[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100296775":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":23,"centralContacts":27,"locations":34,"responsibleParty":51,"collaborators":53,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":32,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":32,"studyType":71,"phases":72,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":36,"whyStopped":32,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"University of Pennsylvania","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Positron Emission Tomography (PET\u002FCT) Imaging of Tau Pathology in Neurodegenerative Disease","EXPERIMENTAL","Individuals who have been diagnosed with FTD, PPA, CBD, PSP, MCI, AD, PCA, PD, PDD, DLB, MSA, ALS or FTD-ALS may participate in this study if they are 18 years of age or older; most participants will be receiving care at the clinical practices of the of the University of Pennsylvania and at Pennsylvania Hospital Department of Neurology. Healthy control subjects will also be recruited for this study.",[13],"Drug: 18F-AV-1451",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","18F-AV-1451","The experimental tracer used for this study is called 18F-AV-1451 is a specialized radioactive PET tracer used to detect the presence of tau proteins in the brain.\n\nParticipants will undergo a baseline 18F-AV-1451 brain scan. If funding is available, participants will be asked to return for one or more longitudinal visits, including a 18F-AV-1451 brain scan, every 9 to 18 months after the prior visit.\n\nThe 18F-AV-1451 PET\u002FCT scan will require up to 3 hours of time, including preparation. The scan will take place using PET\u002FCT scanners in the Perelman Center for Advanced Medicine or the Hospital of the University of Pennsylvania.",[9],[21,22],"formally known as 18F-T807","7-(6-[18F]fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole",[24],{"name":25,"affiliation":5,"role":26},"David Irwin, MD","PRINCIPAL_INVESTIGATOR",[28],{"name":29,"role":30,"phone":31,"phoneExt":32,"email":33},"Dahlia Kamel","CONTACT","215-662-6134",null,"kamel.dahlia@pennmedicine.upenn.edu",[35],{"facility":5,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Philadelphia","Pennsylvania","19104","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-75.16362,39.95238,{"lat":46,"lon":45},[49,50],{"name":29,"role":30,"phone":31,"phoneExt":32,"email":33},{"name":25,"role":26,"phone":32,"phoneExt":32,"email":32},{"type":52,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR",[54],{"name":55,"class":56},"Avid Radiopharmaceuticals","INDUSTRY","100296775","phase-2-pet-tau---neurodegenerative-disease-imaging-100296775",false,"NCT03143374","PET Tau - Neurodegenerative Disease Imaging","Positron Emission Tomography (PET) Imaging of Tau Pathology in Neurodegenerative Disease","INCLUSION CRITERIA FOR NEURODEGENERATIVE SUBJECTS\n\n1. Participants has been diagnosed with one of the following neurodegenerative diseases: FTD, PPA, CBD, PSP, MCI, AD, PCA, PD, PDD, DLB, MSA, ALS or FTD- ALS\n2. Participants will be 18 years of age or older\n3. Participants must be informed of the investigational nature of this study and provide written informed consent in accordance with institutional and federal guidelines prior to study-specific procedures. If the subject is unable to provide informed consent, the subject's legal representative may consent on behalf of the patient, but the patient will be asked to confirm assent.\n4. Participants must be willing and able to comply with scheduled visits and imaging procedures.\n5. Subject is concurrently enrolled in centers UNICORN(842873) protocol.\n\nINCLUSION CRITERIA FOR HEALTHY CONTROL SUBJECTS\n\n1. Participants will be 18 years of age or older.\n2. Participants must be informed of the investigational nature of this study and provide written informed consent in accordance with institutional and federal guidelines prior to study-specific procedures.\n3. Participants must be willing and able to comply with scheduled visits and imaging procedures.\n4. Subject is concurrently enrolled in centers UNICORN(842873) protocol\n\nEXCLUSION CRITERIA FOR ALL SUBJECTS\n\n1. Females who are pregnant or breast feeding at the time of the baseline PET\u002FCT scan will not be eligible for this study. A urine pregnancy test will be performed in women of child-bearing potential at screening and within 24 hours of any scheduled PET\u002FCT.\n2. Inability to tolerate or contraindication to imaging procedures in the opinion of an investigator or treating physician\n3. Any medical or psychological condition that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study\n4. The investigators may choose to exclude participants with clinically significant cardiovascular disease and\u002For documented abnormalities on ECG out of an abundance of caution.\n5. The investigators of UNICORN (IRB #842873) have determined the participant has evidence of structural abnormalities such as major stroke or mass on MRI that is likely to interfere with analysis of the PET scan.\n\nADDITIONAL EXCLUSION CRITERIA FOR HEALTHY CONTROL SUBJECTS\n\n1. Pre-existing psychiatric conditions (e.g., active depression, schizophrenia, or active anxiety) or neurological conditions (e.g., stroke, epilepsy, head trauma) per medical record review or self-report.\n2. Current use of psychoactive medications or substances per medical record review or self-report.",true,"ALL","18 Years","100 Years",{"count":69,"type":70},300,"ESTIMATED","INTERVENTIONAL",[73,74],"PHASE2","PHASE3","The purpose of this study is to measure the amount of a protein in the brain known as tau using an imaging procedure called Positron Emission Tomography (PET\u002FCT). Tau has been shown to build up in the brains of patients with injury to brain cells. This study looks at neurodegenerative diseases such as frontotemporal degeneration (FTD).",[77],"Neurodegenerative Disease",[77],"2025-10-10",{"date":81,"type":82},"2025-10-15","ACTUAL",{"date":84,"type":82},"2016-08-23",{"date":86,"type":70},"2030-09",{"name":5,"class":6},1]