[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590562":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":40,"centralContacts":45,"locations":55,"responsibleParty":77,"collaborators":27,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":27,"eligibilityCriteria":85,"healthyVolunteers":81,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":27,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":27,"overallStatus":58,"whyStopped":27,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Shanghai Junshi Bioscience Co., Ltd.","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"JS207+ Pemetrexed + a platinum","EXPERIMENTAL","Enrolling 30-42 Non-squamous non-small cell lung cancerparticipants，Patients will receive JS207 (10 mg\u002Fkg or 15 mg\u002Fkg, IV, D1) + Pemetrexed (500 mg\u002Fm2 IV, D1) + a platinum (carboplatin AUC 5, D1 or cisplatin 75 mg\u002Fm2, D1), Q3W, for 4 cycles followed by JS207 (10 mg\u002Fkg or 15 mg\u002Fkg, IV, D1) + pemetrexed (500 mg\u002Fm2 IV, D1), Q3W.",[13,14,15],"Drug: JS207","Drug: Pemetrexed injection","Drug: Platinum",{"label":17,"type":10,"description":18,"interventionNames":19},"JS207+ Paclitaxel + a platinum","Enrolling 30-42 squamous non-small cell lung cancerparticipants，Patients will receive JS207 (10 mg\u002Fkg or 15 mg\u002Fkg, IV, D1) + Paclitaxel (175 mg\u002Fm2 IV, D1) + a platinum (carboplatin AUC 5, D1 or cisplatin 75 mg\u002Fm2, D1), Q3W, for 4 cycles followed by JS207 (10 mg\u002Fkg or 15 mg\u002Fkg, IV, D1), Q3W.",[13,15,20],"Drug: Paclitaxel",[22,28,32,36],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DRUG","JS207","JS207 (10 mg\u002Fkg or 15 mg\u002Fkg, IV, d1)",[17,9],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"Pemetrexed injection","Pemetrexed (500 mg\u002Fm2 IV, D1)",[9],{"type":23,"name":33,"description":34,"armGroupLabels":35,"otherNames":27},"Platinum","Platinum (carboplatin AUC 5, D1 or cisplatin 75 mg\u002Fm2, D1)",[17,9],{"type":23,"name":37,"description":38,"armGroupLabels":39,"otherNames":27},"Paclitaxel","Paclitaxel (175 mg\u002Fm2 IV, D1)",[17],[41],{"name":42,"affiliation":43,"role":44},"Weihua Wang, Doctor","Medical Director","STUDY_DIRECTOR",[46,51],{"name":47,"role":48,"phone":49,"phoneExt":27,"email":50},"Ying Zhang, Master","CONTACT","18616904609","ying_zhang2@junshipharma.com",{"name":52,"role":48,"phone":53,"phoneExt":27,"email":54},"Huiyu Lan, Master","15000239047","huiyu_lan@junshipharma.com",[56],{"facility":57,"status":58,"city":59,"state":60,"zip":61,"country":62,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"Shandong First Medical University Affiliated Neoplasm Hospital","RECRUITING","Jinan","Shandong","250117","China","CN",{"type":65,"coordinates":66},"Point",[67,68],116.99722,36.66833,{"lat":68,"lon":67},[71,75],{"name":72,"role":48,"phone":73,"phoneExt":27,"email":74},"Jinming Yu, Ph.D","13806406293","sdyujinming@126.com",{"name":72,"role":76,"phone":27,"phoneExt":27,"email":27},"PRINCIPAL_INVESTIGATOR",{"type":78,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR","100590562","phase-2-js207combined-with-chemotherapy-in-first-line-treatment-of-advanced-nsclc-100590562",false,"NCT06969027","JS207Combined With Chemotherapy in First-line Treatment of Advanced NSCLC","JS207 (PD-1\u002FVEGF Dual Antibody) Combined With Chemotherapy in First-line Treatment of Advanced Non-small Cell Lung Cancer","Inclusion Criteria:\n\n1. Age between 18 and 75 years old (both 18 and 75 years old included) at the time of signing the informed consent form, applicable to both males and females.