[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620740":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":38,"locations":39,"responsibleParty":56,"collaborators":38,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":62,"sex":68,"minAge":69,"maxAge":38,"enrollmentInfo":70,"targetDuration":38,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":85,"whyStopped":38,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"The Cooper Health System","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment","EXPERIMENTAL","Intra-arterial lidocaine",[13],"Drug: Lidocaine (drug)",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham","SHAM_COMPARATOR","Intra-arterial saline",[19],"Drug: Saline",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Lidocaine (drug)","Intra-arterial lidocaine infusion into bilateral middle meningeal arteries",[9],[27],"Xylocaine",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Saline","Intra-arterial saline infusion into bilateral middle meningeal arteries",[15],[33],"Fluids",[35],{"name":36,"affiliation":5,"role":37},"Manisha Koneru, MD","STUDY_CHAIR",null,[40],{"facility":41,"status":38,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Cooper University Health Care","Camden","New Jersey","08103","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-75.11962,39.92595,{"lat":51,"lon":50},[54],{"name":41,"role":55,"phone":38,"phoneExt":38,"email":38},"CONTACT",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":38,"oldOrganization":38},"SPONSOR_INVESTIGATOR","Daniel A Tonetti, MD","Assistant Professor of Neurological Surgery","100620740","phase-2-localized-injection-of-lidocaine-via-the-middle-meningeal-artery-for-intractable-headache-treatment-100620740",false,"NCT07361549","Localized Injection of Lidocaine Via the Middle Meningeal Artery for Intractable Headache Treatment","Localized Injection of Lidocaine Via the Middle Meningeal Artery for Intractable Headache Treatment: A Randomized, Double-Blinded, Parallel Phase 2 Clinical Trial","LIGHT 2","Inclusion Criteria:\n\n* Age 18 years or above\n* Referred for diagnostic angiography\n* Diagnosis of intractable migraine\n* Written informed consent able to be obtained from subject\n\nExclusion Criteria:\n\n* Baseline HIT-6 score less than 60 (severe)\n* Pregnant, breastfeeding, or unwilling to practice contraception during participation in the study\n* Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data\n* Concomitant intracranial pathology (eg, intracranial malignancy)\n* Known hypersensitivity and\u002For contraindication to lidocaine or local anesthetics of the amide type\n* Taking chronic medications that, when co-administered with lidocaine and other local anesthetics, are at increased risk of developing methemoglobinemia (nitrates\u002Fnitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, acetaminophen, metoclopramide, quinine, sulfasalazine)\n* Known contraindications for angiography (eg, ESRD not requiring hemodialysis). Patients with contrast allergy with be premeditated with diphenhydramine and steroids.\n* Contraindication to anesthetic agents used for conscious sedation\u002Fmonitored anesthesia care (MAC)\n* Concurrent participation in another research protocol for investigation of an experimental therapy\n* Per DSA imaging, presence of a cerebrovascular pathology known to cause headache (eg, arteriovenous malformation, dural arteriovenous fistula)\n* Per DSA imaging, presence of anastomosis or anatomical variation (eg, branches of middle meningeal artery) that could lead to increased procedural risk\n* Per DSA imaging, lack of endovascular access to either middle meningeal artery, or origin of the middle meningeal artery other than from the external carotid artery\n* Known or suspected inability to adhere to study protocol or protocol requirements, as per discretion of the Investigator or treating provider","ALL","18 Years",{"count":71,"type":72},80,"ESTIMATED","INTERVENTIONAL",[75],"PHASE2","The goal of this clinical trial is to test whether injecting lidocaine into two blood vessels of the brain can help treat chronic headaches (migraines)",[78,79],"Refractory Migraine","Headache",[81,82,83,84],"headache","migraine","lidocaine","middle meningeal artery","NOT_YET_RECRUITING","2026-01-21",{"date":88,"type":89},"2026-01-23","ACTUAL",{"date":91,"type":72},"2026-03",{"date":93,"type":72},"2031-07",{"name":58,"class":6},1]