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The concentration must not exceed 1.2 mg\u002Fml.",[9],[29],"Taxol",{"type":18,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"Carboplatin","Neoadjuvant \u002F induction treatment:\n\nAtezolizumab Paclitaxel Carboplatin\\*\n\n\\*Infusion according to the standard of each center\n\nNeoadjuvant \u002F induction treatment 3 cycles will be administered prior to the assessment for surgery.\n\nRoute of administration Carboplatin: Intravenous infusion. Guidelines of Carboplatin administration: According to the standard of each center.",[9],[35],"Paraplatin",[37],{"name":38,"affiliation":39,"role":40},"Mariano Provencio, MD","President of Grupo Español de Cáncer de Pulmón","STUDY_CHAIR",[42],{"name":43,"role":44,"phone":45,"phoneExt":46,"email":47},"Eva Pereira","CONTACT","+34934302006",null,"secretaria@gecp.org",[49,67,81,93,103,113,126,140,153,166,180,195,208,222,235,249,262,275,288,302,317],{"facility":50,"status":51,"city":52,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Hospital General Universitario Dr. Balmis de Alicante","RECRUITING","Alicante","03010","Spain","ES",{"type":57,"coordinates":58},"Point",[59,60],-0.48149,38.34517,{"lat":60,"lon":59},[63,65],{"name":64,"role":44,"phone":46,"phoneExt":46,"email":46},"Bartomeu Massuti, MD",{"name":64,"role":66,"phone":46,"phoneExt":46,"email":46},"PRINCIPAL_INVESTIGATOR",{"facility":68,"status":51,"city":69,"state":70,"zip":71,"country":54,"countryCode":55,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"ICO Badalona, Hospital Germans Trias i Pujol","Badalona","Barcelona","08916",{"type":57,"coordinates":73},[74,75],2.24741,41.45004,{"lat":75,"lon":74},[78,80],{"name":79,"role":44,"phone":46,"phoneExt":46,"email":46},"Enric Carcereny, MD",{"name":79,"role":66,"phone":46,"phoneExt":46,"email":46},{"facility":82,"status":51,"city":70,"state":70,"zip":83,"country":54,"countryCode":55,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Hospital Universitari Vall d' Hebron","08035",{"type":57,"coordinates":85},[86,87],2.15899,41.38879,{"lat":87,"lon":86},[90,92],{"name":91,"role":44,"phone":46,"phoneExt":46,"email":46},"Alex Martínez, MD",{"name":91,"role":66,"phone":46,"phoneExt":46,"email":46},{"facility":94,"status":51,"city":70,"state":70,"zip":95,"country":54,"countryCode":55,"cosmosGeoPoint":96,"geoPoint":98,"contacts":99},"Hospital de la Santa Creu i Sant Pau","08041",{"type":57,"coordinates":97},[86,87],{"lat":87,"lon":86},[100,102],{"name":101,"role":44,"phone":46,"phoneExt":46,"email":46},"Sergio Martínez Recio, MD",{"name":101,"role":66,"phone":46,"phoneExt":46,"email":46},{"facility":104,"status":51,"city":70,"state":70,"zip":105,"country":54,"countryCode":55,"cosmosGeoPoint":106,"geoPoint":108,"contacts":109},"Hospital Parc Taulí","08208",{"type":57,"coordinates":107},[86,87],{"lat":87,"lon":86},[110,112],{"name":111,"role":44,"phone":46,"phoneExt":46,"email":46},"Laia Vilà, MD",{"name":111,"role":66,"phone":46,"phoneExt":46,"email":46},{"facility":114,"status":51,"city":115,"state":115,"zip":116,"country":54,"countryCode":55,"cosmosGeoPoint":117,"geoPoint":121,"contacts":122},"Hospital De Basurto","Bilbao","48013",{"type":57,"coordinates":118},[119,120],-2.92528,43.26271,{"lat":120,"lon":119},[123,125],{"name":124,"role":44,"phone":46,"phoneExt":46,"email":46},"Mª Ángeles Sala, MD",{"name":124,"role":66,"phone":46,"phoneExt":46,"email":46},{"facility":127,"status":51,"city":128,"state":129,"zip":130,"country":54,"countryCode":55,"cosmosGeoPoint":131,"geoPoint":135,"contacts":136},"Hospital Univ. De Jerez De La Frontera","Jerez de la Frontera","Cadiz","11407",{"type":57,"coordinates":132},[133,134],-6.13606,36.68645,{"lat":134,"lon":133},[137,139],{"name":138,"role":44,"phone":46,"phoneExt":46,"email":46},"Mª Angeles Moreno, MD",{"name":138,"role":66,"phone":46,"phoneExt":46,"email":46},{"facility":141,"status":51,"city":142,"state":142,"zip":143,"country":54,"countryCode":55,"cosmosGeoPoint":144,"geoPoint":148,"contacts":149},"ICO Girona, Hospital Josep Trueta","Girona","17007",{"type":57,"coordinates":145},[146,147],2.82493,41.98311,{"lat":147,"lon":146},[150,152],{"name":151,"role":44,"phone":46,"phoneExt":46,"email":46},"Elia