[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571414":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":145,"collaborators":148,"id":151,"slug":152,"hasResults":153,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":153,"sex":159,"minAge":160,"maxAge":161,"enrollmentInfo":162,"targetDuration":26,"studyType":165,"phases":166,"briefSummary":169,"conditions":170,"keywords":172,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":185},{"fullName":5,"class":6},"Universidade Federal do Rio Grande do Norte","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active HD-tDCS Group","EXPERIMENTAL","Patients randomly included in this group will receive 10 sessions of anodal HD-tDCS stimulation. The intervention will take place at the participant's home, with electrodes positioned in a circular arrangement-one central electrode and four peripheral electrodes-over the cortical representation zone of the left primary diaphragmatic motor cortex, with a continuous current applied",[13],"Device: Active HD-tDCS",{"label":15,"type":16,"description":17,"interventionNames":18},"HD-tDCS sham group","PLACEBO_COMPARATOR","Patients randomly included in this group will receive 10 sessions of sham HD-tDCS stimulation. The intervention will take place at the participant's home, with electrodes positioned in a circular arrangement-one central electrode and four peripheral electrodes-over the cortical representation zone of the left primary diaphragmatic motor cortex. Only an initial 30-second ramp stimulus will be applied, followed by a non-effective current",[19],"Device: Simulated HD-tDCS",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Active HD-tDCS","10 sessions of anodal HD-tDCS stimulation (neurostimulator coupled with a 4x1 HD-tDCS multichannel adapter) with a defined electrical current intensity over the cortical representation zone of the left diaphragmatic motor cortex",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Simulated HD-tDCS","10 sessions of sham anodal HD-tDCS stimulation (neurostimulator coupled with a 4x1 HD-tDCS multichannel adapter) over the cortical representation zone of the left diaphragmatic motor cortex. The device will provide a 30-second ramp and then maintain a minimal, non-effective continuous current",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Guilherme A. F Fregonezi, PhD","CONTACT","+55(84)99426-7896","guilherme.fregonezi@ufrn.br",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Edna K. F Laurentino, MSc","+55(84)99471-5172","ednakarlaferreira@gmail.com",[42,68,109,130],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Universidade de Brasília - Campus Ceilândia","RECRUITING","Brasília","Federal District","72220-275","Brazil","BR",{"type":51,"coordinates":52},"Point",[53,54],-47.92972,-15.77972,{"lat":54,"lon":53},[57,61,63,66],{"name":58,"role":34,"phone":59,"phoneExt":26,"email":60},"Vinicius Z Maldaner da Silva, PhD","+55 61 99652-2517","pneumocardiovascularlab@gmail.com",{"name":58,"role":62,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"name":64,"role":65,"phone":26,"phoneExt":26,"email":26},"Sergio R. M Mateus, PhD","SUB_INVESTIGATOR",{"name":67,"role":65,"phone":26,"phoneExt":26,"email":26},"Hamilton C Fernandes Franco, PhD",{"facility":69,"status":44,"city":70,"state":71,"zip":72,"country":48,"countryCode":49,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"PneumoCardioVascular Lab - HUOL\u002FUFRN","Natal","Rio Grande do Norte","59010-090",{"type":51,"coordinates":74},[75,76],-35.20944,-5.795,{"lat":76,"lon":75},[79,82,85,86,88,89,91,93,95,97,99,101,103,105,107],{"name":33,"role":34,"phone":80,"phoneExt":81,"email":60},"+55 84 3092-3624","3624",{"name":83,"role":34,"phone":84,"phoneExt":26,"email":40},"Edna K Ferreira Laurentino, MSc","+55 084 99471-5172",{"name":33,"role":62,"phone":26,"phoneExt":26,"email":26},{"name":87,"role":62,"phone":26,"phoneExt":26,"email":26},"Ana Rodrigues Lindquist, PhD",{"name":83,"role":65,"phone":26,"phoneExt":26,"email":26},{"name":90,"role":65,"phone":26,"phoneExt":26,"email":26},"Wesley R Costa Meneses, BSc",{"name":92,"role":65,"phone":26,"phoneExt":26,"email":26},"Mario E Teixeira Dourado Junior, PhD",{"name":94,"role":65,"phone":26,"phoneExt":26,"email":26},"Lariza M da Costa, BSc",{"name":96,"role":65,"phone":26,"phoneExt":26,"email":26},"Vanessa R. F Resqueti, PhD",{"name":98,"role":65,"phone":26,"phoneExt":26,"email":26},"Danilo A. A