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physically and mentally fit for radical\u002Fhigh dose palliative radiotherapy\n* Target tumour accessible for intra-tumoural injection\n* Patient suitable\u002Fcompliant with MR protocol\n* At least one tumour diameter ≥30 mm and ≤150 mm measurable by ultrasound or MR imaging\n* Patients with predicted life expectancy of 12 months or more\n* Negative pregnancy test before start of radiotherapy in women of child bearing potential and an ability\u002Fwillingness to protect against pregnancy from consent and for 3 months post-radiotherapy\n* Patient offers written informed consent\n\nExclusion Criteria:\n\n* Prior radiotherapy to the target area\n* Maximum diameter of target tumour \\\u003C30 mm or \\>150mm measurable by ultrasound or MR\n* Anatomical location and\u002For extent of disease difficult to access for safe intra-tumoural drug injections, for example by virtue of contiguous major blood vessels and\u002For brachial plexus\n* Concomitant chemotherapy or biological therapy except Herceptin, Pertuzumab and Denosumab (all endocrine therapies and bisphosphonates are allowed concomitantly; other cytotoxics and biological therapies apart from those mentioned above should be stopped 3 weeks prior to RT)\n* Pregnancy or nursing\n* Hypersensitivity to any of the KORTUC ingredients","ALL","18 Years",{"count":237,"type":238},184,"ESTIMATED","INTERVENTIONAL",[241],"PHASE2","This is a study aimed at testing a commonly available and inexpensive chemical (hydrogen peroxide) for efficacy in sensitising large cancerous lumps in the breast to a standard course of radiotherapy in patients with locally advanced or recurrent breast cancer. 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