[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100576216":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":11,"centralContacts":11,"locations":26,"responsibleParty":77,"collaborators":79,"id":88,"slug":89,"hasResults":90,"nctId":91,"briefTitle":92,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":90,"sex":95,"minAge":96,"maxAge":11,"enrollmentInfo":97,"targetDuration":11,"studyType":100,"phases":101,"briefSummary":104,"conditions":105,"keywords":112,"overallStatus":48,"whyStopped":11,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":126,"completionDateStruct":127,"leadSponsor":129,"locationsCount":130},{"fullName":5,"class":6},"KU Leuven","OTHER",[8,14,17],{"label":9,"type":10,"description":11,"interventionNames":12},"Oesophagogastric adenocarcinoma (OGA)","EXPERIMENTAL",null,[13],"Diagnostic Test: [18F]AlF-FAPI-74 PET\u002FCT",{"label":15,"type":10,"description":11,"interventionNames":16},"Pancreatic ductal adenocarcinoma (PDAC)",[13],{"label":18,"type":10,"description":11,"interventionNames":19},"Clinically challenging situations",[13],[21],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":11},"DIAGNOSTIC_TEST","[18F]AlF-FAPI-74 PET\u002FCT","A \\[18F\\]AlF-FAPI-74 PET\u002FCT will be performed at the same site of the screening visit (UZ Leuven, UZ Gent or UZ Antwerpen). Subjects are required to be sober four hours before the scan. The patient will get an IV line, through which the \\[18F\\]AlF-FAPI-74 will be injected in one bolus (3,5 MBq\u002Fkg). After 60 minutes, the acquisition on the PET\u002FCT scan will take place. The CT will be a low dose CT with oral contrast. After the scan, participants will be observed at the department in case of adverse events. During this time, the participant can fill in the PRO. The estimated duration of this visit is three hours. If the patient receives neo-adjuvant therapy, a second \\[18F\\]AlF-FAPI-74 PET\u002FCT will be performed maximum one month before surgery. If the planned surgery gets postponed after the second \\[18F\\]AlF-FAPI-74 PET\u002FCT has been performed, we will have the possibility to perform one additional (i.e. third) \\[18F\\]AlF-FAPI-74 PET\u002FCT, before the final surgery.",[18,9,15],[27,46,62],{"facility":28,"status":29,"city":30,"state":11,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"University Hospital Antwerp (UZA)","NOT_YET_RECRUITING","Edegem","2650","Belgium","BE",{"type":35,"coordinates":36},"Point",[37,38],4.44504,51.15662,{"lat":38,"lon":37},[41,44],{"name":42,"role":43,"phone":11,"phoneExt":11,"email":11},"Sigrid Stroobants, Prof. Dr.","CONTACT",{"name":42,"role":45,"phone":11,"phoneExt":11,"email":11},"PRINCIPAL_INVESTIGATOR",{"facility":47,"status":48,"city":49,"state":11,"zip":50,"country":32,"countryCode":33,"cosmosGeoPoint":51,"geoPoint":55,"contacts":56},"University Hospital Ghent","RECRUITING","Ghent","9000",{"type":35,"coordinates":52},[53,54],3.71667,51.05,{"lat":54,"lon":53},[57,61],{"name":58,"role":43,"phone":59,"phoneExt":11,"email":60},"Karen Geboes, Prof. Dr.","+32 9 332 05 30","hiruz@uzgent.be",{"name":58,"role":45,"phone":11,"phoneExt":11,"email":11},{"facility":63,"status":48,"city":64,"state":11,"zip":65,"country":32,"countryCode":33,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"UZ Leuven","Leuven","3000",{"type":35,"coordinates":67},[68,69],4.70093,50.87959,{"lat":69,"lon":68},[72,76],{"name":73,"role":43,"phone":74,"phoneExt":11,"email":75},"Christophe Deroose, Prof. Dr.","+3216343715","christophe.deroose@uzleuven.be",{"name":73,"role":45,"phone":11,"phoneExt":11,"email":11},{"type":45,"investigatorFullName":73,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Head of Clinic Nuclear Medicine, UZ Leuven - Full Professor, KU Leuven",[80,82,84,86],{"name":81,"class":6},"University Hospital, Ghent",{"name":83,"class":6},"University Hospital, Antwerp",{"name":85,"class":6},"Universitaire Ziekenhuizen KU Leuven",{"name":87,"class":6},"Kom Op Tegen Kanker","100576216","phase-2-multicenter-validation-trial-of-18falf-fapi-74-for-pet-imaging-of-cancer-associated-fibroblasts-through-fibroblast-activation-protein-inhibitors-fapi-in-different-tumor-types-100576216",false,"NCT06782412","Multicenter Validation Trial of [18F]AlF-FAPI-74 for PET Imaging of Cancer-associated Fibroblasts Through Fibroblast Activation Protein Inhibitors (FAPI) in Different Tumor Types","FAPIDO","Inclusion Criteria OGA:\n\n1. Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures.\n2. Age 18 or older.\n3. New histologic or cytologic proven diagnosis of oesophagogastric adenocarcinoma.\n4. Patient underwent a \\[18F\\]FDG PET\u002FCT.\n5. TNM classification: cT1-4N0-3M0\n\nInclusion Criteria PDAC:\n\n1. Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures.\n2. Age 18 or older.\n3. New histologic or cytologic proven diagnosis of pancreatic ductal adenocarcinoma.\n4. Patient underwent a \\[18F\\]FDG PET\u002FCT or conventional staging with CT or MRI.\n5. TNM classification: cT1-4N0-2M0-1, with the exception of upfront resectable patients.\n\nInclusion Criteria Clinically challenging cohort:\n\n1. Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures.\n2. Age 18 or older.\n3. Histologic or cytologic proven diagnosis of a malignancy.\n4. Patient underwent a \\[18F\\]FDG PET\u002FCT.\n5. Unexplained symptoms, complaints, biochemical or imaging (scintigraphy, PET, CT, MR) findings.\n\nExclusion Criteria:\n\n1. Participant is mentally or legally incapacitated, doesn't understand the study design or is not willing or capable to undergo all study-specific procedures.\n2. Any disorder or condition, which in the Investigator's opinion might jeopardise the participant's safety or compliance with the protocol.\n3. Any prior or concomitant treatment(s) that might jeopardise the participant's safety or that would compromise the integrity of the Trial.\n4. Female who is pregnant (urinary hCG test can be performed in case of doubt), breast-feeding or intends to become pregnant or is of child-bearing potential and not using an adequate, highly effective contraceptive (with a relatively high Pearl Index: natural methods, minipill outside postpartum period, spermicides or condoms in monotherapy or no usage of contraception when sexually active are not accepted).\n5. Participation in an interventional Trial with an investigational medicinal product (IMP) or device when the trial designs are not considered compatible by the study team.\n6. Participation in a clinical scientific study in the last 12 months with a radiation exposure caused by the experimental procedures greater than 1 mSv.\n7. Participant has a known hypersensitivity to \\[18F\\]AlF-FAPI-74 or the used excipients.","ALL","18 Years",{"count":98,"type":99},109,"ESTIMATED","INTERVENTIONAL",[102,103],"PHASE2","PHASE3","The aim of the project is to demonstrate superior detection ratio of \\[18F\\]AlF-FAPI-74 PET\u002FCT compared to \\[18F\\]FDG PET\u002FCT or conventional imaging in treatment-naïve, newly diagnosed patients with oesophagogastric adenocarcinoma (clinical T1-4N0-3M0) and pancreatic ductal adenocarcinoma (clinical T1-4N0-2M0-1) and describe the clinical utility of \\[18F\\]AlF-FAPI-74 PET\u002FCT in oncological patients with a clinically challenging situation.",[106,107,108,109,110,111],"Oesophageal Cancer","Gastric Cancer","Pancreatic Ductal Adenocarcinoma","FAP","Oncology","Oncologic Disorders",[113,114,18,115,116,117,118,119,120,110,121],"Oesophagogastric adenocarcinoma","Pancreatic ductal adenocarcinoma","[18F]-FDG","[18F]-FAPI-74","[18F]AIF-FAPI-74","Positron emission tomography","PET","Nuclear imaging","Prospective","2025-02-06",{"date":124,"type":125},"2025-02-07","ACTUAL",{"date":122,"type":125},{"date":128,"type":99},"2027-12",{"name":5,"class":6},3]