[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596427":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":28,"locations":34,"responsibleParty":356,"collaborators":11,"id":358,"slug":359,"hasResults":360,"nctId":361,"briefTitle":362,"officialTitle":363,"acronym":11,"eligibilityCriteria":364,"healthyVolunteers":360,"sex":365,"minAge":366,"maxAge":367,"enrollmentInfo":368,"targetDuration":11,"studyType":371,"phases":372,"briefSummary":374,"conditions":375,"keywords":11,"overallStatus":58,"whyStopped":11,"lastUpdateSubmitDate":377,"lastUpdatePostDateStruct":378,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":385,"locationsCount":386},{"fullName":5,"class":6},"Shanghai Junshi Bioscience Co., Ltd.","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cohort A","EXPERIMENTAL",null,[13],"Drug: JS207 in combination with 9MW2821",{"label":15,"type":10,"description":11,"interventionNames":16},"Cohort B",[17],"Drug: JS207 in combination with Albumin paclitaxel",[19,24],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"DRUG","JS207 in combination with 9MW2821","JS207 will be administered intravenously at a dose of 10 mg\u002Fkg (D1, Q3W), 9MW2821 will be administered intravenously at a dose of 1.25 m.g\u002Fkg (D1 and D8, Q3W)",[9],{"type":20,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"JS207 in combination with Albumin paclitaxel","JS207 will be administered intravenously at a dose of 10 mg\u002Fkg (D1, Q3W), Albumin paclitaxel will be administered intravenously at a dose of 125 mg\u002Fm2 (D1 and D8, Q3W).",[15],[29],{"name":30,"role":31,"phone":32,"phoneExt":11,"email":33},"Chaoqiang Yang, Master","CONTACT","18252095266","chaoqiang_yang@junshipharma.com",[35,56,71,83,99,116,132,142,153,169,185,197,213,229,245,260,272,288,304,315,324,340],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Anhui Provincial Cancer Hospital","NOT_YET_RECRUITING","Hefei","Anhui","230000","China","CN",{"type":44,"coordinates":45},"Point",[46,47],117.28083,31.86389,{"lat":47,"lon":46},[50,54],{"name":51,"role":31,"phone":52,"phoneExt":11,"email":53},"Yueyin Pan, Doctor","13805695536","yueyinpan1965@126.com",{"name":51,"role":55,"phone":11,"phoneExt":11,"email":11},"PRINCIPAL_INVESTIGATOR",{"facility":57,"status":58,"city":59,"state":60,"zip":61,"country":41,"countryCode":42,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Peking University People's Hospital","RECRUITING","Beijing","Beijing Municipality","100044",{"type":44,"coordinates":63},[64,65],116.39723,39.9075,{"lat":65,"lon":64},[68,70],{"name":69,"role":31,"phone":11,"phoneExt":11,"email":11},"Shu Wang, Doctor",{"name":69,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":72,"status":58,"city":59,"state":60,"zip":73,"country":41,"countryCode":42,"cosmosGeoPoint":74,"geoPoint":76,"contacts":77},"The Fifth Medical Center of PLA General Hospital","100071",{"type":44,"coordinates":75},[64,65],{"lat":65,"lon":64},[78,82],{"name":79,"role":31,"phone":80,"phoneExt":11,"email":81},"Zefei Jiang, Doctor","13901372170","jzf_cscobc@csco.org.cn",{"name":79,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":84,"status":37,"city":85,"state":86,"zip":87,"country":41,"countryCode":42,"cosmosGeoPoint":88,"geoPoint":92,"contacts":93},"Guangdong women and children's hospital and health institute","Guangzhou","Guangdong","511400",{"type":44,"coordinates":89},[90,91],113.25,23.11667,{"lat":91,"lon":90},[94,98],{"name":95,"role":31,"phone":96,"phoneExt":11,"email":97},"Anqin Zhang, Doctor","13925115929","30542933@qq.com",{"name":95,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":100,"status":58,"city":101,"state":102,"zip":103,"country":41,"countryCode":42,"cosmosGeoPoint":104,"geoPoint":108,"contacts":109},"Affiliated