[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100598892":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":64,"collaborators":11,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":11,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":41,"whyStopped":11,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"elinzanetant 120 mg daily for 12 weeks","ACTIVE_COMPARATOR",null,[13],"Drug: elinzanetant - reference formulation",{"label":15,"type":16,"description":11,"interventionNames":17},"Placebo daily for 12 weeks","PLACEBO_COMPARATOR",[18],"Drug: placebo",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","elinzanetant - reference formulation","elinzanetant 120 mg daily x 12 weeks",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"placebo","placebo daily x 12 weeks",[15],[30],{"name":31,"affiliation":5,"role":32},"Emily Lau, MD, MPH","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":11,"email":38},"Kamila Bielawski","CONTACT","617-724-3064","mghflashcv@mgb.org",[40,55],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Boston","Massachusetts","02114","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-71.05977,42.35843,{"lat":51,"lon":50},[54],{"name":35,"role":36,"phone":37,"phoneExt":11,"email":38},{"facility":56,"status":41,"city":42,"state":43,"zip":57,"country":45,"countryCode":46,"cosmosGeoPoint":58,"geoPoint":60,"contacts":61},"Brigham and Women's Hospital","02115",{"type":48,"coordinates":59},[50,51],{"lat":51,"lon":50},[62],{"name":35,"role":36,"phone":63,"phoneExt":11,"email":38},"617-643-6161",{"type":32,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Emily Lau","Principal Investigator","100598892","phase-2-finding-links-between-hot-flashes-and-cardiovascular-disease-100598892",false,"NCT07077395","Finding Links Between Hot flASHes and CardioVascular Disease","FLASH-CV:","Inclusion Criteria:\n\n* Age 40-65 years\n* Peri- and post-menopausal women (STRAW -1 to +1)\n* Moderate or high vasmotor symptom burden\n* Cardiometabolic disease (as evidenced by ≥ 2 of the following):\n\n  * Obesity (body mass index ≥ 30 kg\u002Fm2)\n  * Elevated waist circumference (≥ 88 cm)\n  * Elevated triglycerides (≥ 150 mg\u002FdL or drug treatment)\n  * Reduced HDL-cholesterol (\\\u003C50 mg\u002FdL or drug treatment)\n  * Elevated blood pressure (≥ 130 mmHg systolic blood pressure or ≥ 85 mmHg diastolic blood pressure, or drug treatment)\n  * Elevated fasting glucose (≥ 100 mg\u002FdL or drug treatment)\n\nExclusion Criteria:\n\n* Inability to provide informed consent or comply with study protocol\n* Major comorbidities: cancer, end-stage renal (eGFR \\\u003C45 mL\u002Fmin\u002F1.73 m2), liver or lung disease\n* Concomitant use of strong or moderate cytochrome P450 3A4 inhibitors\n* Elevated liver function tests (ALT, AST, and\u002For total bilirubin ≥2x ULN)\n* Undiagnosed uterine bleeding over past 6 months","FEMALE","40 Years","65 Years",{"count":78,"type":79},80,"ESTIMATED","INTERVENTIONAL",[82],"PHASE2","The goal of this clinical trial is to learn if neurokinin-1\u002Fneurokinin-3 receptor antagonist elinzanetant improves blood vessel health in women with moderate to severe hot flashes. The main questions it aims to answer is does neurokinin-1\u002Fneurokinin-3 receptor antagonist elinzanetant improve blood vessel health?",[85],"Menopause-related Hot Flashes",[87,88,89],"menopause","hot flashes","heart health","2026-05-18",{"date":92,"type":93},"2026-05-20","ACTUAL",{"date":95,"type":93},"2026-03-01",{"date":97,"type":79},"2029-09",{"name":5,"class":6},2]