[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100546134":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":40,"locations":23,"responsibleParty":49,"collaborators":54,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":23,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":23,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":93,"whyStopped":23,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":23},{"fullName":5,"class":6},"Fudan University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"tislelizumab","EXPERIMENTAL","CRT followed by 4 cycles of tislelizumab plus CAPOX and clinical response assessment:\n\nparticipants with CR (cCR+ pCR confirmed by local resection of ncCR): another 4 cycles of tislelizumab plus CAPOX and 9 cycles of tislelizumab, then watch and wait.\n\nparticipants with non-CR: underwent TME",[13,14,15,16],"Radiation: Radiotherapy","Drug: Tislelizumab","Drug: Capecitabine","Drug: Oxaliplatin",[18,24,29,33,37],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"RADIATION","Radiotherapy","45-50.4Gy in 25-28 fractions to the pelvis on Days 1-5 every week.",[9],null,{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":23},"DRUG","Tislelizumab","200 mg IV on Day 1 of each 21-day cycle.",[9],{"type":25,"name":30,"description":31,"armGroupLabels":32,"otherNames":23},"Capecitabine","Capecitabine 1000 mg\u002Fm2 orally twice daily (bid) on Day 1 to 14 of each 21-day cycle in CAPOX regimen",[9],{"type":25,"name":34,"description":35,"armGroupLabels":36,"otherNames":23},"Oxaliplatin","130 mg\u002Fm2 IV on Day 1 of each 21-day cycle in CAPOX regimen",[9],{"type":25,"name":30,"description":38,"armGroupLabels":39,"otherNames":23},"825 mg\u002Fm2 orally twice daily (bid) 5 days\u002Fweek during radiotherapy.",[9],[41,46],{"name":42,"role":43,"phone":44,"phoneExt":23,"email":45},"Min Jian Xu, MD","CONTACT","86-21-64041990","xujmin@aliyun.com",{"name":47,"role":43,"phone":23,"phoneExt":23,"email":48},"Tao Wen Tang, MD","Tangwt1988@163.com",{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":53,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Xu jianmin","Chief Physician","Shanghai Zhongshan Hospital",[55,56,58,60,62,64,66],{"name":53,"class":6},{"name":57,"class":6},"Shanghai Changzheng Hospital",{"name":59,"class":6},"Huadong Hospital",{"name":61,"class":6},"RenJi Hospital",{"name":63,"class":6},"Hebei Medical University Fourth Hospital",{"name":65,"class":6},"First Hospital of China Medical University",{"name":67,"class":6},"Liaoning Cancer Hospital & Institute","100546134","phase-2-organ-preservation-with-tislelizumab-and-total-neoadjuvant-therapy-in-patients-with-low-rectal-cancer-relieve--01-study-100546134",false,"NCT06390982","Organ Preservation With Tislelizumab and Total Neoadjuvant Therapy in Patients With Low Rectal Cancer: RELIEVE -01 Study","A Single-arm, Multicenter, Phase II Clinical Study of Chemoradiotherapy Followed by Tislelizumab Combined With Chemotherapy for Organ Preservation in Resectable Low Rectal Cancer：the RELIEVE-01 Study","Inclusion Criteria:\n\n1. Able to provide written informed consent, understand and comply with the requirements and evaluation schedule\n2. ≥18, ≤75 years old\n3. Histologically confirmed rectal adenocarcinoma\n4. immunohistochemistry confirmed pMMR (positive for MLH1, MSH2, MSH6 and PMS2), or PCR \u002FNGS confirmed MSI-L or MSS\n5. The distance from the lower edge of the tumor to the anal verge is ≤5 cm through colonoscopy, digital anal examination or MRI\n6. clinical stage cT1-3N1M0 or cT2-3N0M0 (the 8th UICC\u002FAJCC; T and N is evaluated by MRI)\n7. Resectable primary tumor assessed by the Investigator\n8. Have not received any anti-tumor treatment for rectal cancer\n9. ECOG PS ≤ 1\n10. Adequate organ function\n11. Female subjects with the ability to become pregnant must have a serum pregnancy test with a negative result within 72 hours before the first dose, and be willing to use highly effective contraceptive methods during the trial and 120 days after the last dose. Male subjects whose partners are women of childbearing potential should be surgically sterilized or agree to use a highly effective method of contraception during the trial and for 120 days after the last dose.\n\nExclusion Criteria:\n\n1. Histologically confirmed poorly differentiated\u002Fundifferentiated adenocarcinoma, mucinous adenocarcinoma and signet ring cell carcinoma\n2. Have received any treatments for rectal cancer, or evidence of distant metastasis\n3. Presence of following high risk factors assessed by MRI: MRF +, EMVI+, cN2, Positive lateral lymph nodes, T3d\n4. Presence or in high risk of obstruction, perforation or bleeding;\n5. Not suitable for long-course radiotherapy\n6. Cannot tolerate surgery\n7. ≥2 colorectal cancer lesions at the same time\n8. Contraindications for MRI examination\n9. Other malignant tumors in the past or at the same time\n10. Have an active autoimmune disease requiring systemic therapy within the past 2 years\n11. HIV infection\n12. Untreated chronic hepatitis B or chronic hepatitis B virus (HBV) carriers (HBV DNA \\> 500 IU\u002FmL) or active HCV carriers with detectable HCV RNA;\n13. Hypersensitivity to any ingredient of tislelizumab, capecitabine, and oxaliplatin or to any component of the container\n14. Other conditions judged by the researcher that do not meet the enrollment requirements","ALL","18 Years","75 Years",{"count":79,"type":80},46,"ESTIMATED","INTERVENTIONAL",[83],"PHASE2","This is an open-label, multi-center, single-arm clinical study. All patients received concurrent chemoradiation therapy (CRT) followed by 4 cycles of tislelizumab combined with CAPOX, then underwent clinical response assessment. Patients who achieved CR (cCR+ pCR confirmed by local resection of ncCR) continue tislelizumab combined with CAPOX for another 4 cycles and tislelizumab for 9 cycles, then Watch and Wait. Patients who did not achieved CR underwent total mesorectal excision (TME).",[86,87],"RECTAL NEOPLASMS","Rectal Cancer",[9,89,90,91,92],"low rectal cancer","organ preservation","watch and wait","TNT","NOT_YET_RECRUITING","2024-04-26",{"date":96,"type":97},"2024-04-30","ACTUAL",{"date":99,"type":80},"2024-05",{"date":101,"type":80},"2028-12",{"name":5,"class":6}]