[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100572016":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":49,"centralContacts":53,"locations":59,"responsibleParty":79,"collaborators":81,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":32,"eligibilityCriteria":90,"healthyVolunteers":87,"sex":91,"minAge":92,"maxAge":32,"enrollmentInfo":93,"targetDuration":32,"studyType":96,"phases":97,"briefSummary":99,"conditions":100,"keywords":109,"overallStatus":62,"whyStopped":32,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"UNC Lineberger Comprehensive Cancer Center","OTHER",[8,15,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1","EXPERIMENTAL","Participants will receive study medication (memantine) and Get Real \\& Heel exercise guided by the therapist.",[13,14],"Drug: Memantine","Other: Exercise Intervention",{"label":16,"type":17,"description":18,"interventionNames":19},"Arm 2","PLACEBO_COMPARATOR","Participants have access to a library of pre-recorded Get Real \\& Heel sessions.",[20,21],"Drug: Placebo medication","Other: Exercise Control",{"label":23,"type":10,"description":24,"interventionNames":25},"Arm 3","Participants will receive study medication (memantine) and access to a library of pre-recorded Get Real \\& Heel sessions.",[13,21],[27,33,37,43],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DRUG","Memantine","memantine capsule",[9,23],null,{"type":28,"name":34,"description":35,"armGroupLabels":36,"otherNames":32},"Placebo medication","placebo capsule",[16],{"type":6,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"Exercise Intervention","Exercise Intervention participants will concurrently engage in remotely delivered Get Real \\& Heel, 3d\u002Fweek. Intensity for aerobic and strength-training components will progress as tolerated under the direction of a trained exercise physiologist.",[9],[42],"Get Real & Heel",{"type":6,"name":44,"description":45,"armGroupLabels":46,"otherNames":47},"Exercise Control","Exercise control will have access to a library of pre-recorded Get Real \\& Heel sessions.",[16,23],[48],"Exercise library",[50],{"name":51,"affiliation":5,"role":52},"Zev Nakamura, MD","PRINCIPAL_INVESTIGATOR",[54],{"name":55,"role":56,"phone":57,"phoneExt":32,"email":58},"Ashley M Hanson","CONTACT","+1 984-888-9244","Ashley_Hanson@med.unc.edu",[60],{"facility":61,"status":62,"city":63,"state":64,"zip":65,"country":66,"countryCode":67,"cosmosGeoPoint":68,"geoPoint":73,"contacts":74},"Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill","RECRUITING","Chapel Hill","North Carolina","27599","United States","US",{"type":69,"coordinates":70},"Point",[71,72],-79.05584,35.9132,{"lat":72,"lon":71},[75,78],{"name":76,"role":56,"phone":32,"phoneExt":32,"email":77},"Zev M Nakamura, MD","zev_nakamura@med.unc.edu",{"name":76,"role":52,"phone":32,"phoneExt":32,"email":32},{"type":80,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR",[82],{"name":83,"class":84},"National Institute on Aging (NIA)","NIH","100572016","phase-2-memantine-and-exercise-to-improve-cognitive-function-and-modulate-biological-pathways-of-cognitive-decline-during-chemotherapy-in-breast-cancer-100572016",false,"NCT06727773","Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer","Inclusion Criteria:\n\nIn order to participate in the study a subject must meet all of the eligibility criteria outlined below.\n\n* Female\n* Age ≥ 18 years at the time of consent.\n* Stage I-III Breast Cancer\n* Recommended chemotherapy\n* Enroll prior to 3rd cycle of chemotherapy\n* English-speaking\n\nExclusion Criteria:\n\n* Allergy to memantine\n* Previous chemotherapy (prior to the current regimen),\n* Severe cognitive impairment, defined by Blessed Orientation Memory Concentration Test Score ≥11\n* Myocardial infarction in the last 6 months\n* Cardiovascular or orthopedic limitations to exercise\n* Severe mental illness (i.e., schizophrenia or bipolar affective disorder)\n* Current alcohol or drug abuse\n* Inability to swallow capsules \\\u003C\u002F= 5mL\u002Fmin\n* CrCl \\\u003C\u002F= 5mL\u002Fmin","FEMALE","18 Years",{"count":94,"type":95},90,"ESTIMATED","INTERVENTIONAL",[98],"PHASE2","This randomized, placebo-controlled trial aims to assess the feasibility, acceptability, and preliminary efficacy of memantine and the University of Carolina (UNC)'s Get Real \\& Heel cancer exercise program (MEM+EX) in addressing cancer-related cognitive impairment (CRCI) and underlying CRCI biomarkers. Ninety stage I-III breast cancer patients during chemotherapy will be randomized into three groups: MEM+EX, memantine, or placebo. The study will evaluate recruitment, retention, adherence, acceptability, cognitive function, brain-derived neurotrophic factor (BDNF), inflammatory markers, and frailty at multiple time points.",[101,102,103,104,105,106,107,108],"Breast Cancer","Locally Advanced Breast Cancer","Cognitive Impairment","Cognitive Decline","Cognitive Change","Breast Cancer Stage I","Breast Cancer Stage II","Breast Cancer Stage III",[110,111,112,113,114],"chemotherapy","memantine","placebo-controlled","exercise","Get Real & Heel cancer exercise program","2026-05-01",{"date":117,"type":118},"2026-05-06","ACTUAL",{"date":120,"type":118},"2025-08-19",{"date":122,"type":95},"2029-06-15",{"name":5,"class":6},1]