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Newly diagnosed retinoblastoma (RB).\n2. Retinoblastoma with at least one eye eligible for conservative management.\n3. Patients likely to be compliant with the study requirements and visits, including late follow-up.\n4. Patients not previously treated with chemotherapy or radiotherapy for this or any other cancer.\n5. Patients with no contraindication to the proposed treatments.\n6. Informed consent signed by parents or legal representative.\n7. French Social Security System coverage.\n\nStudy 1 inclusion criteria:\n\n8.1. Children aged from 6 months to 6 years. 9. Retinoblastoma in at least one eye, deemed manageable with IAC in one side and without IV chemotherapy:\n\n1. Unilateral Retinoblastoma classified as group B, C (if vitreous seeds \\\u003C 3 mm), D or E with no invasion of the anterior segment, and without massive tumor of more than 2\u002F3 of the eye, eligible for conservative management, or\n2. 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