[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605324":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":26,"responsibleParty":419,"collaborators":19,"id":421,"slug":422,"hasResults":423,"nctId":424,"briefTitle":425,"officialTitle":426,"acronym":427,"eligibilityCriteria":428,"healthyVolunteers":423,"sex":429,"minAge":430,"maxAge":431,"enrollmentInfo":432,"targetDuration":19,"studyType":435,"phases":436,"briefSummary":438,"conditions":439,"keywords":19,"overallStatus":29,"whyStopped":19,"lastUpdateSubmitDate":441,"lastUpdatePostDateStruct":442,"startDateStruct":445,"completionDateStruct":447,"leadSponsor":449,"locationsCount":450},{"fullName":5,"class":6},"Vertex Pharmaceuticals Incorporated","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"VX-407","EXPERIMENTAL","Participants will receive VX-407 for up to 52 weeks.",[13],"Drug: VX-407",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","Tablets for oral administration.",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Medical Information","CONTACT","617-341-6777","medicalinfo@vrtx.com",[27,41,50,60,69,79,88,98,108,117,127,137,147,157,167,173,183,192,202,211,217,227,237,246,256,266,276,286,294,304,314,322,330,340,348,358,368,376,385,393,398,403,411],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":19},"Alabama Kidney Research","RECRUITING","Alabaster","Alabama","35007","United States","US",{"type":36,"coordinates":37},"Point",[38,39],-86.81638,33.24428,{"lat":39,"lon":38},{"facility":42,"status":29,"city":43,"state":31,"zip":44,"country":33,"countryCode":34,"cosmosGeoPoint":45,"geoPoint":49,"contacts":19},"UAB Nephrology Research at CH19","Birmingham","35294",{"type":36,"coordinates":46},[47,48],-86.80249,33.52066,{"lat":48,"lon":47},{"facility":51,"status":29,"city":52,"state":53,"zip":54,"country":33,"countryCode":34,"cosmosGeoPoint":55,"geoPoint":59,"contacts":19},"Kaiser Permanente Los Angeles Medical Center","Los Angeles","California","90027",{"type":36,"coordinates":56},[57,58],-118.24368,34.05223,{"lat":58,"lon":57},{"facility":61,"status":29,"city":62,"state":53,"zip":63,"country":33,"countryCode":34,"cosmosGeoPoint":64,"geoPoint":68,"contacts":19},"UCSF Clinical Research Center at Parnassus","San Francisco","94143",{"type":36,"coordinates":65},[66,67],-122.41942,37.77493,{"lat":67,"lon":66},{"facility":70,"status":29,"city":71,"state":72,"zip":73,"country":33,"countryCode":34,"cosmosGeoPoint":74,"geoPoint":78,"contacts":19},"Nephrology & Hypertension Associates, PC","Middlebury","Connecticut","06762",{"type":36,"coordinates":75},[76,77],-73.12761,41.52787,{"lat":77,"lon":76},{"facility":80,"status":29,"city":81,"state":72,"zip":82,"country":33,"countryCode":34,"cosmosGeoPoint":83,"geoPoint":87,"contacts":19},"Yale University - Yale Nephrology Clinical Research Clinic","New Haven","06510",{"type":36,"coordinates":84},[85,86],-72.92816,41.30815,{"lat":86,"lon":85},{"facility":89,"status":29,"city":90,"state":91,"zip":92,"country":33,"countryCode":34,"cosmosGeoPoint":93,"geoPoint":97,"contacts":19},"Mayo Clinic - Jacksonville","Jacksonville","Florida","32224",{"type":36,"coordinates":94},[95,96],-81.65565,30.33218,{"lat":96,"lon":95},{"facility":99,"status":29,"city":100,"state":101,"zip":102,"country":33,"countryCode":34,"cosmosGeoPoint":103,"geoPoint":107,"contacts":19},"Emory School of Medicine - Renal Division","Atlanta","Georgia","30322",{"type":36,"coordinates":104},[105,106],-84.38798,33.749,{"lat":106,"lon":105},{"facility":109,"status":29,"city":110,"state":101,"zip":111,"country":33,"countryCode":34,"cosmosGeoPoint":112,"geoPoint":116,"contacts":19},"Renal Associates","Columbus","31904",{"type":36,"coordinates":113},[114,115],-84.98771,32.46098,{"lat":115,"lon":114},{"facility":118,"status":29,"city":119,"state":120,"zip":121,"country":33,"countryCode":34,"cosmosGeoPoint":122,"geoPoint":126,"contacts":19},"UChicago