[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100568615":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":57,"collaborators":26,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":26,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":26,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":84,"overallStatus":87,"whyStopped":26,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Medical College of Wisconsin","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Use of oral quercetin to improve human microvascular function","EXPERIMENTAL","Quercetin is a non-FDA approved, over-the-counter supplement that has been shown to improve oxidative capacity in blood vessels.",[13],"Dietary Supplement: Quercetin (dietary supplement)",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","A placebo will be administered for 30 days followed by assessment of the subject's microvascular function.",[19],"Drug: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Quercetin (dietary supplement)","Quercetin will be provided to take one Quercetin per day for 30 days to look for differences in microvascular function.",[9],null,{"type":28,"name":15,"description":29,"armGroupLabels":30,"otherNames":26},"DRUG","Subjects randomized to receive placebo will be administered a standard placebo sugar pill.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Julia A Vogt","CONTACT","4149552348","jvogt@mcw.edu",[38],{"facility":39,"status":26,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Froedtert Hospital","Wauwatosa","Wisconsin","53226","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-88.00759,43.04946,{"lat":49,"lon":48},[52,54],{"name":53,"role":34,"phone":35,"phoneExt":26,"email":36},"Julia Vogt",{"name":55,"role":56,"phone":26,"phoneExt":26,"email":26},"Julie Freed, MD, PhD","PRINCIPAL_INVESTIGATOR",{"type":56,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Julie K. Freed","Executive Vice Chair","100568615","phase-2-palmitic-acid-and-human-microvascular-function-100568615",false,"NCT06683534","Palmitic Acid and Human Microvascular Function","Use of Quercetin to Increase Resiliency to Palmitic Acid in the Human Microvasculature","Inclusion Criteria:\n\n* Obesity (BMI\\>30)\n* Aged 18-40 years\n* English Speaking\n\nExclusion Criteria:\n\n* BMI\\>60\n* Resting SBP ≥180 mmHg or DBP ≥ 110mmHg\n* Pregnancy or breastfeeding.\n* Prior history of myocardial infarction\n* Diagnosis of more than 1 risk factor for coronary artery disease (active smoker, diabetes mellitus- type 1 or 2, congestive heart failure, hyperlipidemia, hypertension)\n* Active mouth sores that affect the buccal mucosa.","ALL","18 Years","40 Years",{"count":71,"type":72},40,"ESTIMATED","INTERVENTIONAL",[75],"PHASE2","The goal of this study is to learn how a supplement Quercetin can affect microvascular function.\n\nParticipants will:\n\n* give two blood draws of 5 mL each\n* have a camera placed under the tongue to take pictures of blood vessels\n* have 2 laser Doppler microdialysis catheters placed on the forearm to monitor blood vessels before and after local drug infusion\n\nResearchers will compare blood vessel function of those who take estrogen supplements to those who do not.",[78,79,80,81,82,83],"Microvascular Dysfunction","Microvasculature","Cardiovascular Diseases","Cardiovascular Diseases (CVD)","Microvascular Health","Obesity and Overweight",[85,86],"Obesity","Supplement","NOT_YET_RECRUITING","2026-04-28",{"date":90,"type":91},"2026-04-29","ACTUAL",{"date":93,"type":72},"2026-07",{"date":95,"type":72},"2030-12",{"name":5,"class":6},1]