[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100585072":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":40,"responsibleParty":53,"collaborators":25,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":25,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":25,"enrollmentInfo":65,"targetDuration":25,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":25,"overallStatus":43,"whyStopped":25,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Mansoura University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Dapagliflozin + ESA group","EXPERIMENTAL","patients will receive dapagliflozin 10 mg tablet once daily in addition to standard care therapy of erythropoiesis-stimulating agents (ESA)",[13,14],"Drug: Dapagliflozin (DAPA)","Drug: Erythropoiesis Stimulating Agent",{"label":16,"type":6,"description":17,"interventionNames":18},"Control group","patients will receive standard care therapy of erythropoiesis-stimulating agents (ESA)",[14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Dapagliflozin (DAPA)","Dapagliflizin 10 mg tablets once daily for 12 weeks",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Erythropoiesis Stimulating Agent","Erythropoiesis stimulating agent (ESA) therapy",[16,9],[31],{"name":32,"affiliation":5,"role":33},"Noha O. Mansour, Ph.D.","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Basma M. Sayed Ahmed, M.Sc.","CONTACT","+201207753307","basma_mohamed@mans.edu.eg",[41],{"facility":42,"status":43,"city":44,"state":25,"zip":25,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":25},"Urology and Nephrology Center","RECRUITING","Al Mansurah","Egypt","EG",{"type":48,"coordinates":49},"Point",[50,51],31.38069,31.03637,{"lat":51,"lon":50},{"type":33,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Noha Mansour","Principal investigator-Associate Professor of Clinical Pharmacy-Clinical Pharmacy and Pharmacy Practice Department","100585072","phase-2-impact-of-dapagliflozin-in-anemic-chronic-kidney-disease-patients-100585072",false,"NCT06897605","Impact of Dapagliflozin in Anemic Chronic Kidney Disease Patients","Clinical Study Evaluating the Impact of Dapagliflozin on Erythropoiesis-Stimulating Agent Responsiveness in Anemic Patients With Chronic Kidney Disease","Inclusion criteria\n\n1. Adults aged ≥ 18 years with CKD stage III or IV.\n2. Patients with anemia of CKD and a hemoglobin level \\\u003C 11.5 g\u002FdL\n3. Patients are receiving erythropoiesis-stimulating agent therapy.\n\nExclusion criteria\n\n1. Anemia due to causes other than chronic kidney disease, such as pernicious anemia, thalassemia, sickle cell anemia, or myelodysplastic syndromes.\n2. Patients with severe ketosis, diabetic coma, severe infection, perioperative complications, or severe trauma.\n3. Patients with acute heart failure, acute myocardial infarction, or stroke occurring within 6 months before enrollment in the trial.\n4. Patients with current malignancies or a history of malignancy within the past 2 years.\n5. Diagnosed with pure red cell aplasia.\n6. Patients with severe gastrointestinal bleeding.\n7. Pregnant or lactating females.","ALL","18 Years",{"count":66,"type":67},80,"ESTIMATED","INTERVENTIONAL",[70],"PHASE2","Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor, primarily used in the management of type 2 diabetes mellitus. Emerging research suggests that SGLT2 inhibitors may offer additional benefits, including reducing the risk of cardiovascular events and renal complications. Post hoc analyses of previous clinical trials have shown that patients treated with SGLT2 inhibitors exhibited higher levels of hemoglobin and hematocrit compared to those in the control group. These findings suggest that dapagliflozin's ability to elevate hemoglobin levels could potentially be utilized for the treatment of anemia in patients with chronic kidney disease.",[73,74],"Chronic Kidney Disease(CKD)","Anemia, Kidney Disease, Chronic","2025-03-27",{"date":77,"type":78},"2025-04-02","ACTUAL",{"date":80,"type":67},"2025-04-01",{"date":82,"type":67},"2025-10",{"name":5,"class":6},1]