Medicine - Duchossois Center for Advanced Medicine - Nephrology","Chicago","Illinois","60637",{"type":36,"coordinates":123},[124,125],-87.65005,41.85003,{"lat":125,"lon":124},{"facility":128,"status":29,"city":129,"state":130,"zip":131,"country":33,"countryCode":34,"cosmosGeoPoint":132,"geoPoint":136,"contacts":19},"University of Iowa Health Care Medical Center- Nephrology","Iowa City","Iowa","52242",{"type":36,"coordinates":133},[134,135],-91.53017,41.66113,{"lat":135,"lon":134},{"facility":138,"status":29,"city":139,"state":140,"zip":141,"country":33,"countryCode":34,"cosmosGeoPoint":142,"geoPoint":146,"contacts":19},"Clinical & Translational Science Unit (CTSU) - Nephrology","Kansas City","Kansas","66160",{"type":36,"coordinates":143},[144,145],-94.62746,39.11417,{"lat":145,"lon":144},{"facility":148,"status":29,"city":149,"state":150,"zip":151,"country":33,"countryCode":34,"cosmosGeoPoint":152,"geoPoint":156,"contacts":19},"University of Maryland Medical Center - General Clinical Research Center","Baltimore","Maryland","21201",{"type":36,"coordinates":153},[154,155],-76.61219,39.29038,{"lat":155,"lon":154},{"facility":158,"status":29,"city":159,"state":160,"zip":161,"country":33,"countryCode":34,"cosmosGeoPoint":162,"geoPoint":166,"contacts":19},"Tufts Medical Center","Boston","Massachusetts","02111",{"type":36,"coordinates":163},[164,165],-71.05977,42.35843,{"lat":165,"lon":164},{"facility":168,"status":29,"city":159,"state":160,"zip":169,"country":33,"countryCode":34,"cosmosGeoPoint":170,"geoPoint":172,"contacts":19},"Beth Israel Deaconess Medical Center - Nephrology","02215",{"type":36,"coordinates":171},[164,165],{"lat":165,"lon":164},{"facility":174,"status":29,"city":175,"state":176,"zip":177,"country":33,"countryCode":34,"cosmosGeoPoint":178,"geoPoint":182,"contacts":19},"University of Minnesota -Clinics and Surgery Center (CSC) - Endocrine Clinic","Minneapolis","Minnesota","55455",{"type":36,"coordinates":179},[180,181],-93.26384,44.97997,{"lat":181,"lon":180},{"facility":184,"status":29,"city":185,"state":176,"zip":186,"country":33,"countryCode":34,"cosmosGeoPoint":187,"geoPoint":191,"contacts":19},"Mayo Clinic - Rochester","Rochester","55905",{"type":36,"coordinates":188},[189,190],-92.4699,44.02163,{"lat":190,"lon":189},{"facility":193,"status":29,"city":194,"state":195,"zip":196,"country":33,"countryCode":34,"cosmosGeoPoint":197,"geoPoint":201,"contacts":19},"DaVita Kidney Care - Las Vegas","Las Vegas","Nevada","89107",{"type":36,"coordinates":198},[199,200],-115.13722,36.17497,{"lat":200,"lon":199},{"facility":203,"status":29,"city":204,"state":204,"zip":205,"country":33,"countryCode":34,"cosmosGeoPoint":206,"geoPoint":210,"contacts":19},"The Rogosin Kidney Center","New York","10021",{"type":36,"coordinates":207},[208,209],-74.00597,40.71427,{"lat":209,"lon":208},{"facility":212,"status":29,"city":204,"state":204,"zip":213,"country":33,"countryCode":34,"cosmosGeoPoint":214,"geoPoint":216,"contacts":19},"General Nephrology Clinic - New York City","10032",{"type":36,"coordinates":215},[208,209],{"lat":209,"lon":208},{"facility":218,"status":29,"city":219,"state":220,"zip":221,"country":33,"countryCode":34,"cosmosGeoPoint":222,"geoPoint":226,"contacts":19},"Cleveland Clinic - Main Campus","Cleveland","Ohio","44195",{"type":36,"coordinates":223},[224,225],-81.69541,41.4995,{"lat":225,"lon":224},{"facility":228,"status":29,"city":229,"state":230,"zip":231,"country":33,"countryCode":34,"cosmosGeoPoint":232,"geoPoint":236,"contacts":19},"Geisinger Clinic","Danville","Pennsylvania","17822",{"type":36,"coordinates":233},[234,235],-76.61273,40.96342,{"lat":235,"lon":234},{"facility":238,"status":29,"city":239,"state":230,"zip":240,"country":33,"countryCode":34,"cosmosGeoPoint":241,"geoPoint":245,"contacts":19},"Perelman Center for