[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609345":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":11,"centralContacts":23,"locations":29,"responsibleParty":46,"collaborators":11,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":52,"sex":58,"minAge":59,"maxAge":11,"enrollmentInfo":60,"targetDuration":11,"studyType":63,"phases":64,"briefSummary":67,"conditions":68,"keywords":73,"overallStatus":32,"whyStopped":11,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Rigshospitalet, Denmark","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Low dose Dexamethasone (8mg)","ACTIVE_COMPARATOR",null,[13],"Drug: Dexamethasone",{"label":15,"type":10,"description":11,"interventionNames":16},"High dose Dexamethasone (1mg\u002Fkg)",[13],[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":11},"DRUG","Dexamethasone","Patients will receive either low dose (8mg) or high dose (1mg\u002Fkg)",[15,9],[24],{"name":25,"role":26,"phone":27,"phoneExt":11,"email":28},"Lasse Visby, Medical Doctor","CONTACT","+4522246982","lasse.visby@regionh.dk",[30],{"facility":31,"status":32,"city":33,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Department for Cardiothoracic Surgery, Rigshospitalet","RECRUITING","Copenhagen","2100","Denmark","DK",{"type":38,"coordinates":39},"Point",[40,41],12.56553,55.67594,{"lat":41,"lon":40},[44],{"name":25,"role":26,"phone":45,"phoneExt":11,"email":28},"+45 22246982",{"type":47,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Lasse Visby","Co-investigator","100609345","phase-2-high-dose-dexamethasone-to-reduce-postoperative-pain-after-video-assisted-thoracoscopic-surgery-lobectomy-segmentectomy-100609345",false,"NCT07213375","High Dose Dexamethasone to Reduce Postoperative Pain After Video-Assisted Thoracoscopic Surgery Lobectomy \u002FSegmentectomy","High Dose Dexamethasone In High-Pain Responders Undergoing Enhanced Recovery Video-Assisted Thoracoscopic Surgery Lobectomy and Segmentectomy - A Randomized Double-Blinded Controlled Trial","DEXTER","Inclusion Criteria:\n\n* Age ≥ 18 year\n* Able to understand written and spoken Danish language\n* PCS ≥20\n* Signed written informed consent form.\n* Patient planned to elective VATS lobectomy\u002Fsegmentectomy\n\nExclusion Criteria:\n\n* Patients undergoing systemic glucocorticoid or other immunosuppressive therapies, ex-cluding inhaled steroids.\n\n  * Individuals with diabetes requiring insulin treatment.\n  * Pregnant or breastfeeding patients.\n  * Patients with known allergies to the study drug.\n  * Individuals with mental disabilities that may impair their capacity to provide informed consent or compromise the validity of data collection.\n  * Patients with diagnosed schizophrenia, active psychosis, bipolar disorder, or a history of ongoing treatment with antipsychotic and\u002For antidepressant medications.\n  * Individuals with altered pain perception due to other conditions or injuries, such as spi-nal cord or brain injuries, severe polyneuropathies, or neurological disorders.\n  * Regular users of opioid medications.\n  * Patients requiring reoperation within the first two postoperative days.\n  * Individuals undergoing conversion to a surgical procedure other than VATS lobecto-my\u002Fsegmentectomy.","ALL","18 Years",{"count":61,"type":62},80,"ESTIMATED","INTERVENTIONAL",[65,66],"PHASE2","PHASE3","The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg\u002Fkg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to \"High-pain-responders\" in patients undergoing VATS lobectomy\u002Fsegmentectomy.\n\nThe hypothesis is that a high dose of Dexamethasone can lower pain when coughing in the morning after VATS lobectomy\u002Fsegmentectomy, in patients scoring as \"High-pain-responders\" on the Pain-Catastrophizing-Scale",[69,70,71,72],"Analgetic","Lung Cancer (NSCLC)","Video Assisted Thoracic Surgery (VATS)","Glucocorticoid",[74,75,76,77,78],"Pain catastrophizing","ERAS","VATS","Lung cancer","Minimizing pain","2026-01-05",{"date":81,"type":82},"2026-01-07","ACTUAL",{"date":84,"type":82},"2025-09-01",{"date":86,"type":62},"2026-11",{"name":5,"class":6},1]