[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100581861":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":46,"centralContacts":51,"locations":61,"responsibleParty":406,"collaborators":56,"id":408,"slug":409,"hasResults":410,"nctId":411,"briefTitle":412,"officialTitle":413,"acronym":414,"eligibilityCriteria":415,"healthyVolunteers":410,"sex":416,"minAge":417,"maxAge":418,"enrollmentInfo":419,"targetDuration":56,"studyType":422,"phases":423,"briefSummary":426,"conditions":427,"keywords":431,"overallStatus":381,"whyStopped":56,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":435,"startDateStruct":438,"completionDateStruct":440,"leadSponsor":442,"locationsCount":443},{"fullName":5,"class":6},"Institute of Hematology & Blood Diseases Hospital, China","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"(near)ETP-ALL","EXPERIMENTAL","All T-ALL patients will receive 8 mg\u002Fm2\u002Fday dexamethasone in induction therapy. For all ETP\u002Fnear-ETP T-ALL patients, venetoclax will replace daunorubicin in induction therapy. CAT will replace CAT+ during early intensification. Venetoclax will replace daunorubicin in interim therapy 2 and 4. In maintenance therapy 2, the CTX+Ara-C treatment cycles are reduced to 5, in order to minimize the impact of alkylating agents on fertility.",[13],"Drug: Venetoclax",{"label":15,"type":10,"description":16,"interventionNames":17},"nonETP-TALL-Das Group","All T-ALL patients will receive 8 mg\u002Fm2\u002Fday dexamethasone in induction therapy. All non-ETP T-ALL patients will receive dasatinib after initial window phase in induction therapy. For non-ETP T-ALL patients with MRD \\\u003C0.01% on day 46, CAT will replace CAT+ during early intensification, and patients will be continuously subjected to dasatinib combined with chemotherapy during early intensification, interim tharapy, reinduction therapy and maintenance therapy. In maintenance therapy 2, the CTX+Ara-C treatment cycles are reduced to 5, in order to minimize the impact of alkylating agents on fertility.",[18],"Drug: Dasatinib",{"label":20,"type":10,"description":21,"interventionNames":22},"nonETP-TALL-HHT Group","All T-ALL patients will receive 8 mg\u002Fm2\u002Fday dexamethasone in induction therapy. All non-ETP T-ALL patients will receive dasatinib after initial window phase in induction therapy. For non-ETP T-ALL patients with MRD ≥0.01% on day 46，CAT+ will be replaced with randomized doses of homoharringtonine (HHT) during early intensification, and HHT will be administrated during reinduction therapy. In maintenance therapy 2, the CTX+Ara-C treatment cycles are reduced to 5, in order to minimize the impact of alkylating agents on fertility.",[23],"Drug: homoharringtonine",[25,38,42],{"type":26,"name":27,"description":11,"armGroupLabels":28,"otherNames":29},"DRUG","Venetoclax",[9],[30,31,32,33,34,35,36,37],"Asparaginase","Vincristine","Cyclophosphomide","Cytarabine","6-MP","Methotrexate","Daunorubicin","Dexamethasone",{"type":26,"name":39,"description":16,"armGroupLabels":40,"otherNames":41},"Dasatinib",[15],[37,30,31,36,32,33,34,35],{"type":26,"name":43,"description":21,"armGroupLabels":44,"otherNames":45},"homoharringtonine",[20],[37,30,31,36,32,33,34,35],[47],{"name":48,"affiliation":49,"role":50},"Xiaofan Zhu, MD","Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC","PRINCIPAL_INVESTIGATOR",[52,58],{"name":53,"role":54,"phone":55,"phoneExt":56,"email":57},"Jingliao Zhang, MD","CONTACT","+86 22 23909196",null,"zhangjingliao@ihcams.ac.cn",{"name":48,"role":54,"phone":59,"phoneExt":56,"email":60},"+ 86 22 23909001","xfzhu@ihcams.ac.cn",[62,80,89,103,117,131,141,155,169,183,193,203,217,227,237,251,264,278,292,305,319,329,339,353,366,380,392],{"facility":63,"status":64,"city":65,"state":66,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":74,"contacts":75},"Anhui Medical University Second Affiliated Hospital","NOT_YET_RECRUITING","Hefei","Anhui","China","CN",{"type":70,"coordinates":71},"Point",[72,73],117.28083,31.86389,{"lat":73,"lon":72},[76],{"name":77,"role":54,"phone":78,"phoneExt":56,"email":79},"Ningling