[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610443":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":54,"collaborators":56,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":25,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":25,"overallStatus":86,"whyStopped":25,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"University of Arizona","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"N-Acetylcysteine (NAC)","EXPERIMENTAL","Intervention: Oral N-acetylcysteine capsules, 600 mg twice daily.\n\nTiming\u002FDuration: Begin the evening before surgery (≤24 h pre-op) and continue through Post-op Day 14 (total 15 days; bottle overfilled to cover missed doses).\n\nAdministration: Self-administered at home; counseling at baseline dispense; pill diary + pill counts.\n\nConcomitant care: All peri-operative care per standard of care (SoC), including multimodal analgesia; no high-dose antioxidant supplements; nitrates excluded.\n\nObjective: Test whether peri-operative NAC improves early pain, function, and recovery via redox-immune modulation.",[13],"Drug: NAC",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Intervention: Matched inert capsules (e.g., microcrystalline cellulose), identical in size\u002Fappearance\u002Flabeling to NAC.\n\nTiming\u002FDuration: 600 mg-equivalent capsule count, twice daily, evening before surgery through Post-op Day 14.\n\nAdministration: Same counseling, diary, and adherence checks as NAC arm.\n\nConcomitant care: Identical SoC allowances\u002Frestrictions as NAC arm.",[19],"Drug: NAC 0mg\u002Fday (Placebo)",[21,26],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"DRUG","NAC",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"NAC 0mg\u002Fday (Placebo)","Intervention: Matched inert capsules (e.g., microcrystalline cellulose), identical in size\u002Fappearance\u002Flabeling to NAC.\n\nTiming\u002FDuration: 600 mg-equivalent capsule count, twice daily, evening before surgery through Post-op Day 14.\n\nAdministration: Same counseling, diary, and adherence checks as NAC arm.\n\nConcomitant care: Identical SoC allowances\u002Frestrictions as NAC arm.\n\nRandomization\u002FBlinding: 1:1, stratified by surgery type (upper- vs lower-extremity); double-blind (participants, investigators, assessors).\n\nPrimary comparisons: Early postoperative pain and function (e.g., PROMIS-PI\u002FPF, QuickDASH or LEFS), opioid consumption; safety\u002Ftolerability.",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Valerio Tonelli Enrico, PT, PhD, MSCE","CONTACT","17068097067","vte@arizona.edu",[37],{"facility":38,"status":25,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Banner Health","Tucson","Arizona","85721","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-110.92648,32.22174,{"lat":48,"lon":47},[51],{"name":52,"role":33,"phone":53,"phoneExt":25,"email":35},"Valerio Tonelli Enrico","7068097067",{"type":55,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[57],{"name":58,"class":6},"Banner University Medical Center","100610443","phase-2-nac-repair-for-post-surgical-pain-100610443",false,"NCT07227649","NAC-REPAIR for Post-surgical Pain","NAC-REPAIR: N-Acetylcysteine-facilitated Redox-Immune Modulation for Post-surgical Analgesia and Injury Recovery","Inclusion Criteria:\n\n* Elective outpatient hand\u002Fupper-extremity or foot\u002Fankle surgery (single site; same-day discharge)\n* Baseline visit feasible ≤14 days pre-op\n* Can complete surveys\u002Fblood draw\n* Provides informed consent\n* Willing to follow dosing schedule and avoid restricted supplements\u002Fmeds\n\nExclusion Criteria:\n\n* Allergy to NAC\u002Fcapsule components □ NAC or high-dose antioxidants in past 14 days (unwilling to stop)\n* Chronic daily opioids ≥3 months or OUD\u002Fmaintenance therapy □ Pregnant\u002Fbreastfeeding or no contraception as applicable\n* Daily nitrates (nitroglycerin\u002Fisosorbide) □ Planned \\>24h admission, multistage\u002Ftrauma case □ Other interventional study within 30 days\n* Unable to swallow capsules \u002F malabsorption surgery affecting oral meds","ALL","18 Years","75 Years",{"count":70,"type":71},80,"ESTIMATED","INTERVENTIONAL",[74],"PHASE2","This pilot asks whether peri-operative N-acetylcysteine (NAC) improves recovery after common outpatient hand\u002Ffoot-ankle surgery-specifically, does NAC reduce pain and opioid use and enhance function by modulating redox-inflammatory pathways? Primary objectives are to establish feasibility (accrual, adherence, follow-up), estimate NAC vs placebo effects on pain, function, and opioid consumption, and characterize inflammatory signatures that may predict response.\n\nMethods: a single-site, double-blind, 1:1 randomized trial (N≈80) comparing NAC 1,200 mg twice daily for 14 days (starting pre-op) vs matching placebo; daily e-diaries for POD0-14; standardized outcomes (PROMIS Pain Interference; QuickDASH or FAAM; PGIC; opioid MME); and small blood draws pre-surgery and at two follow-up visits for cytokine profiling.",[77,78,79,80,81,82,83,84,85],"Carpal Tunnel Surgery","Trigger Finger Disorder","De Quervain Syndrome","Guyon's Canal","Dupuytren Contracture","Morton Neuroma","Tarsal Tunnel Syndrome","Plantar Fasciopathy","Peroneal Nerve Entrapment","NOT_YET_RECRUITING","2025-11-12",{"date":89,"type":90},"2025-11-14","ACTUAL",{"date":92,"type":71},"2026-01-15",{"date":94,"type":71},"2027-07-15",{"name":5,"class":6},1]