[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612621":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":22,"centralContacts":31,"locations":37,"responsibleParty":51,"collaborators":22,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":22,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":22,"enrollmentInfo":62,"targetDuration":22,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":39,"whyStopped":22,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"The First Affiliated Hospital of Soochow University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Pirtobrutinib, Lisaftoclax, and Rituximab","EXPERIMENTAL","R\u002FR DLBCL patients will receive PVR for a total of 2 treatment cycles (28 days per cycle) in the induction treatment. Patients with CR\u002FPR after two cycles recieve consolidation therapy : ASCT or CAR-T or PVR (R for 6 cycles, PV continued until disease progression or intolerable adverse reactions) or radiotherapy.The patient will be followed up for two years.",[13,14,15],"Drug: Pirtobrutinib","Drug: Lisaftoclax","Drug: Rituximab",[17,23,27],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"DRUG","Pirtobrutinib","200mg qd po",[9],null,{"type":18,"name":24,"description":25,"armGroupLabels":26,"otherNames":22},"Lisaftoclax","cycle 1: 200mg qd d1-7; 400mg qd d8-d28；Cycle 2: 400mg qd d1-d28 po",[9],{"type":18,"name":28,"description":29,"armGroupLabels":30,"otherNames":22},"Rituximab","375mg\u002Fm2 d1 intravenous drip",[9],[32],{"name":33,"role":34,"phone":35,"phoneExt":22,"email":36},"Changju Qu","CONTACT","67781865","qcj310@163.com",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":22},"RECRUITING","Suzhou","Jiangsu","215006","China","CN",{"type":46,"coordinates":47},"Point",[48,49],120.59538,31.30408,{"lat":49,"lon":48},{"type":52,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR","100612621","phase-2-pirtobrutinib-lisaftoclax-and-rituximab-in-the-treatment-of-rr-dlbcl-100612621",false,"NCT07255963","Pirtobrutinib, Lisaftoclax, and Rituximab in the Treatment of R\u002FR DLBCL","A Prospective Study of Pirtobrutinib, Lisaftoclax, and Rituximab in the Treatment of Relapsed or Refractory Diffuse Large B-Cell Lymphoma (R\u002FR DLBCL)","Inclusion Criteria:\n\n1. ≥18 years old.\n2. Capable of understanding and voluntarily signing written informed consent.\n3. ECOG performance 0 \\~ 3.\n4. Anticipated survival ≥3 months\n5. Histologically or cytologically confirmed DLBCL.\n6. PET-CT-defined measurable disease with a short axis diameter of ≥1.5 cm.\n7. Have received at least one prior line of systemic therapy for DLBCL.\n8. Resolution of any prior treatment-related non-hematologic toxicities to Grade ≤1 or baseline.\n9. Adequate Bone Marrow and Organ Function, defined as:\n\n   Bone Marrow Function: ANC≥1.5 × 10⁹\u002FL, Platelets ≥80 × 10⁹\u002FL, Hemoglobin ≥80 g\u002FL Hepatic Function: Total bilirubin ≤1.5 × ULN (≤3.0 × ULN if liver metastases present); AST\u002FSGOT and ALT\u002FSGPT ≤2.5 × ULN (≤5.0 × ULN if liver metastases present) Coagulation: INR and aPTT≤1.5 × ULN Renal Function: Serum creatinine ≤1.5 × ULN or estimated creatinine clearance (CrCl) ≥60 mL\u002Fmin;\n10. Subjects with childbearing or childbearing potential must be willing to practice birth control from the date of registration in this study to the follow-up period of the study.\n11. Able to swallow tablets\u002Fcapsules without difficulty.\n12. Adhere to scheduled visits, treatment plans, laboratory tests, and other study procedures.\n\nExclusion Criteria:\n\n1. Prior treatment failure or resistance to pirtobrutinib or BCL2 inhibitors.\n2. Prior Anticancer Therapy:Chemotherapy, radiotherapy, immunotherapy, or antibody-based anticancer therapy within the specified washout period.Traditional Chinese herbal medicine with antitumor indications.Small-molecule targeted therapy within 2 weeks before study treatment initiation. ADCs or cytotoxic therapy within 10 weeks before study treatment initiation.\n3. Participation in another investigational drug study within 4 weeks prior to the first dose of study treatment.\n4. Systemic corticosteroid therapy (\\>5 days within 14 days prior to treatment) at doses exceeding \\>10 mg\u002Fday dexamethasone (or equivalent) for CNS disease control.\n5. Requiring ongoing anticancer therapy.\n6. Uncontrolled or Severe Cardiovascular Disease,\n7. Active infection requiring IV antibiotics or systemic antimicrobial therapy.\n8. Active HBV\u002FHCV:Exceptions. Inactive HBsAg carriers, HBV patients with sustained viral suppression (HBV-DNA \\\u003C LLOD),HCV-cured patients are allowed.\n9. Clinically significant abnormalities affecting drug absorption or prior total gastrectomy\u002Fgastric banding.\n10. History of hemorrhagic diathesis or requirement for long-term oral anticoagulation.\n11. Prior allogeneic hematopoietic stem cell transplantation (HSCT) or planned allogeneic HSCT.\n12. Women who are pregnant or breastfeeding.\n13. Known allergy to the study drug or its excipients.\n14. Active psychiatric illness or history of alcohol\u002Fdrug abuse .\n15. Any uncontrolled illness, organ dysfunction, or medical condition that, in the investigator's judgment, jeopardizes patient safety or adherence to study procedures.\n16. Other conditions deemed inappropriate for study participation by the investigator.","ALL","18 Years",{"count":63,"type":64},29,"ESTIMATED","INTERVENTIONAL",[67],"PHASE2","This study aims to evaluate the efficacy of combining pirtobrutinib, lisaftoclax, and rituximab (PVR) in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who have received at least one prior line of systemic therapy and to explore a more effective treatment strategy for this patient population.",[70],"DLBCL - Diffuse Large B Cell Lymphoma",[72,24,73],"pirtobrutinib","DLBCL","2025-11-27",{"date":76,"type":77},"2025-12-01","ACTUAL",{"date":79,"type":64},"2025-11-30",{"date":81,"type":64},"2030-09-30",{"name":5,"class":6},1]