[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100607406":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":36,"centralContacts":37,"locations":47,"responsibleParty":64,"collaborators":36,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":36,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":36,"studyType":81,"phases":82,"briefSummary":85,"conditions":86,"keywords":92,"overallStatus":98,"whyStopped":36,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Margalla Institute of Health Sciences","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active Comparator: Group A (Gluma Desensitizer Group)","ACTIVE_COMPARATOR","Patients receiving Gluma desensitizer followed by universal bonding agent and composite restoration on Class I carious lesions.",[13],"Drug: Drug\u002FAgent: Gluma Desensitizer",{"label":15,"type":10,"description":16,"interventionNames":17},"Active Comparator: Group B (Control Group)","Patients receiving universal bonding agent and composite restoration without Gluma desensitizer on Class I carious lesions.",[18],"Drug: Drug\u002FAgent: No desensitizer (Control)",[20,29],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Drug\u002FAgent: Gluma Desensitizer","Gluma desensitizer applied to prepared tooth surface, followed by universal bonding agent and composite restoration. Application done during the first visit of restorative treatment. Post-operative sensitivity measured at baseline, 1 week, 1 month, and 3 months.",[9],[26,27,28],"Gluma","Glutaraldehyde\u002FHEMA solution","Dentin desensitizer",{"type":21,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Drug\u002FAgent: No desensitizer (Control)","Universal bonding agent applied followed by composite restoration without prior use of Gluma desensitizer. Post-operative sensitivity measured at baseline, 1 week, 1 month, and 3 months.",[15],[34,35],"Control group","Composite restoration without desensitizer",null,[38,43],{"name":39,"role":40,"phone":41,"phoneExt":36,"email":42},"Dr. Beenish Hassan","CONTACT","+92 333 9502970","beenishhassan2000@gmail.com",{"name":44,"role":40,"phone":45,"phoneExt":36,"email":46},"Dr. Sana Jalil Hasan","+92 334 5296968","sanahasanjalil5@gmail.com",[48],{"facility":49,"status":36,"city":50,"state":51,"zip":36,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Margalla Institute of Health Sciences Quaid e Azam Avenue, Gulraiz phase 3, Gulraiz Housing Scheme, Rawalpindi","Rawalpindi","Punjab Province","Pakistan","PK",{"type":55,"coordinates":56},"Point",[57,58],73.0479,33.59733,{"lat":58,"lon":57},[61,62],{"name":39,"role":40,"phone":41,"phoneExt":36,"email":42},{"name":39,"role":63,"phone":36,"phoneExt":36,"email":36},"PRINCIPAL_INVESTIGATOR",{"type":65,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":36,"oldOrganization":36},"SPONSOR_INVESTIGATOR","Beenish Hassan","Post Graduate Trainee","100607406","phase-2-gluma-compared-with-bonding-agent-for-post-operative-sensitivity-following-composite-restorations-100607406",false,"NCT07188142","Gluma Compared With Bonding Agent for Post-operative Sensitivity Following Composite Restorations","Investigating the Effects of Two Different Desensitizing Agents on Mitigating Post-Operative Sensitivity Following Composite Restorations - a Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 18-45 years.\n* Good oral hygiene.\n* Active primary class I carious lesions on vital molar teeth with ICDAS score 3\n* Patients complaining of sensitivity to air and osmotic stimulus.\n* Teeth having a positive cold test.\n* No signs of pulp inflammation or spontaneous pain before treatment.\n\nExclusion Criteria:\n\n* Excessive tooth wear due to clenching or abnormal habits.\n* Traumatic occlusion.\n* Periodontal or gingival disease.\n* Patients using analgesics and\u002For anti-inflammatory medicine.","ALL","18 Years","45 Years",{"count":79,"type":80},60,"ESTIMATED","INTERVENTIONAL",[83,84],"PHASE2","PHASE3","* The aim of this study is to compare the effectiveness of Gluma desensitizer in reducing post-operative sensitivity following composite restorations in posterior teeth. -Patients visiting OPD will be selected after fulfilment of inclusion criteria. Patients aged 18-45 meeting inclusion criteria and presenting with active primary class I carious lesions on vital molar teeth with ICDAS score 3 will be randomly assigned into two groups: -Group A: Patients will be provided with Gluma desensitizer, Universal Bonding agent and Composite restoration and -Group B: Patients will receive Universal bonding agent and Composite restoration. -The progress of treatment will be followed up immediately (baseline) and at regular follow up visits at 1 week, 1 month and 3 months.\n* Post-operative sensitivity will be assessed using an air stimulus and rated on a numeric rating scale for post-operative sensitivity assessment ranging from 0 to 10.",[87,88,89,90,91],"Post-operative Sensitivity","Dentin Hypersensitivity","Dental Caries","Tooth Sensitivity After Composite Restorations","Post-operative Sensitivity After Class I Composite Restorations",[93,94,95,96,97],"Post-operative sensitivity","Dentinal hypersensitivity","Class I caries","Gluma desensitizer","Composite restoration","NOT_YET_RECRUITING","2025-09-19",{"date":101,"type":102},"2025-09-23","ACTUAL",{"date":104,"type":80},"2025-12-01",{"date":106,"type":80},"2026-06-01",{"name":66,"class":6},1]