[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100488565":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":52,"collaborators":55,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":23,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":78,"overallStatus":84,"whyStopped":23,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Yale University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"THC","EXPERIMENTAL","Participants will receive THC into a rapidly flowing IV infusion.",[13],"Drug: THC",{"label":15,"type":6,"description":16,"interventionNames":17},"Placebo","Participants will receive an equivalent amount (about 1-2 ml) of placebo (sterile 190 proof USP ethanol). The placebo does not produce any measurable blood alcohol levels or subjective\u002Fbehavioral effects.",[18],"Other: Placebo",[20,24],{"type":21,"name":9,"description":11,"armGroupLabels":22,"otherNames":23},"DRUG",[9],null,{"type":6,"name":15,"description":16,"armGroupLabels":25,"otherNames":23},[15],[27],{"name":28,"affiliation":5,"role":29},"Jose Cortes-Briones, PhD","PRINCIPAL_INVESTIGATOR",[31],{"name":28,"role":32,"phone":33,"phoneExt":34,"email":35},"CONTACT","203-903-5711","5539","jose.briones@yale.edu",[37],{"facility":38,"status":23,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"VA Connecticut Healthcare System, Yale School of Medicine","West Haven","Connecticut","06516","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-72.94705,41.27065,{"lat":48,"lon":47},[51],{"name":28,"role":29,"phone":23,"phoneExt":23,"email":23},{"type":29,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Jose Cortes","Assistant Professor of Psychiatry",[56],{"name":57,"class":58},"National Institute on Drug Abuse (NIDA)","NIH","100488565","phase-2-multimodal-magnetoencephalography-and-electroencephalography-exploration-of-the-acute-effects-of-thc-exposure-on-neural-noise-and-information-transmission-within-working-memory-networks-100488565",false,"NCT05641766","Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of THC Exposure on Neural Noise and Information Transmission Within Working Memory Networks","THC-MEG","Inclusion Criteria:\n\n* Cannabis use at least once in the past 12 months\n* No cannabis use during the course of the study confirmed with negative urine toxicology at screening and on each test day\n* Good physical and mental health\n\nExclusion Criteria:\n\n* Cannabis naïve individuals\n* Lifetime or current medical, psychiatric or psychosocial disorders or history that is deemed unsuitable for participation in the study per PI discretion.\n* Positive pregnancy test, lactation, or refusal to practice birth control for the duration of the study and for two weeks following completion\n* Major current or recent stressors\n* Positive urine drug test\n* Contraindication for Magnetic Resonance Imaging\n* Treatment with psychotropic medication as per discretion of the PI\n* IQ less than 80\n* Weight exceeding 166kg\n* Diagnosis of major psychotic or manic disorder in first-degree relatives.",true,"ALL","21 Years","65 Years",{"count":71,"type":72},50,"ESTIMATED","INTERVENTIONAL",[75],"PHASE2","The purpose of this study is to use non-invasive brain imaging methods (MEG and EEG) to characterize the effects of THC on brain activity during learning.",[9],[79,80,9,15,81,82,83],"MEG","EEG","Working Memory","Neural Noise","Cognitive Process","NOT_YET_RECRUITING","2025-06-04",{"date":87,"type":88},"2025-06-10","ACTUAL",{"date":90,"type":72},"2025-08-31",{"date":92,"type":72},"2025-12-01",{"name":5,"class":6},1]