Hospital of Hebei University","Baoding","Hebei","071030",{"type":44,"coordinates":105},[106,107],115.46246,38.87288,{"lat":107,"lon":106},[110,114],{"name":111,"role":31,"phone":112,"phoneExt":11,"email":113},"Hua Yang, Doctor","18603120729","docgh@163.com",{"name":115,"role":55,"phone":11,"phoneExt":11,"email":11},"Hua Yang",{"facility":117,"status":37,"city":118,"state":119,"zip":120,"country":41,"countryCode":42,"cosmosGeoPoint":121,"geoPoint":125,"contacts":126},"Harbin Medical University Affiliated Cancer Hospital","Harbin","Heilongjiang","150001",{"type":44,"coordinates":122},[123,124],126.65,45.75,{"lat":124,"lon":123},[127,131],{"name":128,"role":31,"phone":129,"phoneExt":11,"email":130},"Tong Liu, Doctor","15945953777","liutong@hrbmu.edu.cn",{"name":128,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":117,"status":37,"city":118,"state":119,"zip":120,"country":41,"countryCode":42,"cosmosGeoPoint":133,"geoPoint":135,"contacts":136},{"type":44,"coordinates":134},[123,124],{"lat":124,"lon":123},[137,141],{"name":138,"role":31,"phone":139,"phoneExt":11,"email":140},"Li Cai, Doctor","13313602929","caiwenxin76@163.com",{"name":138,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":143,"status":58,"city":144,"state":145,"zip":146,"country":41,"countryCode":42,"cosmosGeoPoint":11,"geoPoint":11,"contacts":147},"Henan Cancer Hospital","Zhangzhou","Henan","450003",[148,152],{"name":149,"role":31,"phone":150,"phoneExt":11,"email":151},"Min Yan, Doctor","15713857388","ym200678@126.com",{"name":149,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":154,"status":58,"city":155,"state":156,"zip":157,"country":41,"countryCode":42,"cosmosGeoPoint":158,"geoPoint":162,"contacts":163},"Hubei Cancer Hospital","Wuhan","Hubei","430079",{"type":44,"coordinates":159},[160,161],114.26667,30.58333,{"lat":161,"lon":160},[164,168],{"name":165,"role":31,"phone":166,"phoneExt":11,"email":167},"Xinhong Wu, Doctor","18602726300","xinhongwuhbch@163.com",{"name":165,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":170,"status":58,"city":171,"state":172,"zip":173,"country":41,"countryCode":42,"cosmosGeoPoint":174,"geoPoint":178,"contacts":179},"Jiangsu Cancer Hospital","Nanjing","Jiangsu","210009",{"type":44,"coordinates":175},[176,177],118.77778,32.06167,{"lat":177,"lon":176},[180,184],{"name":181,"role":31,"phone":182,"phoneExt":11,"email":183},"Sainan Hu, Doctor","13770770678","hsndot@sina.com",{"name":181,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":186,"status":37,"city":171,"state":172,"zip":187,"country":41,"countryCode":42,"cosmosGeoPoint":188,"geoPoint":190,"contacts":191},"Jiangsu Province Hospital","210029",{"type":44,"coordinates":189},[176,177],{"lat":177,"lon":176},[192,196],{"name":193,"role":31,"phone":194,"phoneExt":11,"email":195},"Yongmei Yin, Doctor","13951842727","ym.yin@hotmail.com",{"name":193,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":198,"status":37,"city":199,"state":200,"zip":201,"country":41,"countryCode":42,"cosmosGeoPoint":202,"geoPoint":206,"contacts":207},"Nanchang People'S Hospital","Nanchang","Jiangxi","330000",{"type":44,"coordinates":203},[204,205],115.85306,28.68396,{"lat":205,"lon":204},[208,212],{"name":209,"role":31,"phone":210,"phoneExt":11,"email":211},"Wenyan Chen, Doctor","18679168977","chenwenyannc2013@163.com",{"name":209,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":214,"status":58,"city":215,"state":216,"zip":217,"country":41,"countryCode":42,"cosmosGeoPoint":218,"geoPoint":222,"contacts":223},"Jilin University First Hospital","Changchun","Jilin","130021",{"type":44,"coordinates":219},[220,221],125.32278,43.88,{"lat":221,"lon":220},[224,228],{"name":225,"role":31,"phone":226,"phoneExt":11,"email":227},"Zheng