[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100368194":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":39,"responsibleParty":58,"collaborators":18,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":18,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":18,"enrollmentInfo":69,"targetDuration":18,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":80,"overallStatus":42,"whyStopped":18,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"1\u002F Arm 1","EXPERIMENTAL","Study natural history of VHL pancreatic neuroendocrine tumors with yearly 68-Gallium DOTATATE PET\u002FCT research scans.",[13],"Drug: 68-Gallium DOTATATE",{"label":15,"type":16,"description":17,"interventionNames":18},"2\u002F Arm 2","NO_INTERVENTION","Study natural history of VHL pancreatic neuroendocrine tumors without research scans.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DRUG","68-Gallium DOTATATE","68-Gallium DOTATATE, to be used in yearly PET\u002FCT research scans",[9],[26],{"name":27,"affiliation":28,"role":29},"Naris Nilubol, M.D.","National Cancer Institute (NCI)","PRINCIPAL_INVESTIGATOR",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":18,"email":35},"Kristine J Villaruel","CONTACT","(240) 858-7033","kristinejoy.villaruel@nih.gov",{"name":27,"role":33,"phone":37,"phoneExt":18,"email":38},"(240) 760-6154","niluboln@mail.nih.gov",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"National Institutes of Health Clinical Center","RECRUITING","Bethesda","Maryland","20892","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-77.10026,38.98067,{"lat":52,"lon":51},[55],{"name":56,"role":33,"phone":57,"phoneExt":18,"email":18},"For more information at the NIH Clinical Center contact National Cancer Institute Referral Office","888-624-1937",{"type":59,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100368194","phase-2-natural-history-and-management-of-von-hippel-lindau-vhl-associated-pancreatic-neuroendocrine-tumors-100368194",false,"NCT04074135","Natural History and Management of Von Hippel-Lindau (VHL) Associated Pancreatic Neuroendocrine Tumors","Evaluation of the Natural History and Management of Von Hippel-Lindau (VHL) Associated Pancreatic Neuroendocrine Tumors","* INCLUSION CRITIERIA:\n\n  1. Participants who have been diagnosed with VHL using the following criteria:\n\n     \\-- Identification of a heterozygous germline pathogenic variant in VHL by molecular genetic testing.\n\n     or\n\n     \\-- Clinical criteria\n  2. Participants with at least 1 pancreatic manifestation of VHL as documented on any non-invasive imaging study. These manifestations may include:\n\n     * Pancreatic cyst(s)\n     * Solid lesions suspicious for microcystic adenoma(s)\n     * Solid enhancing lesions suspicious for PNET(s)\n     * Any other solid lesion(s) of the pancreas\n  3. Age greater than or equal to 12 years.\n  4. Ability of participant to understand and the willingness to sign a written informed consent document.\n\nEXCLUSION CRITERIA:\n\n1\\. Inability of participant to undergo serial non-invasive imaging.","ALL","12 Years",{"count":70,"type":71},740,"ESTIMATED","INTERVENTIONAL",[74],"PHASE2","Background:\n\nPeople with von Hippel-Lindau (VHL) can have problems with a variety of organs, such as the pancreas. The disease can cause tumors of the pancreas. This can result in life-threatening complications. Researchers want to learn more about these pancreatic tumors and how to better detect them. This may help them design better future treatment and care for people with VHL disease.\n\nObjective:\n\nTo better understand VHL disease that affects the pancreas and to test whether adding a certain type of scan (68-Gallium DOTATATE PET\u002FCT) can further detect tumors.\n\nEligibility:\n\nPeople ages 12 and older with VHL that causes tumors and cysts to grow in the pancreas\n\nDesign:\n\nParticipants will be screened with their medical records and imaging studies.\n\nParticipants will have an initial evaluation:\n\nParticipants will have their body examined by different doctors. This will depend on what types of symptoms they have.\n\nParticipants will have blood and urine tests\n\nParticipants will have images made of their body using one or more machines: They made have a CT or PET\u002FCT scan in which they lie on a table that moves through a big ring. They may have an MRI in which they lie on a table that moves into a big tube. They may have an ultrasound that uses a small stick that produces sound waves to look at the body.\n\nAfter the first visit, participants will be asked to return to the NIH. Some of the tests performed at the first visit will be repeated. Depending on their disease status, visits will be once a year or every 2 years for life.",[77,78,79],"VHL Pancreatic Neuroendocrine Tumors","Von Hippel-Lindau Disease","Neuroendocrine Tumors",[81,22,82,83,84],"Pancreatic tumors","MEN1 syndrome","NETest","PNET","2026-04-17",{"date":87,"type":88},"2026-04-20","ACTUAL",{"date":90,"type":88},"2020-06-02",{"date":92,"type":71},"2036-07-01",{"name":28,"class":6},1]