[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584261":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":18,"centralContacts":19,"locations":28,"responsibleParty":45,"collaborators":18,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":18,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":31,"whyStopped":18,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Fondazione Epatocentro Ticino","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Methylene Blue","EXPERIMENTAL","Subjects will be initially treated with an initial dose of 200mg\u002Fday for 8 weeks at which point the investigators will assess the effect of the treatment.\n\nThose patients that obtain a \"complete response\" will continue their treatment up to a total of 24 weeks with the same dose. Those who do not reach a \"complete response\" will be exposed to the next higher dose of 400mg\u002Fday for the following 8 weeks and the investigators will then again assess the effect of the treatment.\n\nThose patients that obtain a \"complete response\" will continue their treatment up to a total of 24 weeks with the same dose. Those who do not reach a \"complete response\" will be exposed to the next higher dose of 600mg\u002Fday for the following 8 weeks and the investigators will then assess the effect of the treatment.",[13],"Drug: Methylene Blue",[15],{"type":16,"name":9,"description":11,"armGroupLabels":17,"otherNames":18},"DRUG",[9],null,[20,25],{"name":21,"role":22,"phone":23,"phoneExt":18,"email":24},"Andreas Cerny","CONTACT","0041 91 910 6570","andreas.cerny@hin.ch",{"name":26,"role":22,"phone":23,"phoneExt":18,"email":27},"Chiara De Luca","chiara.deluca@hin.ch",[29],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Epatocentro Ticino","RECRUITING","Lugano","Canton Ticino","6900","Switzerland","CH",{"type":38,"coordinates":39},"Point",[40,41],8.96004,46.01008,{"lat":41,"lon":40},[44],{"name":21,"role":22,"phone":23,"phoneExt":18,"email":24},{"type":46,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100584261","phase-2-methylene-blue-treatment-of-chronic-hepatitis-b-virus-infection-100584261",false,"NCT06887036","Methylene Blue Treatment of Chronic Hepatitis B Virus Infection","Methylene Blue Treatment of Chronic Hepatitis B Virus Infection: a Pilot Study","MB_HBV","Inclusion Criteria:\n\n* Signed informed consent\n* Age ≥ 18 and \\\u003C 80 years\n* Microbiologically confirmed chronic Hepatitis B Virus infection (according to the old terminology \"inactive HBV carrier\")\n* HBsAg levels within 20-15'000 IU\u002Fml measured at the at least twice at 6-18 months apart\n* HBV DNA PCR levels within 1'000-20'000 IU\u002Fml measured at least twice at 6-18 months apart\n* Negative pregnancy test in women of child-bearing age\n\nExclusion Criteria:\n\n* Documented refusal to participate in the study\n* Known G-6-Phophatase deficiency\n* Treatment with a serotoninergic drug\n* Ongoing treatment with a nucleos(-t)ide treatment\n* Clinically relevant concomitant liver disease\n* GPT \\> 2xULN\n* Fibroscan of \\> 8.0 KPa obtained ≤ 12 months before Visit 0\u002FScreening\n* HBeAg positivity\n* Anti HDV antibody positivity\n* Breastfeeding women","ALL","18 Years","79 Years",{"count":59,"type":60},10,"ESTIMATED","INTERVENTIONAL",[63],"PHASE2","HBV infection is a global public health problem. It is estimated that there are more than 250 million HBV carriers worldwide, of whom approximately 600,000 die each year from HBV-related liver disease. Diagnosis and treatment depend on the stage of infection, the degree of liver inflammation, and the progression of fibrosis. Patients with HBeAg-positive or -negative hepatitis are usually treated with nucleos(-t)ide analogues. This treatment inhibits HBV reverse transcriptase and reduces viral replication, but does not affect HBsAg production. Treatment must be continued for life in most cases and is associated with high cumulative costs and the risk of development of resistance.\n\nRecently, it has been shown that patients who show a decrease in their HBsAg levels are more likely to become HBsAg negative, seroconvert and be able to stop antiviral treatment, which is the ultimate goal of treatment, but unfortunately rarely achieved. Methylene blue (MB) has been shown to have an effect on HBsAg levels in vitro, making it a promising test for a new treatment for HBV.\n\nThis is an explorative pilot study, open label, dose-escalation, single center clinical trial on the efficacy of MB against HBV infection.\n\nPrimary objective is to assess the efficacy of incremental doses of MB against hepatitis B virus in patients with chronic hepatitis B assessed by the reduction of both the HBsAg and HBV DNA levels after 6 months of treatment and 6 months of follow-up.\n\nParticipant will be treated for 6 months with MB 100 mg capsules, and then followed up for a further 6 months. The initial dose of MB might be increased if the patient is a non-responder.",[66],"Chronic HBV Infection",[68,69,9,70],"HBV","chronic HBV","MB","2025-08-13",{"date":73,"type":74},"2025-08-17","ACTUAL",{"date":76,"type":60},"2025-09",{"date":78,"type":60},"2026-10-31",{"name":5,"class":6},1]