[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589181":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":34,"locations":45,"responsibleParty":61,"collaborators":24,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":24,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":24,"studyType":76,"phases":77,"briefSummary":80,"conditions":81,"keywords":24,"overallStatus":48,"whyStopped":24,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"group 1a IPSC transplant in portal circulation","EXPERIMENTAL","Insulin producing stem cells injection in portal circulation",[13],"Biological: Insulin producing stem cells infusion",{"label":15,"type":10,"description":16,"interventionNames":17},"group 1b IPSC in peripheral systemic circulation","Insulin producing stem cells injection in peripheral systemic circulation",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"BIOLOGICAL","Insulin producing stem cells infusion","1. Liposuction of the anterior abdominal subcutaneous fat layer of participant\n2. Characterization and Identification of mesenchymal stem cells\n3. Differentiation of mesenchymal stem cells into insulin producing stem cells\n4. In vitro detection of Insulin and c-peptide in differentiated MSC (Confirmatory tests for the insulin producing cells)\n5. In vitro Insulin and c-peptide release detection in differentiated MSC in response to increasing glucose concentrations Differentiated MSCs injection in human subjects\n6. Followup",[9,15],null,[26,30],{"name":27,"affiliation":28,"role":29},"Rasha S Elmetwally, A. Prof","Assistant professor of Pediatrics, Faculty of Medicine, Ain Shams University","PRINCIPAL_INVESTIGATOR",{"name":31,"affiliation":32,"role":33},"Randa M Matter, Prof","Professor of pediatrics, Faculty of Medicine, Ain Shams University","STUDY_DIRECTOR",[35,41],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},"Rasha S Elmetwally, MD","CONTACT","20201092143033","02","dr.rashaeladawy@med.asu.edu.eg",{"name":42,"role":37,"phone":43,"phoneExt":39,"email":44},"Rasha S Eladawy, MD","01092143033","Rashaeladawy1@gmail.com",[46],{"facility":47,"status":48,"city":49,"state":24,"zip":24,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Children Hospital Eldemerdash","RECRUITING","Cairo","Egypt","EG",{"type":53,"coordinates":54},"Point",[55,56],31.24967,30.06263,{"lat":56,"lon":55},[59],{"name":60,"role":37,"phone":38,"phoneExt":24,"email":40},"Rasha Eladawy Shaaban Elmetwally, MD",{"type":62,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100589181","phase-2-insulin-producing-stem-cell-transplantation-clinical-trial-in-type-1-diabetes-100589181",false,"NCT06951074","Insulin Producing Stem Cell Transplantation Clinical Trial in Type 1 Diabetes","Autologous Insulin Producing Mesenchymal Stem Cell Transplantation in Youth With Type 1 Diabetes","Inclusion Criteria:\n\n* Type 1 diabetes\n\nExclusion Criteria:\n\n* patients with other autoimmune diseases\n* patients with micro or macro vascular complications\n* patients with other chronic diseases","ALL","15 Years","18 Years",{"count":74,"type":75},20,"ESTIMATED","INTERVENTIONAL",[78,79],"PHASE2","PHASE3","Type 1 Diabetes is a chronic autoimmune disease. It results from autoimmune destruction of pancreatic Beta cells leading to absolute insulin insufficiency. The establishment of pluripotent like human stem cells derived from adipose tissue derived mesenchymal cell origin have introduced a new potential source for cell therapy in type 1 diabetic patients, especially in light of recent successes in producing glucose-sensitive insulin secreting cells and this will be the scope of this study. In the last decade, human clinical trials of introducing insulin producing stem cells from various origins were approved and conducted.",[82,83],"Stem Cells","Type 1 Diabetes","2025-04-26",{"date":86,"type":87},"2025-04-30","ACTUAL",{"date":89,"type":87},"2025-04-01",{"date":91,"type":75},"2026-09-01",{"name":5,"class":6},1]