Wang, MD","0551-63869302","zwnltt@126.com",{"facility":81,"status":64,"city":65,"state":66,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":82,"geoPoint":84,"contacts":85},"Anhui Provincial Children's Hospital",{"type":70,"coordinates":83},[72,73],{"lat":73,"lon":72},[86],{"name":87,"role":54,"phone":88,"phoneExt":56,"email":56},"Xuhan Zhang, 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Women and Children's Medical Center","Guangzhou","Guangdong",{"type":70,"coordinates":122},[123,124],113.25,23.11667,{"lat":124,"lon":123},[127],{"name":128,"role":54,"phone":129,"phoneExt":56,"email":130},"Hua Jiang, MD","020-81886332","jiang_hua18@sina.cn",{"facility":132,"status":64,"city":119,"state":120,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":133,"geoPoint":135,"contacts":136},"Nanfang Hospital, Southern Medical University",{"type":70,"coordinates":134},[123,124],{"lat":124,"lon":123},[137],{"name":138,"role":54,"phone":139,"phoneExt":56,"email":140},"Xuedong Wu, MD","020-61641114","xuedongwu@163.com",{"facility":142,"status":64,"city":143,"state":144,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":145,"geoPoint":149,"contacts":150},"The People's Hospital of Guangxi Zhuang Autonomous Region","Nanning","Guangxi",{"type":70,"coordinates":146},[147,148],108.31667,22.81667,{"lat":148,"lon":147},[151],{"name":152,"role":54,"phone":153,"phoneExt":56,"email":154},"Yan Dai, MD","0771-2635268","3677458@qq.com",{"facility":156,"status":64,"city":157,"state":158,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"The Affiliated Hospital of Guizhou Medical University","Guiyang","Guizhou",{"type":70,"coordinates":160},[161,162],106.71667,26.58333,{"lat":162,"lon":161},[165],{"name":166,"role":54,"phone":167,"phoneExt":56,"email":168},"Jiao Jin, MD","0851-86772025","jinjiao999@gmc.edu.cn",{"facility":170,"status":64,"city":171,"state":172,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":173,"geoPoint":177,"contacts":178},"Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology","Wuhan","Hubei",{"type":70,"coordinates":174},[175,176],114.26667,30.58333,{"lat":176,"lon":175},[179],{"name":180,"role":54,"phone":181,"phoneExt":56,"email":182},"Aiguo Liu, PhD","027-83663131","aiguoliu309@163.com",{"facility":184,"status":64,"city":171,"state":172,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":185,"geoPoint":187,"contacts":188},"Union Hospital of Tongji Medical College, Huazhong University of Science and Technology",{"type":70,"coordinates":186},[175,176],{"lat":176,"lon":175},[189],{"name":190,"role":54,"phone":191,"phoneExt":56,"email":192},"Xiaoyan Wu, PhD","027-85726114","xiaoyanw8016@163.com",{"facility":194,"status":64,"city":171,"state":172,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":195,"geoPoint":197,"contacts":198},"Wuhan Children's Hospital",{"type":70,"coordinates":196},[175,176],{"lat":176,"lon":175},[199],{"name":200,"role":54,"phone":201,"phoneExt":56,"email":202},"Hao Xiong, MD","13006107360","22587481@qq.com",{"facility":204,"status":64,"city":205,"state":206,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":207,"geoPoint":211,"contacts":212},"Hunan Children's Hospital","Changsha","Hunan",{"type":70,"coordinates":208},[209,210],112.97087,28.19874,{"lat":210,"lon":209},[213],{"name":214,"role":54,"phone":215,"phoneExt":56,"email":216},"Wenyong Kuang, PhD","0731-85356114","kathy5460@sina.com",{"facility":218,"status":64,"city":205,"state":206,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":219,"geoPoint":221,"contacts":222},"The Third Xiangya Hospital of the Central South University",{"type":70,"coordinates":220},[209,210],{"lat":210,"lon":209},[223],{"name":224,"role":54,"phone":225,"phoneExt":56,"email":226},"Minghua Yang, MD","0731-88618576","yangminghua@csu.edu.cn",{"facility":228,"status":64,"city":205,"state":206,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":229,"geoPoint":231,"contacts":232},"Xiangya