[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606640":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":25,"locations":25,"responsibleParty":29,"collaborators":25,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":25,"eligibilityCriteria":39,"healthyVolunteers":35,"sex":40,"minAge":41,"maxAge":42,"enrollmentInfo":43,"targetDuration":25,"studyType":46,"phases":47,"briefSummary":49,"conditions":50,"keywords":52,"overallStatus":55,"whyStopped":25,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":25},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Modified Qing-Zao-Jiu-Fei Decoction (MQZJFD)","EXPERIMENTAL","A chinese medicine formular",[13],"Drug: Modified Qing-Zao-Jiu-Fei Decoction (MQZJFD)",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Placebo control",[19],"Drug: Placebo",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","MQZJFD is the core formula in this clinical study and consists of the 11 following herbs: Mori Folium 9g, Plaster stone 9g, Trichosanthis Fructus 9g, Ophiopogyonis Radix 6g, Armeniacae Semen Amarum 6g, Fritillariae Thunbergii Bulbus 6g, Eriobotryae Folium 6g, Ginseng Radix et Rhizoma 3g, Semen Sesami Nigrum 3g, Asini Corii Colla 3g, Glycyrrhizae Radix et Rhizoma 3g.\n\nThe formula will be prepared with single concentrated herbal granules (1 g of single concentrated herbal granule equates to 5 g of original dry herbs, except for Ophiopogyonis Radix whose ratio will be that 1 g of single concentrated herbal granule equals to 3 g of original dry herb, and Asini Corii Colla whose ratio will be that 1 g of single concentrated herbal granule equals to 1 g of original dry herb). The herbal granules will be provided by a Good Manufacturing Practice (GMP)-accredited supplier.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"The placebo granules consists of an inert substance made of starch filler, silica coating, flavor and coloring. Its appearance is unidentifiable to the real intervention drug. The placebo granules is also manufactured under GMP standards. To ensure blinding, the MQZJFD granules and placebo granules will be indistinguishable in appearance, smell and flavor.",[15],{"type":30,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","XIAN Yanfang","Prof. XIAN Yanfang, Assistant professor, School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong","100606640","phase-2-evaluating-the-efficacy-and-safety-of-modified-qing-zao-jiu-fei-decoction-on-pneumoconiosis-patients-100606640",false,"NCT07178184","Evaluating the Efficacy and Safety of Modified Qing-Zao-Jiu-Fei Decoction on Pneumoconiosis Patients","Evaluating the Efficacy and Safety of Modified Qing-Zao-Jiu-Fei Decoction on Pneumoconiosis Patients: A Randomized, Double-blinded, Placebo-Controlled Trial","Inclusion criteria\n\n1. Aged 20-85;\n2. Patients with pneumoconiosis (Confirmed case of pneumoconiosis by Pneumoconiosis compensation fund board);\n3. Agree to undergo blood test and willing to complete questionnaires and take medication as scheduled; and\n4. Willing to provide written informed consent.\n\nExclusion criteria\n\n1. Patient with the following Chinese medicine syndromes\u002Fpatterns according to Chinese medicine theory: dampness, lung deficiency and coldness, or Yang deficiency according to Chinese medicine theory;\n2. Patients receiving Chinese medicine in a regular pattern within the past 2 weeks;\n3. Patients with chronic co-morbidities such as other fibrotic lung diseases in addition to pneumoconiosis and\u002For co-existing heart disease;\n4. Patients with a medical history of malignancy within the past 5 years;\n5. Patients with a medical history of any serious diseases such as severe kidney and liver impairments, autoimmune disease, thyroid disease, Hodgkin's disease, lymphoma and leukemia;\n6. Patients with known severe cognitive and mental disorders;\n7. Documented pregnancy or lactation; or\n8. Patients allergic to the drug used in this study.","ALL","20 Years","85 Years",{"count":44,"type":45},80,"ESTIMATED","INTERVENTIONAL",[48],"PHASE2","This is a multicenter, randomized, double-blind, placebo-controlled study to investigate the beneficial efficacy and safety of Chinese medicine formula Modified Qing Zao Jiu Fei Decoction (MQZJFD) on pneumoconiosis patients. Participants will be randomized into one of the two groups (MQZJFD treatment group or placebo control group), and both undergo a consultation process by the Chinese Medicine practitioner (CMP). Eligible participants will be randomized and receive either MQZJFD granules or placebo granules for 16 weeks followed by post-treatment visits at week 20. The study will last for 20 weeks with a treatment period of 16 weeks plus a follow-up period of 4 weeks.",[51],"Pneumoconiosis",[53,54,51],"RCT","Chinese Medicine","NOT_YET_RECRUITING","2025-09-15",{"date":58,"type":59},"2025-09-17","ACTUAL",{"date":61,"type":45},"2025-11-01",{"date":63,"type":45},"2027-04-30",{"name":5,"class":6}]