[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596529":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":26,"centralContacts":33,"locations":39,"responsibleParty":54,"collaborators":26,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":26,"eligibilityCriteria":63,"healthyVolunteers":60,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":26,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":26,"overallStatus":42,"whyStopped":26,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Fudan University","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Rare Tumor 2","EXPERIMENTAL","Patients with extramammary PAGET's disease, after PD1 failure.",[13],"Combination Product: cisplatin-based chemotherapy",{"label":15,"type":10,"description":16,"interventionNames":17},"Rare Tumor 3","Patients with advanced adrenocortical carcinoma, following PD1 failure.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Rare Tumor 4","Patients with advanced urachal cancer, after PD1 failure.",[13],{"label":23,"type":24,"description":25,"interventionNames":26},"Arm 1","NO_INTERVENTION","Patients with advanced urothelial cancer in whom PD-1 and vedicitumumab had failed.",null,[28],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":26},"COMBINATION_PRODUCT","cisplatin-based chemotherapy","Patients were required to have a creatinine clearance of more than 60 and to receive standard doses of cisplatin and gemcitabine (gemcitabine 1000mg \u002Fm2 on day 1.8 and cisplatin 70 mg \u002Fm2 on day 1, q3w). A total of 4-6 courses of treatment were performed.",[9,15,19],[34],{"name":35,"role":36,"phone":37,"phoneExt":26,"email":38},"Sheng Zhang, PhD","CONTACT","86+18017317442","568841700@qq.com",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":26},"Shanghai Cancer Center, Fudan University","RECRUITING","Shanghai","Shanghai Municipality","200000","China","CN",{"type":49,"coordinates":50},"Point",[51,52],121.45806,31.22222,{"lat":52,"lon":51},{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Sheng Zhang","Dr.","100596529","phase-2-multi-cohort-single-arm-phase-ii-study-of-the-efficacy-and-side-effects-of-cisplatin-plus-gemcitabine-in-the-treatment-of-pd1-failure-or-intensive-treatment-of-some-rare-tumors-100596529",false,"NCT07046650","Multi-cohort, Single-arm, Phase II Study of the Efficacy and Side Effects of Cisplatin Plus Gemcitabine in the Treatment of PD1 Failure or Intensive Treatment of Some Rare Tumors","Inclusion Criteria:\n\n* 1\\. Written informed consent was obtained before enrollment. 2. Age ≥18 years old; 3. Patients with corresponding cancer confirmed by histological and\u002For cytological examination; 4. Consent to treatment; 5. ECOG score: 0-1; 6. Previous PD-1 therapy failure; 7. At least one measurable lesion (≥10 mm on CT scan for non-nodal lesions and ≥15 mm on CT scan for nodal lesions according to RECIST criteria).\n\n  8\\. Have adequate organ function: 9. Blood routine: Absolute Neutrophil Count (ANC) 1.5×109\u002FL, Platelet (PLT) ≥70×109\u002FL, Hemoglobin (HGB) ≥80g\u002FL; 10. Liver function: serum Total Bilirubin (TBIL) ≤1.5× Upper Limit of Normal Value (ULN); Alanine Aminotransferase (ALT) and Aspartate aminotransferase (AST) ≤3×ULN; Serum albumin ≥28 g\u002FL; Alkaline Phosphatase (ALP) ≤5×ULN; Patients who met the above criteria after conventional liver-protective therapy and could be stable for at least 1 week could be enrolled after investigator's evaluation.\n\n  11\\. Renal function: creatinine clearance ≥60 mL\u002Fmi (using the standard Cockcroft-Gault formula) : 12. Coagulation: International Normalized Ratio (INR) ≤1.5 \u002FPT≤1.5×ULN, aPTT≤1.5×ULN; If the subject is receiving anticoagulant therapy, as long as the PT and INR are within the prescribed range of anticoagulant drugs 13. Estimated survival time ≥3 months; 14. Contraception during treatment 15. Ability to adhere to study access schedules and other protocol requirements.\n\nExclusion Criteria:\n\n* 1\\. Poor patient compliance; 2. Prior exposure to cisplatin and\u002For gemcitabine and documented progression 3. With ≥ grade 2 myocardial ischemia or myocardial infarction, arrhythmia (QTc≥470ms), and ≥ grade 2 congestive heart failure (New York Heart Association \\[NYHA\\] classification); 4. Severe active or uncontrolled infection (≥CTCAE grade 2 infection) requiring systemic antibacterial, antifungal, or antiviral therapy, including pulmonary tuberculosis infection.\n\n  5\\. Active hepatitis (transaminase did not meet the inclusion criteria, hepatitis B reference: HBV DNA≥2000 IU\u002Fml or ≥104 copies \u002Fml; Hepatitis C reference: HCV RNA≥2000 IU\u002Fml or ≥104 copies \u002Fml; After nucleotide antiviral therapy, those below the above criteria can be enrolled). Chronic hepatitis B virus carriers with HBV DNA \\\u003C 104 IU\u002Fml could only be enrolled if they received antiviral therapy at the same time during the trial.\n\n  6\\. A history of immunodeficiency, including HIV positive or other acquired or congenital immunodeficiency diseases, or a history of organ transplantation; 7. Severe nausea, headache, insomnia, fatigue, somnolence, dry mouth, dizziness and constipation; 8. Patients with a history of active tuberculosis; 9. Patients who underwent major surgical treatment, open biopsy, or significant traumatic injury within 28 days before the initiation of study treatment; Or have a wound or fracture that has not healed for a long time; 10. Currently participating or having participated in another clinical investigator within 4 weeks before study initiation 11. Patients with a history of severe allergies 12. Is at risk for bleeding, or has coagulopathy, or is receiving thrombolytic therapy 13. People who have a history of psychotropic drug abuse and cannot quit or have mental disorders 14. Subjects who, in the investigator's judgment, had a concomitant medical condition that seriously compromised the safety of the subjects or interfered with the completion of the study, or who were deemed to be ineligible for enrollment for any other reason. \"There was a clear previous history of neurological and psychiatric disorders, such as dementia, epilepsy, or seizure prone episodes.\n\n  15\\. The presence of concomitant diseases (such as severe diabetes mellitus, thyroid disease, and psychosis), or serious and\u002For unstable medical, psychiatric, or other conditions (including laboratory abnormalities) that, in the judgment of the investigators, seriously compromise the safety of the subjects or prevent the subjects from completing the study, or the presence of serious and\u002For unstable medical, psychiatric, or other conditions (including laboratory abnormalities) that affect the safety of the patients or prevent the patients from providing informed consent, \"Or the presence of any psychological, family, sociological, or geographic factors that affect the study protocol and follow-up plan.\n\n  16\\. The investigator did not consider it appropriate to participate in the trial for any reason","ALL","18 Years","75 Years",{"count":68,"type":69},84,"ESTIMATED","INTERVENTIONAL",[72],"PHASE2","This is a multi-cohort, single-arm, phase II study of the efficacy and side effects of cisplatin plus gemcitabine in the treatment of PD1 failure or intensive treatment of some rare tumors",[75],"Advanced Solid Tumors","2025-06-30",{"date":78,"type":79},"2025-07-01","ACTUAL",{"date":81,"type":79},"2025-01-01",{"date":83,"type":69},"2028-07-31",{"name":56,"class":6},1]