Hospital Central South University",{"type":70,"coordinates":230},[209,210],{"lat":210,"lon":209},[233],{"name":234,"role":54,"phone":235,"phoneExt":56,"email":236},"Liangchun Yang, MD","0731-89753999","yangliangchung@163.com",{"facility":238,"status":64,"city":239,"state":240,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":241,"geoPoint":245,"contacts":246},"Nanjing Children's Hospital Affiliated to Nanjing Medical University","Nanjin","Jiangsu",{"type":70,"coordinates":242},[243,244],121.74055,31.75772,{"lat":244,"lon":243},[247],{"name":248,"role":54,"phone":249,"phoneExt":56,"email":250},"Yongjun Fang, MD","025-83117500","fyj322@189.cn",{"facility":252,"status":64,"city":253,"state":240,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":254,"geoPoint":258,"contacts":259},"Children's Hospital of Soochow University","Suzhou",{"type":70,"coordinates":255},[256,257],120.59538,31.30408,{"lat":257,"lon":256},[260],{"name":261,"role":54,"phone":262,"phoneExt":56,"email":263},"Shaoyan Hu, MD","0512-80695102","hsyl39@126.com",{"facility":265,"status":64,"city":266,"state":267,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":268,"geoPoint":272,"contacts":273},"Jiangxi Provincial Children's Hospital","Nanchang","Jiangxi",{"type":70,"coordinates":269},[270,271],115.85306,28.68396,{"lat":271,"lon":270},[274],{"name":275,"role":54,"phone":276,"phoneExt":56,"email":277},"Fei He, MD","0791-86802382","hefei1944@163.com",{"facility":279,"status":64,"city":280,"state":281,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":282,"geoPoint":286,"contacts":287},"Qilu Hospital of Shandong University","Jinan","Shandong",{"type":70,"coordinates":283},[284,285],116.99722,36.66833,{"lat":285,"lon":284},[288],{"name":289,"role":54,"phone":290,"phoneExt":56,"email":291},"Xiuli Ju, MD","0531-82169114","shellysdcn@hotmail.com",{"facility":293,"status":64,"city":294,"state":281,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":295,"geoPoint":299,"contacts":300},"Affiliated Hospital of Qingdao University","Qingdao",{"type":70,"coordinates":296},[297,298],120.38042,36.06488,{"lat":298,"lon":297},[301],{"name":302,"role":54,"phone":303,"phoneExt":56,"email":304},"Lingzhen Wang, MD","0532-96166","hopewang2006@163.com",{"facility":306,"status":64,"city":307,"state":308,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":309,"geoPoint":313,"contacts":314},"Children's Hospital of Fudan University","Shanghai","Shanghai Municipality",{"type":70,"coordinates":310},[311,312],121.45806,31.22222,{"lat":312,"lon":311},[315],{"name":316,"role":54,"phone":317,"phoneExt":56,"email":318},"Xiaowen Zhai, MD","021-64931990","zhaixiaowendy@163.com",{"facility":320,"status":64,"city":307,"state":308,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":321,"geoPoint":323,"contacts":324},"Shanghai Children's Hospital",{"type":70,"coordinates":322},[311,312],{"lat":312,"lon":311},[325],{"name":326,"role":54,"phone":327,"phoneExt":56,"email":328},"Hui Jiang, MD","021-62474880","jhui0111@126.com",{"facility":330,"status":64,"city":307,"state":308,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":331,"geoPoint":333,"contacts":334},"Shanghai Children's Medical Cener, Shanghai Jiao Tong University School of Medicine",{"type":70,"coordinates":332},[311,312],{"lat":312,"lon":311},[335],{"name":336,"role":54,"phone":337,"phoneExt":56,"email":338},"Shuhong Shen, MD","021-3862616","shenshuhong@scmc.com.cn",{"facility":340,"status":64,"city":341,"state":342,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":343,"geoPoint":347,"contacts":348},"Xi'an Northwest Women and Children Hospital","Xi’an","Shanxi",{"type":70,"coordinates":344},[345,346],113.52486,35.99785,{"lat":346,"lon":345},[349],{"name":350,"role":54,"phone":351,"phoneExt":56,"email":352},"Jian Zhang, MD","029-89550001","kailipan@fmmu.edu.cn",{"facility":354,"status":64,"city":355,"state":355,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":356,"geoPoint":360,"contacts":361},"Shenzhen