Advanced Medicine - Nephrology","Philadelphia","19104",{"type":36,"coordinates":242},[243,244],-75.16362,39.95238,{"lat":244,"lon":243},{"facility":247,"status":29,"city":248,"state":249,"zip":250,"country":33,"countryCode":34,"cosmosGeoPoint":251,"geoPoint":255,"contacts":19},"Nephrology Clinical Trials Center","Nashville","Tennessee","37232",{"type":36,"coordinates":252},[253,254],-86.78444,36.16589,{"lat":254,"lon":253},{"facility":257,"status":29,"city":258,"state":259,"zip":260,"country":33,"countryCode":34,"cosmosGeoPoint":261,"geoPoint":265,"contacts":19},"UVM Medical Center - 1 South Prospect Street","Burlington","Vermont","05401",{"type":36,"coordinates":262},[263,264],-73.21207,44.47588,{"lat":264,"lon":263},{"facility":267,"status":29,"city":268,"state":269,"zip":270,"country":33,"countryCode":34,"cosmosGeoPoint":271,"geoPoint":275,"contacts":19},"Swedish Center for Comprehensive Care","Seattle","Washington","98104",{"type":36,"coordinates":272},[273,274],-122.33207,47.60621,{"lat":274,"lon":273},{"facility":277,"status":29,"city":278,"state":19,"zip":19,"country":279,"countryCode":280,"cosmosGeoPoint":281,"geoPoint":285,"contacts":19},"Universite Catholique de Louvain - Nephrology","Brussels","Belgium","BE",{"type":36,"coordinates":282},[283,284],4.34878,50.85045,{"lat":284,"lon":283},{"facility":287,"status":29,"city":288,"state":19,"zip":19,"country":279,"countryCode":280,"cosmosGeoPoint":289,"geoPoint":293,"contacts":19},"Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg - Nephrology","Leuven",{"type":36,"coordinates":290},[291,292],4.70093,50.87959,{"lat":292,"lon":291},{"facility":295,"status":29,"city":296,"state":19,"zip":19,"country":297,"countryCode":298,"cosmosGeoPoint":299,"geoPoint":303,"contacts":19},"McGill University Health Centre","Montreal","Canada","CA",{"type":36,"coordinates":300},[301,302],-73.58781,45.50884,{"lat":302,"lon":301},{"facility":305,"status":29,"city":306,"state":19,"zip":19,"country":307,"countryCode":308,"cosmosGeoPoint":309,"geoPoint":313,"contacts":19},"Centre Hospitalier Regional Universitaire (CHRU) Brest","Brest","France","FR",{"type":36,"coordinates":310},[311,312],-4.48628,48.39029,{"lat":312,"lon":311},{"facility":315,"status":29,"city":316,"state":19,"zip":19,"country":307,"countryCode":308,"cosmosGeoPoint":317,"geoPoint":321,"contacts":19},"Hopital Necker Enfants Malades - Neurology","Paris",{"type":36,"coordinates":318},[319,320],2.3488,48.85341,{"lat":320,"lon":319},{"facility":323,"status":29,"city":324,"state":19,"zip":19,"country":307,"countryCode":308,"cosmosGeoPoint":325,"geoPoint":329,"contacts":19},"Hopital Bretonneau","Tours",{"type":36,"coordinates":326},[327,328],0.70398,47.39484,{"lat":328,"lon":327},{"facility":331,"status":29,"city":332,"state":19,"zip":19,"country":333,"countryCode":334,"cosmosGeoPoint":335,"geoPoint":339,"contacts":19},"Charité - Klinik für Nephrologie und Intensivmedizin der","Berlin","Germany","DE",{"type":36,"coordinates":336},[337,338],13.41053,52.52437,{"lat":338,"lon":337},{"facility":341,"status":29,"city":342,"state":19,"zip":19,"country":333,"countryCode":334,"cosmosGeoPoint":343,"geoPoint":347,"contacts":19},"University Hospital Cologne (Koeln) - Nephrologie, Rheumatologie, Diabetologie und Allgemeine Innere Medizin","Cologne",{"type":36,"coordinates":344},[345,346],6.95,50.93333,{"lat":346,"lon":345},{"facility":349,"status":29,"city":350,"state":19,"zip":19,"country":351,"countryCode":352,"cosmosGeoPoint":353,"geoPoint":357,"contacts":19},"UMCG - Nephrology","Groningen","Netherlands","NL",{"type":36,"coordinates":354},[355,356],6.56667,53.21917,{"lat":356,"lon":355},{"facility":359,"status":29,"city":360,"state":19,"zip":19,"country":361,"countryCode":362,"cosmosGeoPoint":363,"geoPoint":367,"contacts":19},"Fundacio