[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100585803":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":29,"locations":39,"responsibleParty":57,"collaborators":59,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":24,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":24,"studyType":76,"phases":77,"briefSummary":80,"conditions":81,"keywords":24,"overallStatus":84,"whyStopped":24,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Integrant Pty Ltd","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment of Ankle Arthritis","EXPERIMENTAL","Injection of 10 iu of Somatropin and Platelet-Rich Plasma conjunct via intra-articular injection of the arthritic ankle. This will be administered with a 7-16 day buffer period between each injection. There will be three total injections for the study.",[13],"Drug: Intra-Articular Injection of Growth Hormone and Platelet-Rich Plasma",{"label":15,"type":10,"description":16,"interventionNames":17},"Treatment of Knee Arthritis","Injection of 10 iu of Somatropin and Platelet-Rich Plasma conjunct via intra-articular injection of the arthritic knee. This will be administered with a 7-16 day buffer period between each injection. There will be three total injections for the study.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Intra-Articular Injection of Growth Hormone and Platelet-Rich Plasma","Intervention will be an intra-articular injection of 10 units of HGH and 10 mL PRP conjunct. Three total injections\u002Fplacements of HGH spaced 7 to 16 days apart on either the effected ankle or knee joint guided by ultrasound.",[9,15],null,[26],{"name":27,"affiliation":5,"role":28},"Gordon L Slater, Professor","PRINCIPAL_INVESTIGATOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Gordon L Slater, Prof","CONTACT","+61 418 721 380","gordonjakll@gmail.com",{"name":36,"role":32,"phone":37,"phoneExt":24,"email":38},"Zadane F Bachmid","+61 426 672 977","zadane@integrant.com.au",[40],{"facility":41,"status":24,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Dr Gordon Slater: Orthopaedic Surgeon","Potts Point","New South Wales","2011","Australia","AU",{"type":48,"coordinates":49},"Point",[50,51],151.22586,-33.86701,{"lat":51,"lon":50},[54,56],{"name":36,"role":32,"phone":55,"phoneExt":24,"email":38},"+61 7232 1156",{"name":27,"role":28,"phone":24,"phoneExt":24,"email":24},{"type":58,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[60],{"name":61,"class":62},"University of Technology, Sydney","OTHER","100585803","phase-2-investigation-of-growth-hormone-and-platelet-rich-plasma-on-joint-health-100585803",false,"NCT06907121","Investigation of Growth Hormone and Platelet-Rich Plasma on Joint Health","Investigation of Intra-Articular Growth Hormone and Platelet-Rich Plasma on Joint Health in Adults With Knee and Ankle Arthritis Resistant to Treatment","Inclusion Criteria:\n\n* Ankle\u002FKnee arthritis resistant to treatment in GP clinic setting.\n* Significant Ankle\u002FKnee cartilage injury can be shown on MRI scan or weight bearing X-Ray within 6 months of study application.\n* Able to give informed consent to participation in a clinical trial.\n* Able to commit to attending clinic for follow up.\n\nExclusion Criteria:\n\n* A known hypersensitivity to any of the components of the product.\n* Cancer diagnosis or suspicion.\n* Resected or active tumor.\n* Skeletally immature (\\\u003C18 years of age or no radiographic evidence of closure of epiphyses).\n* Pregnancy.\n* Active infection at the injection site.\n* Open soft tissue injury.\n* Metabolic disorders known to adversely affect the skeleton (e.g. renal osteodystrophy or hypercalcemia), other than primary osteoporosis or diabetes.\n* Over 70 years of age\n* Unstable joint or maligned joint \\> 5%\n* No cartilage detected in the joint (bone on bone in medical imaging)\n* Unable to give informed consent.\n* Unable to commit to attend clinic for follow up.","ALL","18 Years","70 Years",{"count":74,"type":75},60,"ESTIMATED","INTERVENTIONAL",[78,79],"PHASE2","PHASE3","This clinical study will evaluate the efficacy of intra-articular (IA) injection of growth hormone (HGH) and platelet-rich plasma (PRP) in adults with knee and ankle arthritis resistant to conventional treatment.\n\nThe study, sponsored by Integrant Pty Ltd and led by Prof. Gordon Slater, aims to determine whether IA HGH injections can enhance cartilage regeneration and joint healing.\n\nThe study will recruit 60 patients who will receive three IA injections of HGH and PRP spaced 7-16 days of each other.\n\nOutcomes will be assessed using AOFAS and AKS scoring systems at 3- and 6-months post-treatment.\n\nThe study hypothesizes that HGH will increase healing of arthritic or injured joints compared to standard treatment, potentially providing a non-surgical alternative for patients with treatment-resistant arthritis.",[82,83],"Arthritis Ankle","Arthritis Knee","NOT_YET_RECRUITING","2025-03-26",{"date":87,"type":88},"2025-04-02","ACTUAL",{"date":90,"type":75},"2025-06-01",{"date":92,"type":75},"2027-12-01",{"name":5,"class":6},1]