Children's Hospital","Shenzhen",{"type":70,"coordinates":357},[358,359],114.0683,22.54554,{"lat":359,"lon":358},[362],{"name":363,"role":54,"phone":364,"phoneExt":56,"email":365},"Sixi Liu, MD","83936101","tiger647@126.com",{"facility":367,"status":64,"city":368,"state":369,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":370,"geoPoint":374,"contacts":375},"West China Second University Hospital","Chengdu","Sichuan",{"type":70,"coordinates":371},[372,373],104.06667,30.66667,{"lat":373,"lon":372},[376],{"name":377,"role":54,"phone":378,"phoneExt":56,"email":379},"Ju Gao, MD","028-88570307","gaoju651220@126.com",{"facility":49,"status":381,"city":382,"state":383,"zip":56,"country":67,"countryCode":68,"cosmosGeoPoint":384,"geoPoint":388,"contacts":389},"RECRUITING","Tianjin","Tianjin Municipality",{"type":70,"coordinates":385},[386,387],117.17667,39.14222,{"lat":387,"lon":386},[390],{"name":48,"role":54,"phone":391,"phoneExt":56,"email":60},"+86 022 23909001",{"facility":393,"status":64,"city":394,"state":394,"zip":56,"country":394,"countryCode":395,"cosmosGeoPoint":396,"geoPoint":400,"contacts":401},"Hong Kong Children's Hospital","Hong Kong","HK",{"type":70,"coordinates":397},[398,399],114.17469,22.27832,{"lat":399,"lon":398},[402],{"name":403,"role":54,"phone":404,"phoneExt":56,"email":405},"Chi-kong Li, MD","(852) 3505-2849","ckli@cuhk.edu.hk",{"type":407,"investigatorFullName":56,"investigatorTitle":56,"investigatorAffiliation":56,"oldNameTitle":56,"oldOrganization":56},"SPONSOR","100581861","phase-2-newly-diagnosed-pediatric-t-cell-all-protocol-100581861",false,"NCT06855810","Newly-diagnosed Pediatric T-cell ALL Protocol","Chinese Children's Cancer Group T-cell Acute Lymphoblastic Leukemia -2025 Project","CCCG-TALL-2025","Inclusion Criteria:\n\n1. Age older than 1 month to younger than 18 years.\n2. Diagnosis of acute lymphoblastic leukemia by bone marrow morphology.\n3. Diagnosis of T-ALL by immunophenotyping.\n\nExclusion Criteria:\n\n1. B-ALL\n2. AML\n3. Acute leukemias of ambiguous lineage diagnosed according to WHO or EGIL criteria.\n4. ALL evolved from chronic myeloid leukemia (CML).\n5. Down's syndrome, or major congenital or hereditary disease with organ dysfunction\n6. Secondary leukemia\n7. Known underlying congenital immunodeficiency or metabolic disease\n8. Congenital heart disease with cardiac insufficiency.\n9. Treated with glucocorticoids for ≥14 days, or ABL kinase inhibitors for \\> 7 days within one month before enrollment, or any chemotherapy or radiotherapy within 3 months before enrollment (except for emergency radiotherapy to relieve airway compression)\n10. Any significant comorbidities or psychiatric disorders that may impact patient safety, compliance, informed consent, study participation, follow-up, or the interpretation of study results. In such cases, all participating sites must report directly to the PI to determine whether the patient meets exclusion criteria.\n11. Severe malnutrition, active infections, heart failure, or chemotherapy intolerance.","ALL","1 Month","18 Years",{"count":420,"type":421},610,"ESTIMATED","INTERVENTIONAL",[424,425],"PHASE2","PHASE3","This is a prospective, multicenter study conducted within the Chinese Children's Cancer Group (CCCG). The study aims to evaluate whether the addition of three novel agents, dasatinib, venetoclax and homoharringtonine, can improve the minimal residual disease (MRD)-negative remission rate, enhance event-free survival (EFS), and reduce the cumulative incidence of relapse (CIR) in pediatric patients with newly diagnosed T-cell acute lymphoblastic leukemia (T-ALL).",[428,429,430],"Acute Lymphoblastic Leukemia","Childhood Leukemia, Acute Lymphoblastic","T Cell Acute Lymphoblastic Leukemia\u002FLymphoblastic Lymphoma",[432,433,43],"dasatinib","venetoclax","2025-08-23",{"date":436,"type":437},"2025-08-26","ACTUAL",{"date":439,"type":437},"2025-03-11",{"date":441,"type":421},"2031-06",{"name":5,"class":6},27]