[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100385190":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":56,"collaborators":25,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":25,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":25,"enrollmentInfo":68,"targetDuration":25,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University of Miami","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment Once Daily","EXPERIMENTAL","Participant receives 81 mg aspirin taken once daily beginning the night before surgery and up to 28 days post surgery.",[13],"Drug: Aspirin",{"label":15,"type":16,"description":17,"interventionNames":18},"Treatment Twice Daily","ACTIVE_COMPARATOR","Participant receives 81 mg aspirin taken twice daily (one in the morning and one at night) beginning at the night before surgery and up to 28 days post surgery.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Aspirin","Non-enteric coated 81 mg Aspirin tablet.",[9,15],null,[27],{"name":28,"affiliation":5,"role":29},"Victor Hernandez, MD","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Ramakanth Yakkanti, MD","CONTACT","502-689-3127","ramakanth.yakkanti@jhsmiami.org",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"University of Miami Hospital","RECRUITING","Miami","Florida","33136","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-80.19366,25.77427,{"lat":49,"lon":48},[52,55],{"name":53,"role":33,"phone":34,"phoneExt":25,"email":54},"Ramakanth Yakkanti","ramakanth.yakkanti1@jhsmiami.org",{"name":28,"role":29,"phone":25,"phoneExt":25,"email":25},{"type":29,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Victor Hugo Hernandez","Associate Professor","100385190","phase-2-optimal-dosing-for-low-dose-aspirin-chemoprophylaxis-for-vte-following-total-joint-arthroplasty-100385190",false,"NCT04295486","Optimal Dosing For Low-Dose Aspirin Chemoprophylaxis For VTE Following Total Joint Arthroplasty","Optimal Dosing For Low-Dose Aspirin Chemoprophylaxis For Venous Thromboembolism (VTE) Following Total Joint Arthroplasty - A Multi-center Prospective Randomized Control Trial.","Inclusion criteria:\n\n* \\> 18 years of age\n* Planning to undergo a primary total hip or knee arthroplasty\n\nExclusion Criteria:\n\n* High risk patients for VTE as defined by:\n\n  * History of venous thromboembolism\n  * Active malignancy\n  * Known pro thrombotic condition\n* BMI \\> 40\n* Patients requiring anticoagulation for pre-existing conditions\n* Patients with the contraindication for use of aspirin or nonsteroidal antiinflammatory drugs for reasons such as peptic ulcer disease, intolerance, others.\n* Patients not fluent in the language of the informed consent form\n* Prisoners\n* Pregnancy\n* Reported to have mental illness or belonging to a vulnerable population","ALL","19 Years",{"count":69,"type":70},5478,"ESTIMATED","INTERVENTIONAL",[73],"PHASE2","This research study is attempting to answer the question of whether 81 mg aspirin once daily is as effective as 81 mg aspirin twice daily in preventing blood clots after total joint replacement surgery.",[76],"Venous Thromboembolism",[78,79,80],"Chemoprophylaxis","Hip Surgery","Knee Surgery","2026-03-09",{"date":83,"type":84},"2026-03-11","ACTUAL",{"date":86,"type":84},"2021-03-01",{"date":88,"type":70},"2027-03-01",{"name":5,"class":6},1]