[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637394":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":67,"collaborators":26,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":26,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":26,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Beni-Suef University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"L-Citrulline Plus Tamsulosin Placebo","EXPERIMENTAL","Participants will receive oral L-citrulline 750 mg twice daily plus a matched tamsulosin placebo once daily. Treatment will continue until documented stone passage or completion of 4 weeks of therapy, whichever occurs first. Standard supportive care will be provided as needed.",[13],"Drug: L-Citrulline",{"label":15,"type":16,"description":17,"interventionNames":18},"Tamsulosin Plus L-Citrulline Placebo","ACTIVE_COMPARATOR","Participants will receive oral tamsulosin 0.4 mg once daily plus a matched L-citrulline placebo twice daily. Treatment will continue until documented stone passage or completion of 4 weeks of therapy, whichever occurs first. Standard supportive care will be provided as needed.",[19],"Drug: Tamsulosin",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","L-Citrulline","Oral L-citrulline 750 mg twice daily will be administered until documented stone passage or completion of 4 weeks of therapy, whichever occurs first.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Tamsulosin","Oral tamsulosin 0.4 mg once daily will be administered until documented stone passage or completion of 4 weeks of therapy, whichever occurs first.",[15],[32],{"name":33,"affiliation":34,"role":35},"Hany F Badawy, MD","Faculty of Medicine, Beni-Suef University","PRINCIPAL_INVESTIGATOR",[37,41],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","+201149525028","Hanyfathy86@gmail.com",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Ahmed Gmal, MD","+20 11 18206022","Drhanyfathy86@GMAIL.COM",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Department of Urology- Beni-Suef University Hospitals","RECRUITING","Banī Suwayf","Beni Suweif Governorate","02456","Egypt","EG",{"type":55,"coordinates":56},"Point",[57,58],31.09785,29.07441,{"lat":58,"lon":57},[61,62,66],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},{"name":63,"role":38,"phone":64,"phoneExt":26,"email":65},"Mahmoud Abdallah, Md","+20 11 55361979","Mahmoud.abdalla@med.bsu.edu.eg",{"name":33,"role":35,"phone":26,"phoneExt":26,"email":26},{"type":35,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Hany Fathy Badawy, MD","Lecturer of Urology, Faculty of Medicine, Beni-Suef University","100637394","phase-2-l-citrulline-versus-tamsulosin-for-medical-expulsive-therapy-of-distal-ureteral-stones-100637394",false,"NCT07617909","L-Citrulline Versus Tamsulosin for Medical Expulsive Therapy of Distal Ureteral Stones","L-Citrulline Versus Tamsulosin for Medical Expulsive Therapy of Distal Ureteral Stones: A Prospective Randomized Study","Inclusion Criteria:\n\n* Adults aged 18 to 60 years.\n* Single distal ureteral stone.\n* Stone size 5 to 10 mm.\n* Normal renal function.\n* Controlled pain.\n* Willingness to comply with follow-up for 4 weeks.\n* Written informed consent.\n\nExclusion Criteria:\n\n* Fever or active urinary tract infection.\n* Severe hydronephrosis.\n* Solitary kidney.\n* Pregnancy.\n* Previous ureteric surgery.\n* Multiple ureteral stones.\n* Indication for urgent surgical intervention.\n* Known hypersensitivity or contraindication to L-citrulline or tamsulosin.\n* Inability to complete follow-up.","ALL","18 Years","60 Years",{"count":81,"type":82},120,"ESTIMATED","INTERVENTIONAL",[85],"PHASE2","This study will compare L-citrulline and tamsulosin as medical expulsive therapy for adults with single distal ureteral stones.\n\nEligible participants with a single distal ureteral stone measuring 5 to 10 mm will be randomly assigned to receive either oral L-citrulline 750 mg twice daily or oral tamsulosin 0.4 mg once daily. Treatment will continue until documented stone passage or completion of 4 weeks of therapy, whichever occurs first.\n\nParticipants will be followed weekly for up to 4 weeks. The main outcome is stone expulsion within 4 weeks. The study will also assess time to stone expulsion, pain episodes, analgesic use, need for additional intervention, and adverse events.",[88,89,90],"Distal Ureteral Stone","Urolithiasis","Ureteral Calculi",[23,92,93,28],"Medical Expulsive Therapy","Ureteral Stone Passage","2026-05-25",{"date":96,"type":97},"2026-06-01","ACTUAL",{"date":99,"type":97},"2026-05-06",{"date":101,"type":82},"2026-11",{"name":5,"class":6},1]