[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615581":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":42,"responsibleParty":55,"collaborators":57,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":26,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":26,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":83,"whyStopped":26,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Taipei Medical University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Menthol Group","EXPERIMENTAL","Participants in this arm will wear gloves and socks containing menthol daily for four weeks.",[13],"Drug: Menthol gloves and socks",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Group","PLACEBO_COMPARATOR","Participants in this arm will wear placebo gloves and socks daily for four weeks. These are identical in appearance and material to those used in the treatment group but contain no active menthol compound.",[19],"Drug: Placebo gloves and socks",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Menthol gloves and socks","Participants will wear menthol-containing gloves and socks for five minutes per day, five days a week, over a four-week period.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo gloves and socks","Participants will wear gloves and socks with plain lotion for five minutes per day, five days a week, over a four-week period.",[15],[32],{"name":33,"affiliation":34,"role":35},"Yi-Hung Chen, PhD","International Master Program in Integrative Health, College of Chinese Medicine, China Medical University","STUDY_DIRECTOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Hsun-Hua Lee, MD-PhD","CONTACT","(886)02-27372181","kaorulei@yahoo.com.tw",[43],{"facility":5,"status":26,"city":44,"state":26,"zip":26,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Taipei","Taiwan","TW",{"type":48,"coordinates":49},"Point",[50,51],121.52639,25.05306,{"lat":51,"lon":50},[54],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},{"type":56,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[58],{"name":59,"class":6},"China Medical University, Taiwan","100615581","phase-2-menthol-for-improving-movement-and-sleep-in-parkinsons-disease-patients-100615581",false,"NCT07294469","Menthol for Improving Movement and Sleep in Parkinson's Disease Patients","Effect of Menthol on Motor Deficits and Sleep Disturbances in Patients With Parkinson's Disease","Inclusion Criteria:\n\n1. aged between 30 and 80 years (inclusive);\n2. diagnosed with idiopathic PD based on the Brain Bank criteria of the UK Parkinson's Disease Society less than 3 years;\n3. Hoehn and Yahr stages 1-3 and currently receiving treatment; experiencing sleep disorders with a Pittsburgh Sleep Quality Index (PSQI) \\> 5;\n4. has signed the informed consent form approved by the Institutional Review Board and dated accordingly;\n5. no changes in PD medications within four weeks prior to participating in this trial, and no dosage changes during the study period;\n6. able to use other medications that may affect sleep, except those explicitly prohibited, provided the dosage has been stable for the four weeks before screening and remains unchanged during the study.\n\nExclusion Criteria:\n\n1. menthol allergy;\n2. pregnant and breastfeeding women;\n3. diagnosed with secondary and atypical PD;\n4. patients with conditions such as uremia, cirrhosis, congestive heart failure with pulmonary edema, coagulation disorders, epilepsy, alcoholism, drug abuse, or\n5. deemed unsuitable for participation in this study by the principal investigator.","ALL","30 Years","80 Years",{"count":71,"type":72},80,"ESTIMATED","INTERVENTIONAL",[75],"PHASE2","Parkinson's disease (PD) is a progressive neurological disorder characterized by both motor and non-motor symptoms due to the degeneration of dopamine-producing neurons. There is currently no cure. Menthol, a natural compound that activates TRPM8 receptors, has shown neuroprotective and motor function benefits in preclinical PD models. In mice, distal limb immersion in menthol improved dopamine neuron survival and motor performance. Similar menthol-based interventions improved outcomes in a stroke model and a clinical trial with stroke patients. This study investigates whether topical menthol can offer therapeutic benefits for individuals with PD.",[78],"Parkinson's Disease",[80,78,81,82],"Menthol","Motor Deficits","Sleep Disturbances","NOT_YET_RECRUITING","2026-01-05",{"date":86,"type":87},"2026-01-08","ACTUAL",{"date":89,"type":72},"2025-12-15",{"date":91,"type":72},"2027-07-31",{"name":5,"class":6},1]