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Medical history or active clinically significant bleeding, lesions, or conditions (at the investigator's judgement) considered to be of significant risk for major bleeding.\n3. Severe, uncontrolled hypertension (systolic blood pressure ≥ 185 mmHg or diastolic blood pressure ≥ 110 mmHg) that cannot be controlled with antihypertensive therapy.\n4. Known bleeding diathesis (hereditary or acquired) or any significant coagulopathy. Specifically, platelet count \\\u003C 100,000\u002FμL, international normalized ratio \\> 1.7, aPTT \\> 40 seconds, or prothrombin time \\> 15 seconds.\n5. Major trauma, surgery, or invasive procedures.\n6. Pre-existing medical, neurological, or psychiatric disease that would confound the neurological or functional evaluations of this study.\n7. Pre-treatment blood glucose \\> 400 mg\u002FdL (22.20 mmol\u002FL) or Pre-treatment blood glucose \\\u003C 50 mg\u002FdL (2.78 mmol\u002FL) unless it is corrected prior to study treatment administration. 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