[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100550414":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":32,"locations":37,"responsibleParty":55,"collaborators":57,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":24,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":40,"whyStopped":24,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Yale University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"mindfulness-based Neurofeedback","EXPERIMENTAL","Participants will participate in one session of mindfulness-based fMRI neurofeedback followed by 20 weeks of remote online weekly Dialectical Behavior Therapy skills group.",[13],"Behavioral: mindfulness-based Neurofeedback",{"label":15,"type":6,"description":16,"interventionNames":17},"control Neurofeedback","Participants will participate in one session of control fMRI neurofeedback followed by 20 weeks of remote online weekly Dialectical Behavior Therapy skills group.",[18],"Other: control Neurofeedback",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","Participants will complete one session of mindfulness-based fMRI neurofeedback prior to 20 weeks of remote online weekly DBT skills group.",[9],null,{"type":6,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"Participants will complete one session of control fMRI neurofeedback prior to 20 weeks of remote online weekly DBT skills group.",[15],[29],{"name":30,"affiliation":5,"role":31},"Sarah K Fineberg, MD PhD","PRINCIPAL_INVESTIGATOR",[33],{"name":30,"role":34,"phone":35,"phoneExt":24,"email":36},"CONTACT","203-974-7265","sarah.fineberg@yale.edu",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Connecticut Mental Health Center","RECRUITING","New Haven","Connecticut","06519","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-72.92816,41.30815,{"lat":50,"lon":49},[53],{"name":54,"role":34,"phone":35,"phoneExt":24,"email":36},"Sarah K Fineberg, MD\u002FPhD",{"type":56,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[58,60],{"name":39,"class":59},"UNKNOWN",{"name":61,"class":62},"National Institute of Mental Health (NIMH)","NIH","100550414","phase-2-mindfulness-based-neurofeedback-to-augment-psychotherapy-for-adults-with-borderline-personality-disorder-100550414",false,"NCT06446765","Mindfulness-based Neurofeedback to Augment Psychotherapy for Adults With Borderline Personality Disorder","Mindfulness-based Neurofeedback to Augment Dialectical Behavior Therapy (DBT) for Adults With Borderline Personality Disorder (Aim 1)","MIND-BPD","Inclusion criteria:\n\n* age 18-60,\n* be able to provide written informed consent,\n* meet criteria for BPD on semi-structured clinical interview,\n* able to plan to keep any prescribed medications and psychotherapy constant during the study\n* fluent in English.\n\nExclusion criteria:\n\n* current DBT psychotherapy outside the study\n* lifetime primary psychotic disorder\n* manic episode in the last one year\n* developmental disorder (e.g. autism)\n* history of learning disorder\n* severe substance use disorder in the last 3 months\n* active suicidal ideation with intent or plan in the past 3 months\n* history of major medical or neurologic disorder\n* MRI contraindications, including pregnancy\n* poor performance on reading task (WRAT \\> 11 errors)\n* newly prescribed medications in the past 8 weeks\n* daytime sedating medications (e.g. benzodiazepines, opiates, sedating neuroleptics)\n* any scheduled daily benzodiazepines\n* change in psychotherapy type or frequency in the past 12 weeks.\n* At the discretion of the study PI\n\nEligibility will be determined by study personnel.","ALL","18 Years","60 Years",{"count":75,"type":76},150,"ESTIMATED","INTERVENTIONAL",[79],"PHASE2","The purpose of this study is to test the ability of mindfulness-based real time functional magnetic resonance imaging (fMRI) neurofeedback (mbNF) to increase the benefits of evidence-based psychotherapy for adults with Borderline Personality Disorder (BPD).",[82],"Borderline Personality Disorder",[84,85],"fMRI neurofeedback","mindfulness","2026-06-08",{"date":88,"type":89},"2026-06-09","ACTUAL",{"date":91,"type":89},"2025-03-13",{"date":93,"type":76},"2026-10-30",{"name":5,"class":6},1]