Sais, MD",{"name":151,"role":66,"phone":46,"phoneExt":46,"email":46},{"facility":154,"status":51,"city":155,"state":155,"zip":156,"country":54,"countryCode":55,"cosmosGeoPoint":157,"geoPoint":161,"contacts":162},"Hospital Universitario Clinico San Cecilio","Granada","18007",{"type":57,"coordinates":158},[159,160],-3.60667,37.18817,{"lat":160,"lon":159},[163,165],{"name":164,"role":44,"phone":46,"phoneExt":46,"email":46},"Silvia Sequero López, MD",{"name":164,"role":66,"phone":46,"phoneExt":46,"email":46},{"facility":167,"status":51,"city":168,"state":169,"zip":170,"country":54,"countryCode":55,"cosmosGeoPoint":171,"geoPoint":175,"contacts":176},"Hospitalario Universitario A Coruña","A Coruña","La Coruña","15006",{"type":57,"coordinates":172},[173,174],-8.396,43.37135,{"lat":174,"lon":173},[177,179],{"name":178,"role":44,"phone":46,"phoneExt":46,"email":46},"Rosario García Campelo, MD",{"name":178,"role":66,"phone":46,"phoneExt":46,"email":46},{"facility":181,"status":51,"city":182,"state":183,"zip":184,"country":54,"countryCode":55,"cosmosGeoPoint":185,"geoPoint":189,"contacts":190},"Hospital Universitari de Gran Canària Doctor Negrín","Las Palmas de Gran Canaria","Las Palmas","35010",{"type":57,"coordinates":186},[187,188],-15.41573,28.10178,{"lat":188,"lon":187},[191,193],{"name":192,"role":44,"phone":46,"phoneExt":46,"email":46},"David Aguiar Bujanda, MD",{"name":194,"role":66,"phone":46,"phoneExt":46,"email":46},"David Aguiar Bujanda",{"facility":196,"status":51,"city":197,"state":197,"zip":198,"country":54,"countryCode":55,"cosmosGeoPoint":199,"geoPoint":203,"contacts":204},"Hospital Universitario Lucus Augusti","Lugo","27003",{"type":57,"coordinates":200},[201,202],-7.55602,43.00992,{"lat":202,"lon":201},[205,207],{"name":206,"role":44,"phone":46,"phoneExt":46,"email":46},"Begoña Campos, MD",{"name":206,"role":66,"phone":46,"phoneExt":46,"email":46},{"facility":209,"status":210,"city":211,"state":211,"zip":212,"country":54,"countryCode":55,"cosmosGeoPoint":213,"geoPoint":217,"contacts":218},"Hospital Universitario Fundación Jiménez 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Mallorca","07198",{"type":57,"coordinates":240},[241,242],2.65024,39.56939,{"lat":242,"lon":241},[245,247],{"name":246,"role":44,"phone":46,"phoneExt":46,"email":46},"Ester Gost, MD",{"name":248,"role":66,"phone":46,"phoneExt":46,"email":46},"Juan Coves Sarto, MD",{"facility":250,"status":51,"city":251,"state":251,"zip":252,"country":54,"countryCode":55,"cosmosGeoPoint":253,"geoPoint":257,"contacts":258},"Complejo Hospitalario de Navarra","Pamplona","31008",{"type":57,"coordinates":254},[255,256],-1.64323,42.81687,{"lat":256,"lon":255},[259,261],{"name":260,"role":44,"phone":46,"phoneExt":46,"email":46},"Maite Martínez, MD",{"name":260,"role":66,"phone":46,"phoneExt":46,"email":46},{"facility":263,"status":51,"city":264,"state":264,"zip":265,"country":54,"countryCode":55,"cosmosGeoPoint":266,"geoPoint":270,"contacts":271},"Hospital Universitario 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Rocio","Seville","Sevilla","41013",{"type":57,"coordinates":294},[295,296],-5.97317,37.38283,{"lat":296,"lon":295},[299,301],{"name":300,"role":44,"phone":46,"phoneExt":46,"email":46},"Reyes Bernabé, MD",{"name":300,"role":66,"phone":46,"phoneExt":46,"email":46},{"facility":303,"status":51,"city":304,"state":305,"zip":306,"country":54,"countryCode":55,"cosmosGeoPoint":307,"geoPoint":311,"contacts":312},"Hospital Universitari Sant Joan de Reus","Reus","Tarragona","43204",{"type":57,"coordinates":308},[309,310],1.10687,41.15612,{"lat":310,"lon":309},[313,315],{"name":314,"role":44,"phone":46,"phoneExt":46,"email":46},"Clara Lucía Gozalvez, MD",{"name":316,"role":66,"phone":46,"phoneExt":46,"email":46},"Clara Lucía Gozalvez, Md",{"facility":318,"status":51,"city":319,"state":319,"zip":320,"country":54,"countryCode":55,"cosmosGeoPoint":321,"geoPoint":325,"contacts":326},"Hospital General Universitario de Valencia","Valencia","46014",{"type":57,"coordinates":322},[323,324],-0.37966,39.47391,{"lat":324,"lon":323},[327,329],{"name":328,"role":44,"phone":46,"phoneExt":46,"email":46},"Paula