Lv, Doctor","15804301705","2886154@qq.com",{"name":225,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":230,"status":58,"city":231,"state":232,"zip":233,"country":41,"countryCode":42,"cosmosGeoPoint":234,"geoPoint":238,"contacts":239},"The Second Hospital of Dalian Medical University","Dalian","Liaoning","116027",{"type":44,"coordinates":235},[236,237],121.60222,38.91222,{"lat":237,"lon":236},[240,244],{"name":241,"role":31,"phone":242,"phoneExt":11,"email":243},"Man Li, Doctor","17709873580","dyeyliman@sohu.com",{"name":241,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":246,"status":58,"city":247,"state":232,"zip":248,"country":41,"countryCode":42,"cosmosGeoPoint":249,"geoPoint":253,"contacts":254},"The First Hospital of China Medical University","Shenyang","110002",{"type":44,"coordinates":250},[251,252],123.43278,41.79222,{"lat":252,"lon":251},[255,259],{"name":256,"role":31,"phone":257,"phoneExt":11,"email":258},"Yuee Teng, Doctor","13591639797","tengyuee0517@163.com",{"name":256,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":261,"status":58,"city":247,"state":232,"zip":262,"country":41,"countryCode":42,"cosmosGeoPoint":263,"geoPoint":265,"contacts":266},"Liaoning Cancer Hospital&Institute","110801",{"type":44,"coordinates":264},[251,252],{"lat":252,"lon":251},[267,271],{"name":268,"role":31,"phone":269,"phoneExt":11,"email":270},"Tao Sun, Doctor","13940404526","jianong@126.com",{"name":268,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":273,"status":37,"city":274,"state":275,"zip":276,"country":41,"countryCode":42,"cosmosGeoPoint":277,"geoPoint":281,"contacts":282},"Ceneral Hosipital of Ningxia Medical University","Yinchuan","Ningxia","750000",{"type":44,"coordinates":278},[279,280],106.27306,38.46806,{"lat":280,"lon":279},[283,287],{"name":284,"role":31,"phone":285,"phoneExt":11,"email":286},"Ye LV, Master","18709515757","liuweilvye@yeah.net",{"name":284,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":289,"status":58,"city":290,"state":291,"zip":292,"country":41,"countryCode":42,"cosmosGeoPoint":293,"geoPoint":297,"contacts":298},"The Affiliated Hospital of Qingdao University","Qingdao","Shandong","266035",{"type":44,"coordinates":294},[295,296],120.38042,36.06488,{"lat":296,"lon":295},[299,303],{"name":300,"role":31,"phone":301,"phoneExt":11,"email":302},"Haibo Wang, Doctor","18661805787","hbwang66@126.com",{"name":300,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":305,"status":58,"city":306,"state":307,"zip":308,"country":41,"countryCode":42,"cosmosGeoPoint":11,"geoPoint":11,"contacts":309},"The First Affiliated Hospital of Xi'an Jiaotong University","Xian","Shanxi","710061",[310,314],{"name":311,"role":31,"phone":312,"phoneExt":11,"email":313},"Jin Yang, Doctor","18991232383","1473106133@qq.com",{"name":311,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":316,"status":58,"city":306,"state":307,"zip":317,"country":41,"countryCode":42,"cosmosGeoPoint":11,"geoPoint":11,"contacts":318},"Xi'an International Medical Center Hospital","710100",[319,323],{"name":320,"role":31,"phone":321,"phoneExt":11,"email":322},"Yan Xue, Doctor","13992830596","xueyan000516@163.com",{"name":320,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":325,"status":58,"city":326,"state":327,"zip":328,"country":41,"countryCode":42,"cosmosGeoPoint":329,"geoPoint":333,"contacts":334},"Affiliated Tumor Hospital of Xinjiang Medical University","Ürümqi","Xinjiang Uygur Autonomous Region","830000",{"type":44,"coordinates":330},[331,332],87.60046,43.80096,{"lat":332,"lon":331},[335,339],{"name":336,"role":31,"phone":337,"phoneExt":11,"email":338},"Bing