Pinto Nagem, PhD",{"name":100,"role":65,"phone":26,"phoneExt":26,"email":26},"Mario E. T Dourado Junior, PhD",{"name":102,"role":65,"phone":26,"phoneExt":26,"email":26},"Suellen M. M dos Santos Andrade, PhD",{"name":104,"role":65,"phone":26,"phoneExt":26,"email":26},"Ricardo A de Medeiros Valentim, PhD",{"name":106,"role":65,"phone":26,"phoneExt":26,"email":26},"Rodrigo P de Abreu Freitas, PhD",{"name":108,"role":65,"phone":26,"phoneExt":26,"email":26},"Bruna R Carneiro de Sousa, MSc",{"facility":110,"status":111,"city":112,"state":113,"zip":114,"country":115,"countryCode":116,"cosmosGeoPoint":117,"geoPoint":121,"contacts":122},"Universidad Autónoma de Chile","NOT_YET_RECRUITING","Santiago","Santiago Metropolitan","7500912","Chile","CL",{"type":51,"coordinates":118},[119,120],-70.64827,-33.45694,{"lat":120,"lon":119},[123,127,128],{"name":124,"role":34,"phone":125,"phoneExt":26,"email":126},"Matias Otto Yañez, PhD","+56 9 8885-6626","matiasotto.kine@gmail.com",{"name":124,"role":34,"phone":125,"phoneExt":26,"email":26},{"name":129,"role":62,"phone":26,"phoneExt":26,"email":26},"Matias V Oto Yañez, PhD",{"facility":131,"status":111,"city":112,"state":113,"zip":132,"country":115,"countryCode":116,"cosmosGeoPoint":133,"geoPoint":135,"contacts":136},"Universidad do Chile","8380453",{"type":51,"coordinates":134},[119,120],{"lat":120,"lon":119},[137,140,143,144],{"name":138,"role":34,"phone":26,"phoneExt":26,"email":139},"Roberto Vera Uribe, MsC","robertovera@uchile.cl",{"name":141,"role":34,"phone":26,"phoneExt":26,"email":142},"Rodrigo Torres Castro, MsC","klgorodrigotorres@gmail.com",{"name":138,"role":62,"phone":26,"phoneExt":26,"email":26},{"name":141,"role":62,"phone":26,"phoneExt":26,"email":26},{"type":62,"investigatorFullName":146,"investigatorTitle":147,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Guilherme Augusto de Freitas Fregonezi","Professor, PhD",[149],{"name":150,"class":6},"Financiadora de Estudos e Projetos","100571414","phase-2-hd-tdcs-in-amyotrophic-lateral-sclerosis-a-multicenter-randomized-controlled-trial-100571414",false,"NCT06719947","HD-tDCS in Amyotrophic Lateral Sclerosis: A Multicenter Randomized Controlled Trial","High-Definition Transcranial Direct Current Stimulation (HD-tDCS) in Amyotrophic Lateral Sclerosis: A Multicenter Randomized Controlled Trial","tDCS-ALS","Inclusion Criteria:\n\n* Both sexes; diagnosis of ALS according to the revised El Escorial criteria;\n* Age between 18 and 80 years;\n* Forced Vital Capacity greater than 50% of predicted;\n* Sniff nasal inspiratory pressure greater than 40 cmH2O;\n* A telephone number to contact the care team and who signed the study consent form.\n\nExclusion Criteria:\n\n* Subjects who are unable to understand or perform any of the study procedures;\n* Subjects who do not agree to participate or voluntarily request withdrawal from the study at any time;\n* Subjects with cardiac, respiratory, or musculoskeletal comorbidities;\n* Subjects using invasive mechanical ventilation;\n* Subjects with a tracheostomy;\n* Subjects with a pacemaker;\n* Subjects with metallic brain implants or other electronic implants;\n* Subjects with a cochlear implant;\n* Subjects with epileptic activity or a history of epilepsy, or a family history of epilepsy;\n* Subjects with a history of stroke or tumor;\n* Subjects prone to severe hemodynamic fluctuations, acute infectious processes, and\u002For inflammatory conditions;\n* Pregnant women at the time of recruitment;\n* Subjects who are unable to complete the intervention protocol.","ALL","18 Years","80 Years",{"count":163,"type":164},80,"ESTIMATED","INTERVENTIONAL",[167,168],"PHASE2","PHASE3","Amyotrophic Lateral Sclerosis (ALS) is a nervous system disease that causes muscle weakness and rapidly progresses to the loss of mobility and functionality. Studies suggest that High-Definition Transcranial Direct Current Stimulation (HD-tDCS) is a technique for modulating motor cortical hyperexcitability. However, evidence on the use of HD-tDCS as a neuromodulator of the diaphragmatic motor cortex in people with ALS is inconclusive.",[171],"Amyotrophic Lateral Sclerosis (ALS)",[171,173,174,175],"Central Nervous System Diseases","Electric Stimulation Therapy","Transcranial Direct Current Stimulation","2026-06-25",{"date":178,"type":179},"2026-06-29","ACTUAL",{"date":181,"type":179},"2025-11-28",{"date":183,"type":164},"2028-09-01",{"name":5,"class":6},4]