[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100540128":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":35,"locations":41,"responsibleParty":62,"collaborators":26,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":26,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":26,"enrollmentInfo":74,"targetDuration":26,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":26,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Wright State University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Imipramine and Vehicle","EXPERIMENTAL","4% imipramine and vehicle are applied on a 2x2cm2 area of the subject's cheek. The imipramine is applied on one side of the subject's face (cheek) and vehicle is applied on the other side.",[13,14],"Drug: Imipramine","Drug: Vehicle",{"label":16,"type":10,"description":17,"interventionNames":18},"Amitriptyline and Vehicle","4% amitriptyline and vehicle are applied on a 2x2cm2 area of the subject's cheek. The amitriptyline is applied on side of the subject's face (cheek) and vehicle is applied on the other side.",[19,14],"Drug: Amitriptyline",[21,27,31],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Imipramine","4% imipramine",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Amitriptyline","4% amitriptyline",[16],{"type":22,"name":32,"description":33,"armGroupLabels":34,"otherNames":26},"Vehicle","0.1ml propylene glycol",[16,9],[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Manager Clinical Research Operations","CONTACT","(937)-245-7500","pturesearch@wrightstatephysicians.org",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Wright State Physicians","RECRUITING","Fairborn","Ohio","45324","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-84.01938,39.82089,{"lat":54,"lon":53},[57,59],{"name":58,"role":38,"phone":39,"phoneExt":26,"email":40},"Pharmacology Translational Unit",{"name":60,"role":61,"phone":26,"phoneExt":26,"email":26},"Travers","PRINCIPAL_INVESTIGATOR",{"type":63,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100540128","phase-2-evaluating-use-of-topical-imipramine-and-amitriptyline-in-reducing-ultraviolet-b-light-induced-redness-in-patients-with-rosacea-100540128",false,"NCT06312813","Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea","Pilot Studies Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea","Inclusion Criteria:\n\n* Fitzpatrick Skin Type I - IIII\n* Self-identified rosacea or no history of flushing\u002Fblushing for controls\n* Able to provide medical history and list of medications -- control subjects will not be allowed to take medications that are known to be photosensitizers.\n\nExclusion Criteria:\n\n* Using imipramine, amitriptyline or any other tricyclic antidepressant (oral or topical)\n* Using topical anti-inflammatory (within 1 week) or systemic agents (e.g. prednisone)\n* Large tattoos in the designated testing areas\n* Tanning bed use within last 3 months\n* Photodynamic Therapy or UCB treatments in past 3 months\n* Female Subjects: pregnant or nursing",true,"ALL","18 Years",{"count":75,"type":76},48,"ESTIMATED","INTERVENTIONAL",[79],"PHASE2","Rosacea is a common skin condition associated with easy blushing and red face; many patients with rosacea react to sunlight with increased redness. The purpose of this study is to determine if the use of a topical medication will help reduce sunlight induced redness and irritation in patients with rosacea.",[82],"Rosacea","2026-02-17",{"date":85,"type":86},"2026-02-18","ACTUAL",{"date":88,"type":86},"2024-02-27",{"date":90,"type":76},"2028-12-01",{"name":5,"class":6},1]