[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100557544":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":52,"collaborators":24,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":24,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":39,"whyStopped":24,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy volunteer","ACTIVE_COMPARATOR","healthy volunteers who will get omeprazol daily 2dd40 mg for 4 weeks",[13],"Drug: Omeprazole 40 MG",{"label":15,"type":10,"description":16,"interventionNames":17},"Sujbects with MASLD","Patients with MASLD who will get omeprazol daily 2dd40 mg for 4 weeks",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Omeprazole 40 MG","Proton pump inhibitor twice a day for 4 weeks",[9,15],null,[26],{"name":27,"affiliation":28,"role":29},"Max Nieuwdorp, prof","Amsterdam UMC, location AMC","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":24,"email":35},"Max Nieuwdorp, Prof","CONTACT","0031 20 5669111","m.nieuwdorp@amsterdamumc.nl",[37],{"facility":38,"status":39,"city":40,"state":24,"zip":24,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Amsterdam UMC location AMC","RECRUITING","Amsterdam","Netherlands","NL",{"type":44,"coordinates":45},"Point",[46,47],4.88969,52.37403,{"lat":47,"lon":46},[50],{"name":51,"role":33,"phone":34,"phoneExt":24,"email":35},"max nieuwdorp, MD PhD",{"type":29,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Max Nieuwdorp","Principle Investigator","100557544","phase-2-luminal-fructose-kinetics-martini-study-100557544",false,"NCT06539494","Luminal Fructose Kinetics (MARTINI Study)","Luminal Fructose Kinetics (MARTINI) (2024)","MARTINI","Inclusion Criteria:\n\nIn case of the healthy subject group:\n\n* Adult individuals, age \\> 18 \\\u003C65 years\n* Male or postmenopauzal females\n* BMI \\\u003C25\n* Ability to give informed consent In case of the MASLD\u002FMASH group\n* Adult individuals, age \\> 18 \\\u003C65 years\n* Male or postmenopauzal females\n* BMI \\> 25\n* Biopsy proven MASLD\u002FMASH\n* Ability to give informed consent\n\nExclusion Criteria:\n\n* History of sustained excess alcohol ingestion: daily consumption \\>30g\u002Fday (3 drinks per day) for males and \\>20 g\u002Fday (2 drinks per day) for females\n* Patients with diabetes\n* Bariatric surgery\n* Other forms of liver disease (e.g. Hepatitis B,C, Wilson disease, hemochromatosis)\n* Proton-pump inhibitor usage one year prior to study participation\n* GLP1, SGLT2i or insulin use\n* Antibiotic use for the past 3 months\n* Probiotic or symbiotic usage\n* Pregnant women\n* Chronic illness (including a known history of heart failure, renal failure (eGFR \\\u003C30 ml\u002Fmin), pulmonary disease, gastrointestinal disorders, or hematologic diseases), or other inflammatory diseases\n* Active infection\n* Use of ascal, clopidogrel or other platelet inhibition\n* Smoking\n* Blood thinners\n* Heart failure",true,"ALL","18 Years","65 Years",{"count":68,"type":69},22,"ESTIMATED","INTERVENTIONAL",[72],"PHASE2","In this study the investigators aim is to explore the dynamics of (small) intestinal fructose catabolism in humans and ethanol production in relation to small intestinal signalling pathways and changes in pH, using 13C fructose isotope tracing techniques complemented with direct luminal sampling via small intestinal catheter in biopsy proven MASLD\u002FMASH patients vs healthy (BMI\\\u003C25) subjects. Additionally the investigators will repeat the experiment after four weeks of administering omeprazole at a dose of 40 mg twice daily. Omeprazole is a proton pump inhibitor, known to elevate pH from 2-6.",[75],"MASLD",[77,75,78],"Fructose","Ethanol","2024-08-01",{"date":81,"type":82},"2024-08-06","ACTUAL",{"date":84,"type":82},"2024-07-01",{"date":86,"type":69},"2026-04",{"name":5,"class":6},1]