[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639013":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":43,"responsibleParty":62,"collaborators":25,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":25,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":25,"enrollmentInfo":74,"targetDuration":25,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":86,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Beni-Suef University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intravesical Aminophylline","EXPERIMENTAL","Participants will receive intravesical instillation of 250 mg aminophylline diluted with normal saline to a total volume of 160 mL. The solution will be retained in the bladder for 5 minutes before attempted urgent retrograde Double-J ureteral stent placement.",[13],"Drug: Intravesical Aminophylline",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Saline","PLACEBO_COMPARATOR","Participants will receive intravesical placebo instillation using normal saline to a total volume of 160 mL. The solution will be retained in the bladder for 5 minutes before attempted urgent retrograde Double-J ureteral stent placement.",[19],"Drug: Placebo Saline",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Aminophylline 250 mg diluted with normal saline to a total intravesical instillation volume of 160 mL. The solution will be retained in the bladder for 5 minutes before urgent retrograde Double-J ureteral stent placement.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Placebo intravesical instillation using normal saline to a total volume of 160 mL. The solution will be retained in the bladder for 5 minutes before urgent retrograde Double-J ureteral stent placement.",[15],[30],{"name":31,"affiliation":5,"role":32},"Hany F Badawy, MD","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"Hany F Badawy, Md","CONTACT","+201149525028","Hanyfathy86@gmail.com",{"name":40,"role":36,"phone":41,"phoneExt":25,"email":42},"Mahmoud Abdallah, MD","+201211874080","Drhanyfathy86@GMAIL.COM",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":25,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Department of Urology- Beni-Suef University Hospitals","RECRUITING","Banī Suwayf","Beni Suweif Governorate","Egypt","EG",{"type":52,"coordinates":53},"Point",[54,55],31.09785,29.07441,{"lat":55,"lon":54},[58,59,61],{"name":31,"role":36,"phone":37,"phoneExt":25,"email":38},{"name":60,"role":36,"phone":41,"phoneExt":25,"email":42},"Mahmoud Abdallah, Md",{"name":31,"role":32,"phone":25,"phoneExt":25,"email":25},{"type":32,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Hany Fathy Badawy, MD","Lecturer of Urology, Faculty of Medicine, Beni-Suef University","100639013","phase-2-intravesical-aminophylline-for-urgent-ureteral-stenting-in-acute-calculous-anuria-100639013",false,"NCT07617948","Intravesical Aminophylline for Urgent Ureteral Stenting in Acute Calculous Anuria","Intravesical Aminophylline-Assisted Urgent Retrograde Ureteral Stenting for Acute Calculous Anuria: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients aged 18 years or older.\n2. Diagnosis of acute calculous anuria due to ureteral stone obstruction in a solitary functioning kidney.\n3. Obstruction confirmed by pelvi-abdominal ultrasound and computed tomography of the urinary tract.\n4. Clinical and laboratory evidence of acute renal impairment, including oliguria or anuria and serum creatinine \\>2 mg\u002FdL.\n5. Ability to provide written informed consent.\n\nExclusion Criteria:\n\n1. Known hypersensitivity to aminophylline, theophylline, or other methylxanthines.\n2. Evidence of active urinary tract infection or urosepsis.\n3. Previous history of ureteral stricture or major urinary tract reconstructive surgery.\n4. Hemodynamic instability requiring immediate life-saving measures before urological intervention.\n5. Pregnancy.","ALL","18 Years",{"count":75,"type":76},72,"ESTIMATED","INTERVENTIONAL",[79],"PHASE2","Acute calculous anuria is a urological emergency caused by ureteral stone obstruction in a solitary functioning kidney or bilateral ureteral obstruction. Urgent decompression of the upper urinary tract is required to restore urine drainage and prevent further renal impairment.\n\nThis prospective randomized double-blind controlled trial will evaluate whether intravesical aminophylline can facilitate urgent retrograde ureteral stenting in adult patients with acute calculous anuria due to ureteral stones. Eligible patients will be randomly assigned to receive either intravesical aminophylline diluted in normal saline or placebo saline before attempted retrograde Double-J ureteral stent placement.\n\nThe primary outcome is technical success, defined as successful placement of a Double-J ureteral stent across the obstructing stone without the need for percutaneous nephrostomy. Secondary outcomes include stenting time, intraoperative complications, renal function recovery, postoperative pain, analgesic requirement, and the need for alternative drainage.",[82,83,84,85],"Acute Calculous Anuria","Ureteral Calculi","Obstructive Uropathy","Acute Kidney Injury",[87,88,89,90,91],"Intravesical aminophylline","Retrograde ureteral stenting","Acute calculous anuria","Emergency urinary drainage","Double-J stent","2026-05-29",{"date":94,"type":95},"2026-06-02","ACTUAL",{"date":97,"type":95},"2026-04-08",{"date":99,"type":76},"2027-04",{"name":5,"class":6},1]