\n2. Locally advanced (stage IIIB\u002FIIIC), metastatic or recurrent non-small cell lung cancer (NSCLC) confirmed by histology or cytology, which is not eligible for radical surgery or radical chemoradiotherapy.\n3. History of no systemic antitumor therapy for Metastatic or recurrent NSCLC; for subjects who have received adjuvant\u002Fneoadjuvant\u002Fconsolidation therapy (Chemotherapy, radiotherapy, or other therapy), they can be enrolled if the interval between the last treatment and recurrence is more than 6 months.\n4. Tissue samples are required for PD-L1 test. New tissue samples are preferred. If new tissue samples are not available, archived samples can be provided.\n5. According to the RECIST v1.1 criteria, the subject has at least 1 measurable lesion.\n6. Performance status score of 0-1 according to the Eastern Cooperative Oncology Group (ECOG) scale.\n7. Expected survival period ≥ 12 weeks.\n8. The function of important organs meets the requirements of the protocol.\n9. Female subjects of childbearing potential, and male subjects whose partners are females of childbearing age, need to adopt a highly effective contraceptive measure during the study treatment period and for at least 6 months after the last administration.\n10. Voluntarily joining this study, signing the informed consent form, having good compliance, and cooperating with the follow-up.\n\nExclusion Criteria:\n\n1. Histopathologically or cytopathologically confirmed to have combined neuroendocrine (including small cell lung cancer and large cell neuroendocrine carcinoma) components.\n2. Treatment received as listed in the protocol, including immunologically mediated treatment; drugs targeting the anti-VEGF pathway, etc.\n3. Having an obvious bleeding tendency or a history of severe coagulation dysfunction.\n4. Gastrointestinal perforation, intra-abdominal fistula or intra-abdominal abscess occurred within 6 months before the first administration, or currently having high-risk factors for perforation\u002Ffistula formation of the hollow viscus as judged by the investigator.\n5. Having a serious, unhealed or ruptured wound, active ulcer or untreated fracture.\n6. Having uncontrolled hypertension, or a history of hypertensive crisis or hypertensive encephalopathy.\n7. Expected that the toxicity of previous anti-tumor treatment has not recovered to ≤ grade 1 according to the Common Terminology Criteria for Adverse Events (CTCAE).\n8. Known allergy to the investigational drug or its excipients, pemetrexed, platinum drugs (carboplatin\u002Fcisplatin), or known history of ≥ grade 3 allergy to antibody drugs","ALL","18 Years","75 Years",{"count":90,"type":91},84,"ESTIMATED","INTERVENTIONAL",[94],"PHASE2","This study targets patients with in first-line treatment of advanced NSCLC， enrolling 60-84 participants. Patients will receive Arm 1: JS207 (10 mg\u002Fkg or 15 mg\u002Fkg, IV, D1) + Pemetrexed (500 mg\u002Fm2 IV, D1) + a platinum (carboplatin AUC 5, D1 or cisplatin 75 mg\u002Fm2, D1), Q3W, for 4 cycles followed by JS207 (10 mg\u002Fkg or 15 mg\u002Fkg, IV, D1) + pemetrexed (500 mg\u002Fm2 IV, D1), Q3W, until meeting the treatment withdrawal criteria. Arm 2: JS207 (10 mg\u002Fkg or 15 mg\u002Fkg, IV, D1) + Paclitaxel (175 mg\u002Fm2 IV, D1) + a platinum (carboplatin AUC 5, D1 or cisplatin 75 mg\u002Fm2, D1), Q3W, for 4 cycles followed by JS207 (10 mg\u002Fkg or 15 mg\u002Fkg, IV, D1), Q3W, until meeting the treatment withdrawal criteria.The study aims to assess the safety, tolerability, and preliminary efficacy of JS207 combination therapy.",[97],"Non-small Cell Lung Cancer","2025-07-02",{"date":100,"type":101},"2025-07-04","ACTUAL",{"date":103,"type":101},"2025-06-19",{"date":105,"type":91},"2027-12-31",{"name":5,"class":6},1]