[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100401343":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":41,"centralContacts":46,"locations":52,"responsibleParty":69,"collaborators":27,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":27,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":27,"enrollmentInfo":81,"targetDuration":27,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":54,"whyStopped":27,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Vanderbilt-Ingram Cancer Center","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Group I (UH HRT)","EXPERIMENTAL","Patients undergo HRT daily for a total of 5 fractions followed by surgery.",[13,14,15],"Radiation: Ultra-Hypo-fractionation Radiotherapy","Procedure: Resection","Other: Questionnaire Administration",{"label":17,"type":10,"description":18,"interventionNames":19},"Group II (MH HRT)","Patients undergo HRT daily for a total of 15 fractions followed by surgery.",[14,15,20],"Radiation: Moderately-Hypo-fractionation Radiotherapy",[22,28,33,37],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"RADIATION","Ultra-Hypo-fractionation Radiotherapy","Five fractions of pre-operative radiation",[9],null,{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":27},"PROCEDURE","Resection","Surgery",[9,17],{"type":6,"name":34,"description":35,"armGroupLabels":36,"otherNames":27},"Questionnaire Administration","Ancillary studies",[9,17],{"type":23,"name":38,"description":39,"armGroupLabels":40,"otherNames":27},"Moderately-Hypo-fractionation Radiotherapy","15 fractions of pre-operative radiation",[17],[42],{"name":43,"affiliation":44,"role":45},"Eric Shinohara, MD","Vanderbilt Medical Center","PRINCIPAL_INVESTIGATOR",[47],{"name":48,"role":49,"phone":50,"phoneExt":27,"email":51},"Vanderbilt-Ingram Service for Timely Access","CONTACT","800-811-8480","cip@vumc.org",[53],{"facility":5,"status":54,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"RECRUITING","Nashville","Tennessee","37232","United States","US",{"type":61,"coordinates":62},"Point",[63,64],-86.78444,36.16589,{"lat":64,"lon":63},[67,68],{"name":48,"role":49,"phone":50,"phoneExt":27,"email":51},{"name":43,"role":45,"phone":27,"phoneExt":27,"email":27},{"type":45,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"Eric Shinohara","Principal Investigator","100401343","phase-2-hypofractionated-radiotherapy-followed-by-surgical-resection-in-the-treatment-of-soft-tissue-sarcomas-100401343",false,"NCT04506008","Hypofractionated Radiotherapy Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas","Prospective Observational Trial of Two Neoadjuvant Hypofractionated Radiotherapy Regimens Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas","Inclusion Criteria:\n\n* Histologic diagnosis of a soft tissue sarcoma of extremity, pelvis, chest wall or trunk\u002Fabdominal wall (non-retroperitoneal location)\n* ECOG performance status 0-2\n* Patient must be deemed able to comply with radiation treatment and surgery\n\nExclusion Criteria:\n\n* History of prior radiation to the same area to be irradiated\n* Pregnancy\n* Active collagen vascular disease or patients genetically predisposed to increased radiation related side effects","ALL","18 Years",{"count":82,"type":83},40,"ESTIMATED","INTERVENTIONAL",[86],"PHASE2","The trial will use neoadjuvant hypofractionated radiotherapy followed by surgical resection in the treatment for soft tissue sarcoma. It will allow patients to be treated over a shorter course (5 or 15 days of radiation) compared to the traditional 5 week regimen. It is proposed that this will be possible without increasing the risk of wound complication or local recurrence compared with a traditional 5 week course of pre-operative radiation.",[89],"Soft Tissue Sarcomas",[91],"Hypofractionated Radiotherapy","2025-03-24",{"date":94,"type":95},"2025-03-28","ACTUAL",{"date":97,"type":95},"2021-03-02",{"date":99,"type":83},"2027-06",{"name":5,"class":6},1]