[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100525590":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":46,"locations":57,"responsibleParty":94,"collaborators":96,"id":102,"slug":103,"hasResults":104,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":104,"sex":110,"minAge":111,"maxAge":74,"enrollmentInfo":112,"targetDuration":74,"studyType":115,"phases":116,"briefSummary":118,"conditions":119,"keywords":74,"overallStatus":60,"whyStopped":74,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":132},{"fullName":5,"class":6},"University Health Network, Toronto","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention","EXPERIMENTAL","Preoperative Vitamin C capsules",[13],"Drug: Vitamin C",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Preoperative placebo capsules",[19],"Drug: Placebo",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Vitamin C","Drug: Patients in the intervention group will receive 2g Vitamin C orally within 4 hours of the start of the surgery followed by 500 mg of Vitamin C to be taken orally twice a day from post-op day1 to day 56.",[9],[27],"Ascorbic Acid",{"type":22,"name":15,"description":29,"armGroupLabels":30,"otherNames":31},"Drug: Patients in the placebo group will receive identical placebo capsules taken orally within 4 hours of the start of the surgery followed by placebo capsules taken orally twice a day from post-op day 1 to day 56.",[15],[32],"Lactose (Monohydrate)",[34,38,41,43],{"name":35,"affiliation":36,"role":37},"James Khan, MD","University Health Network; Department of Anesthesia and Pain Medicine","PRINCIPAL_INVESTIGATOR",{"name":39,"affiliation":40,"role":37},"Raman Mundi, MD","Holland Orthopedic and Arthritic Centre",{"name":42,"affiliation":40,"role":37},"Harman Chaudhry, MD",{"name":44,"affiliation":45,"role":37},"Jesse Wolfstadt, MD","Mount Sinai Hospital; Department of Surgery",[47,52],{"name":35,"role":48,"phone":49,"phoneExt":50,"email":51},"CONTACT","416-340-4800","3243","James.Khan@medportal.ca",{"name":53,"role":48,"phone":54,"phoneExt":55,"email":56},"Nour Ayach","(416) 340 4800","4221","Nour.Ayach@uhn.ca",[58,76,84],{"facility":59,"status":60,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":71,"contacts":72},"Sunnybrook - Holland Centre","RECRUITING","Toronto","Ontario","M4Y 1H1","Canada","CA",{"type":67,"coordinates":68},"Point",[69,70],-79.39864,43.70643,{"lat":70,"lon":69},[73],{"name":39,"role":48,"phone":74,"phoneExt":74,"email":75},null,"Raman.Mundi@medportal.ca",{"facility":77,"status":60,"city":61,"state":62,"zip":78,"country":64,"countryCode":65,"cosmosGeoPoint":79,"geoPoint":81,"contacts":82},"Mount Sinai Hospital","M5G 1X5",{"type":67,"coordinates":80},[69,70],{"lat":70,"lon":69},[83],{"name":35,"role":48,"phone":74,"phoneExt":74,"email":51},{"facility":85,"status":60,"city":61,"state":62,"zip":86,"country":64,"countryCode":65,"cosmosGeoPoint":87,"geoPoint":89,"contacts":90},"Toronto Western Hospital","M5T 2S8",{"type":67,"coordinates":88},[69,70],{"lat":70,"lon":69},[91],{"name":92,"role":48,"phone":74,"phoneExt":74,"email":93},"Anuj Bhatia, MD","Anuj.Bhatia@uhn.ca",{"type":95,"investigatorFullName":74,"investigatorTitle":74,"investigatorAffiliation":74,"oldNameTitle":74,"oldOrganization":74},"SPONSOR",[97,100],{"name":98,"class":99},"Canadian Institutes of Health Research (CIHR)","OTHER_GOV",{"name":101,"class":6},"The Arthritis Society, Canada","100525590","phase-2-perioperative-vitamin-c-to-reduce-persistent-pain-after-total-knee-arthroplasty-100525590",false,"NCT06123715","Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty","PeRiOperative VItamin C to Reduce perSistent paIn After tOtal kNee Arthroplasty (PROVISION): a Pilot Multicentre Randomized Controlled Trial","PROVISION","Inclusion Criteria:\n\n* Patients \\>18 years old\n* Undergoing a unilateral or bilateral primary total knee arthroplasty for advanced osteoarthritis of the knee\n\nExclusion Criteria:\n\n* TKA for infection (septic joint), fracture, ankylosing spondylitis, lupus, or psoriatic arthritis\n* History of kidney stones, acute or chronic renal failure, hemochromatosis, or glucose-6-phosphate deficiency\n* Unlikely to comply with follow-up (e.g., no fixed address, plans to move out of town)\n* Language difficulties that would impede valid completion of questionnaires\n* Planned staged bilateral TKA\n* Treating surgeon deems patient inappropriate for inclusion in trial\n* Any allergy or sensitivity to milk\n* Pregnant or planning to become pregnant during the study","ALL","18 Years",{"count":113,"type":114},400,"ESTIMATED","INTERVENTIONAL",[117],"PHASE2","Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total knee arthroplasty surgery.",[120,121,122],"Chronic Pain","Knee Pain Chronic","Post Operative Pain","2026-06-19",{"date":125,"type":126},"2026-06-23","ACTUAL",{"date":128,"type":126},"2024-04-16",{"date":130,"type":114},"2027-12-31",{"name":5,"class":6},3]