[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641511":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":34,"locations":11,"responsibleParty":44,"collaborators":11,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":11,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":11,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":71,"whyStopped":11,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":77,"leadSponsor":79,"locationsCount":11},{"fullName":5,"class":6},"Sichuan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Fruquintinib + Sintilimab + SOX","EXPERIMENTAL",null,[13],"Drug: fruquintinib + sintilimab + SOX",{"label":15,"type":16,"description":11,"interventionNames":17},"Sintilimab + SOX","ACTIVE_COMPARATOR",[18],"Drug: Sinitilimab+SOX",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","fruquintinib + sintilimab + SOX","Fruquintinib, 4mg po d1-14 q3w, four 3-week cycles were administered; S-1 (administered orally twice daily on days 1-14 of each 21-day cycle, with the daily dose determined by body surface area: \\\u003C1.25 m², 80 mg\u002Fday; ≥1.25 to \\\u003C1.5 m², 100 mg\u002Fday; ≥1.5 m², 120 mg\u002Fday), four 3-week cycles were administered.\n\nOxaliplatin (130 mg\u002Fm², administered intravenously on day 1), four 3-week cycles were administered.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Sinitilimab+SOX","S-1 (administered orally twice daily on days 1-14 of each 21-day cycle, with the daily dose determined by body surface area: \\\u003C1.25 m², 80 mg\u002Fday; ≥1.25 to \\\u003C1.5 m², 100 mg\u002Fday; ≥1.5 m², 120 mg\u002Fday), four 3-week cycles were administered.\n\nOxaliplatin (130 mg\u002Fm², administered intravenously on day 1), four 3-week cycles were administered.",[15],[30],{"name":31,"affiliation":32,"role":33},"Hongfeng Gou, Ph.D","Gastric Cancer Center, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, Sichuan, China.","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":11,"email":39},"Hongfeng Gou, PhD","CONTACT","+86-18980602292","gouhongfeng1977@wchscu.cn",{"name":41,"role":37,"phone":42,"phoneExt":11,"email":43},"Wen Nie, Ph.D","+86-02885423297","wennie1228@gmail.com",{"type":33,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Bo Zhang, MD","Chief Physician","100641511","phase-2-perioperative-fruquintinib-combined-with-sintilimab-and-sox-for-locally-advanced-gastric-or-gej-adenocarcinoma-100641511",false,"NCT07658872","Perioperative Fruquintinib Combined With Sintilimab and SOX for Locally Advanced Gastric or GEJ Adenocarcinoma","Perioperative Fruquintinib Combined With Sintilimab and SOX Versus Sintilimab and SOX for Resectable Locally Advanced Gastric\u002FGastroesophageal Junction Adenocarcinoma：A Multicenter,Open-label, Randomized Controlled Phase II Clinical Study","Inclusion Criteria:\n\n1. Age 18-75 years.\n2. Histologically confirmed gastric or gastroesophageal junction (G\u002FGEJ) adenocarcinoma.\n3. Eastern Cooperative Oncology Group (ECOG) performance status 0-1.\n4. Clinically staged as T3-4a N0-3M0 by computed tomography (CT) or magnetic resonance imaging (MRI).\n5. Considered eligible for curative resection.\n6. No prior antitumor therapy for the current disease.\n7. Adequate organ function, including hepatic, renal, and bone marrow function, as per prespecified laboratory criteria.\n8. Expected survival of ≥6 months.\n\nExclusion Criteria:\n\n1. Known mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) tumor.\n2. Uncontrolled hypertension, defined as systolic blood pressure ≥140 mmHg and\u002For diastolic blood pressure ≥ 90 mmHg despite optimized antihypertensive therapy, or hypertension complicated by acute events (e.g., hypertensive crisis, hypertensive encephalopathy) that cannot be stably controlled.\n3. Tumor lesions with a bleeding tendency, including but not limited to: active ulcerative tumor lesions, hematemesis within 2 months prior to informed consent, high risk of major gastrointestinal bleeding as determined by the investigator.\n4. History of thromboembolic or arterial\u002Fvenous vascular events within 6 months prior to enrollment, such as cerebrovascular events (including transient ischemic attack), deep vein thrombosis, or pulmonary embolism.\n5. Gastrointestinal perforation or gastrointestinal obstruction within 6 months prior to enrollment.","ALL","18 Years","75 Years",{"count":58,"type":59},120,"ESTIMATED","INTERVENTIONAL",[62],"PHASE2","The purpose of this clinical trial is to evaluate whether perioperative fruquintinib combined with sintilimab and SOX is effective in treating locally advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma. The study will also assess the safety profile of this treatment regimen.\n\nPrimary Objective:\n\nTo determine whether perioperative fruquintinib combined with sintilimab and SOX improves the pathological complete response (pCR) rate compared with sintilimab plus SOX in patients with locally advanced gastric or GEJ adenocarcinoma.\n\nStudy Design:\n\nParticipants will be randomly assigned to receive either fruquintinib combined with sintilimab and SOX or sintilimab plus SOX to evaluate the potential added benefit of fruquintinib in this setting.\n\nParticipation Details:\n\nParticipants will receive the assigned treatment (fruquintinib combined with sintilimab and SOX or sintilimab plus SOX) every 21 days for approximately 3 months.\n\nThey will visit the clinic once every 3 weeks for evaluations, laboratory tests, and monitoring.\n\nParticipants will be asked to keep a daily diary to record any symptoms or side effects experienced during the study.",[65,66],"Gastric Adenocarcinoma","Esophagogastric Junction Adenocarcinoma",[68,69,70],"Gastric Cancer","neoadjuvant treatment","Fruquintinib","NOT_YET_RECRUITING","2026-06-15",{"date":74,"type":75},"2026-06-22","ACTUAL",{"date":72,"type":59},{"date":78,"type":59},"2028-04-06",{"name":5,"class":6}]