Espinosa, MD",{"name":328,"role":66,"phone":46,"phoneExt":46,"email":46},{"type":331,"investigatorFullName":46,"investigatorTitle":46,"investigatorAffiliation":46,"oldNameTitle":46,"oldOrganization":46},"SPONSOR","100604740","phase-2-neoadjuvant-treatment-with-atezolizumab-and-atezolizumab-as-maintenance-for-the-treatment-of-stage-iii-non-small-cell-lung-cancer-nsclc-100604740",false,"NCT07153445","Neoadjuvant Treatment With Atezolizumab and Atezolizumab as Maintenance for the Treatment of Stage III Non Small-Cell Lung Cancer (NSCLC)","Phase II Clinical Trial of Chemotherapy + Atezolizumab for Stage IIIa and IIIb Non-small Cell Lung Cancer Followed by Atezolizumab as Adjuvant Treatment After Surgery and Atezolizumab as Maintenance Treatment for Non-resected Patients After Chemoradiotherapy","ATHENEA","Inclusion Criteria:\n\n* Previously untreated patients with histologically- or cytologically- documented Non Small-Cell Lung Cancer (NSCLC) who present stage IIIA - IIIB disease (according to 8th version of the International Association for the Study of Lung Cancer Staging Manual in Thoracic Oncology)\n* Confirm the absence of distant disease\n* ECOG (Performance status) 0-1\n* Adequate hematologic and organ function\n* All patients are notified of the investigational nature of this study and signed a written in-formed consent in accordance with institutional and national guidelines, including the Declaration of Helsinki prior to any trial-related intervention\n* Adequate lung function\n* Patients aged \\> 18 years\n* For female patients of childbearing potential, agreement (by patient and\u002For partner) to use a highly effective form(s) of contraception\n* For male patients with female partners of childbearing potential, agreement (by patient and\u002For partner) to use a highly effective form of contraception\n* Oral contraception should always be combined with an additional contraceptive method\n* Women who are not postmenopausal or surgically sterile must have a negative serum pregnancy test result within 8 days prior to initiation of study drug.\n* Patient capable of proper therapeutic compliance and accessible for correct follow-up\n\nExclusion Criteria:\n\n* Patients mutation or an amplification in the EGFRgene, ALK fusion oncogene.\n* Known STK-11 ligand alterations, MDM2 amplifications or ROS1 translocations.\n* Weight loss \\>10% within the previous 3 months.\n* Patients that receive previous treatment with antineoplasic drugs, chest radiotherapy, or previous surgery for lung cancer.\n* Malignancies other than Non Small-Cell Lung Cancer (NSCLC) within 3 years prior to enrolment\n* Pleural or pericardial effusion\n* Known hypersensitivity or allergy to atezolizumab formulation.\n* History of autoimmune disease or lung disease\n* Positive test for human immunodeficiency viruses (HIV)\n* Patients with active hepatitis B or hepatitis C or psitive for hepatitis C virus.\n* Active tuberculosis.\n* Symptomatic neuropathy grade \\> 1 according to Common Terminology Criteria for Adverse Events (CTCAE) v5.0\n* Severe infections within 4 weeks prior to be included in the study","ALL","18 Years",{"count":343,"type":344},97,"ESTIMATED","INTERVENTIONAL",[347],"PHASE2","This is an open-label, phase II, multi-centre clinical trial. 97 Patients with stage IIIA and IIIB non-small cell lung cancer will be enrolled.\n\nThe treatment is Atezolizumab + Paclitaxel + Carboplatin 3 cycles as neoadjuvant\u002Finduction treatment. After the induction treatment every patient will be evaluated by a multidisciplinary team in each participant hospital to decide if the patient is candidate for surgery or not.\n\nDepending on the decision each patient will be treated in a different way. The primary objective is to evaluate the Progression free survival (PFS). The total trial duration will be 10 years approximately. Patient accrual is expected to be completed within 2 years. Two years of treatment, 5 years of follow up, and 4-6 months of close-out.",[350,351,352],"Non Small Cell Lung Cancer","Stage IIIA Lung Cancer","Stage IIIB Lung Cancer",[354,19,355,356],"Non small cell lung cancer","Non-resected lung cancer","Adjuvant treatment","2025-11-17",{"date":359,"type":360},"2025-11-19","ACTUAL",{"date":362,"type":360},"2025-07-08",{"date":364,"type":344},"2035-05-02",{"name":5,"class":6},21]