Zhao, Doctor","13899908184","819502412@qq.com",{"name":336,"role":55,"phone":11,"phoneExt":11,"email":11},{"facility":341,"status":37,"city":342,"state":343,"zip":344,"country":41,"countryCode":42,"cosmosGeoPoint":345,"geoPoint":349,"contacts":350},"The Second Affiliated Hospital Zhejiang University School of Medicine","Hangzhou","Zhejiang","310000",{"type":44,"coordinates":346},[347,348],120.16142,30.29365,{"lat":348,"lon":347},[351,355],{"name":352,"role":31,"phone":353,"phoneExt":11,"email":354},"Yiding Chen, Doctor","13605719519","ydchen@zju.edu.cn",{"name":352,"role":55,"phone":11,"phoneExt":11,"email":11},{"type":357,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100596427","phase-2-js207-combination-therapy-in-triple-negative-breast-cancer-100596427",false,"NCT07045311","JS207 Combination Therapy in Triple-negative Breast Cancer","JS207 Combination Therapy in Recurrent or Metastatic Triple-negative Breast Cancer(TNBC)","Inclusion Criteria:\n\n1. Male or female age 18 - 75 years old；\n2. Voluntary participation in clinical study；\n3. Histologically confirmed unresectable, locally advanced or metastatic triple-negative breast cancer(absence of HER2, ER, and PR expression);\n4. No prior systemic antitumor therapy for locally advanced or Metastatic TNBC；\n5. Prior use of systemic anti-tumor therapy in the neoadjuvant and\u002For adjuvant phase is allowed, but must meet the following conditions: (1) the time interval between the end of neoadjuvant\u002Fadjuvant therapy and the occurrence of recurrence\u002Fmetastasis is ≥6 months; (2) Arm2: if taxane is used in the neoadjuvant\u002Fadjuvant phase, the DFI must be ≥12 months;\n6. Adequate organ function;\n7. ECOG performance status of 0 or 1;\n8. Life expectancy 12 weeks;\n9. Measurable disease, as defined by RECIST v1.1;\n\nExclusion Criteria:\n\n1. Untreated or active central nervous system (CNS) metastases；\n2. Uncontrolled pleural effusion, pericardial effusion or ascites；\n3. Tumor encasement of important vessels or significant necrosis and cavitation that may cause a risk of hemorrhage；\n4. History of significant bleeding tendency or severe coagulation disorder；\n5. Uncontrolled hypertension；\n6. Active autoimmune diseases requiring systemic treatmen within 2 years prior to the first dose；\n7. History of interstitial lung disease or previous Noninfectious pneumonitis treated with corticosteroids, or evidence of active Pneumonia in radiology on screening period；\n8. Eye disorders or symptoms: severe xerophthalmia, keratoconjunctivitis sicca, severe exposure keratitis, or other conditions；\n9. Severe cardiovascular disease；\n10. Serious infection (CTCAE 5.0 Grade\\>2) within 28 days prior to the first dose of study drug；\n11. Previous treatment with anti-PD-1, anti-PD-L1 or anti-PD-L2 drugs or drugs targeting other stimulatory or co-inhibitory T cell receptors (e.g., CTLA-4, OX-40, CD137) in (new) adjuvant therapy is allowed, if DFI is ≥6 months previously treated with Antibody-Drug Conjugates conjugated with MMAE and\u002For targeting Nectin-4, such as Enfortumab Vedotin is not allowed；\n12. History of another malignancy within 5 years before the first dose of study drug；\n13. Not suitable to receive study treatment for other conditions as per investigator；","ALL","18 Years","75 Years",{"count":369,"type":370},80,"ESTIMATED","INTERVENTIONAL",[373],"PHASE2","This is an open-label, multi-center, phase II clinical study to preliminarily evaluate the efficacy and safety of JS207 combined with 9MW2821 or albumin paclitaxel as first-line therapy in patients with recurrent or metastatic TNBC.",[376],"Triple-negative Breast Cancer","2026-04-10",{"date":379,"type":380},"2026-04-15","ACTUAL",{"date":382,"type":380},"2025-09-17",{"date":384,"type":370},"2029-03-22",{"name":5,"class":6},22]