Puigvert","Barcelona","Spain","ES",{"type":36,"coordinates":364},[365,366],2.15899,41.38879,{"lat":366,"lon":365},{"facility":369,"status":29,"city":370,"state":19,"zip":19,"country":361,"countryCode":362,"cosmosGeoPoint":371,"geoPoint":375,"contacts":19},"Hospital Fundacion Jimenez Diaz","Madrid",{"type":36,"coordinates":372},[373,374],-3.70256,40.4165,{"lat":374,"lon":373},{"facility":377,"status":29,"city":43,"state":19,"zip":19,"country":378,"countryCode":379,"cosmosGeoPoint":380,"geoPoint":384,"contacts":19},"Queen Elizabeth Hospital Birmingham","United Kingdom","UK",{"type":36,"coordinates":381},[382,383],-1.89983,52.48142,{"lat":383,"lon":382},{"facility":386,"status":29,"city":387,"state":19,"zip":19,"country":378,"countryCode":379,"cosmosGeoPoint":388,"geoPoint":392,"contacts":19},"King's College Hospital - Pulmonology","London",{"type":36,"coordinates":389},[390,391],-0.12574,51.50853,{"lat":391,"lon":390},{"facility":394,"status":29,"city":387,"state":19,"zip":19,"country":378,"countryCode":379,"cosmosGeoPoint":395,"geoPoint":397,"contacts":19},"Royal Free Hospital - Nephrology",{"type":36,"coordinates":396},[390,391],{"lat":391,"lon":390},{"facility":399,"status":29,"city":387,"state":19,"zip":19,"country":378,"countryCode":379,"cosmosGeoPoint":400,"geoPoint":402,"contacts":19},"St George's Hospital London - Nephrology",{"type":36,"coordinates":401},[390,391],{"lat":391,"lon":390},{"facility":404,"status":29,"city":405,"state":19,"zip":19,"country":378,"countryCode":379,"cosmosGeoPoint":406,"geoPoint":410,"contacts":19},"Newcastle upon Tyne Hospitals NHS Foundation Trust - Freeman Hospital - Nephrology","Newcastle upon Tyne",{"type":36,"coordinates":407},[408,409],-1.61396,54.97328,{"lat":409,"lon":408},{"facility":412,"status":29,"city":413,"state":19,"zip":19,"country":378,"countryCode":379,"cosmosGeoPoint":414,"geoPoint":418,"contacts":19},"Northern General Hospital","Sheffield",{"type":36,"coordinates":415},[416,417],-1.4659,53.38297,{"lat":417,"lon":416},{"type":420,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100605324","phase-2-phase-2a-study-of-vx-407-in-participants-with-adpkd-who-have-a-subset-of-pkd1-gene-variants-aglow-100605324",false,"NCT07161037","Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW)","A Phase 2a, Open-label, Single-arm Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of VX-407 in Subjects With Autosomal Dominant Polycystic Kidney Disease Who Have a Subset of PKD1 Gene Variants","AGLOW","Key Inclusion Criteria:\n\n* A pre-existing diagnosis of ADPKD as defined in the protocol\n* Willing and able to comply with scheduled visits and other study procedures\n* Participants with ADPKD with Mayo imaging classification (MIC) status of 1B (with htTKV ≥250 mL\u002Fm), 1C, 1D, or 1E confirmed by abdominal MRI obtained during screening\n* Estimated glomerular filtration rate (eGFR) greater than or equal to (≥) 25 milliliter per minute (mL\u002Fmin)\u002F1.73 square meter (m\\^2)\n\nKey Exclusion Criteria:\n\n* History of kidney disease other than ADPKD that in the opinion of the investigator would independently impact the natural history of ADPKD\n* History of solid organ or bone marrow transplantation or nephrectomy\n* Ongoing renal replacement therapy or planning to start renal replacement therapy within 12 months of screening\n\nOther protocol defined Inclusion\u002FExclusion criteria will apply.","ALL","18 Years","65 Years",{"count":433,"type":434},24,"ESTIMATED","INTERVENTIONAL",[437],"PHASE2","The purpose of the study is to evaluate the effect of VX-407 on height-adjusted total kidney volume (htTKV), safety, tolerability, and pharmacokinetics (PK) of VX-407.",[440],"Autosomal Dominant Polycystic Kidney Disease (ADPKD)","2026-06-11",{"date":443,"type":444},"2026-06-15","ACTUAL",{"date":446,"type":444},"2025-11-19",{"date":448,"type":434},"2027-12-31",{"name":5,"class":6},43]