidine vs Lignocaine in Laparoscopic Chlolecystectomy","Comparison of Dexmedetomidine & Lignocaine Infusion on Perioperative Hemodynamics, Postoperative Analgesia & Recovery of Postoperative Gastrointestinal Function in Patients for Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n1. Patients of age 20-70 years\n2. Both gender\n3. Laparoscopic cholecystectomy under general Anaesthesia\n4. ASA I-II.\n\nExclusion Criteria:\n\n* Emergency surgery\n* Patients with history of allergic reaction to trial drugs\n* Patients with cardiovascular disease, sickle cell disease, psychiatric disorder, peripheral vascular disease, and neurological diseases (on medical record)\n* Anemia\n* Patient on TCA or Beta blocker drugs.\n* Uncontrolled hypertension (P≥160\u002F100 mmHg)\n* Uncontrolled diabetes mellitus\n* Obesity BMI \\> 35",true,"ALL","20 Years","70 Years",{"count":89,"type":90},140,"ESTIMATED","INTERVENTIONAL",[93,94],"PHASE2","PHASE3","Nowadays laparoscopic surgery is the first choice for many surgeries. Such surgeries have revolutionized the surgical practice and has markedly reduced the incidence of intraoperative and postoperative complications. To minimize these side effects associated with the use of opioids, various methods have been adopted. Recently, different trials have highlighted the possible role of dexmedetomidine and lignocaine in providing postoperative analgesia and attenuating hemodynamic response. Literature showed conflicting results regarding both these drugs. So, we want to find the evidence for local setting. This Randomized Controlled Trial will be done at Department of Anesthesia, Sahiwal teaching hospital, Sahiwal for 12 months. Sample size of 140 cases; 70 cases in each group will be included through non-probability consecutive sampling. Then patients will be divided in two groups by using computer generated random number table. In group A, patients will be given dexmedetomidine infusion. In group B, patients will be given lignocaine infusion. All anesthesia procedures will be done by researcher. Heart rate and mean arterial pressure will be assessed before induction of anesthesia, after every 10 mins every 30 mins till completion of surgery. Total operative time will be noted. After procedure, patients will be assessed for postoperative pain score. when pain will be ≥4 on visual analogue scale rescue analgesia will be given and time will be noted. Total duration from time of surgery till need for rescue analgesia will be noted. Duration of postoperative analgesia opioid consumption \u002F24 hrs.) will be presented by using mean± SD.",[97,98,99,100],"Hemodynamics Instability","Post Operative Pain","Gastrointestinal Dysfunction","Cholecystitis","2024-12-14",{"date":103,"type":104},"2024-12-18","ACTUAL",{"date":106,"type":104},"2024-08-06",{"date":108,"type":90},"2025-09-06",{"name":5,"class":6},1]