[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100297328":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":38,"centralContacts":43,"locations":50,"responsibleParty":460,"collaborators":464,"id":470,"slug":471,"hasResults":472,"nctId":473,"briefTitle":474,"officialTitle":475,"acronym":476,"eligibilityCriteria":477,"healthyVolunteers":472,"sex":478,"minAge":479,"maxAge":480,"enrollmentInfo":481,"targetDuration":48,"studyType":484,"phases":485,"briefSummary":488,"conditions":489,"keywords":491,"overallStatus":53,"whyStopped":48,"lastUpdateSubmitDate":497,"lastUpdatePostDateStruct":498,"startDateStruct":501,"completionDateStruct":503,"leadSponsor":505,"locationsCount":506},{"fullName":5,"class":6},"Cambridge University Hospitals NHS Foundation Trust","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Control","ACTIVE_COMPARATOR","4 cycles of: Paclitaxel 80mg\u002Fm2 Day 1, 8 \\& 15, every 3 weeks, Carboplatin area under the curve (AUC) 5 Day 1, every 3 weeks",[13],"Drug: Paclitaxel and Carboplatin",{"label":15,"type":16,"description":17,"interventionNames":18},"Research 1","EXPERIMENTAL","4 cycles of: Paclitaxel 80mg\u002Fm2 on Days 1, 8 \\& 15 every 3 weeks, Carboplatin AUC 5 Day 1, every 3 weeks, Olaparib oral 150mg twice daily, Day -2 to Day 10 every 3 weeks",[19,13],"Drug: Olaparib",{"label":21,"type":16,"description":22,"interventionNames":23},"Research 2","4 cycles of: Paclitaxel 80mg\u002Fm2 on Days 1, 8 \\& 15 every 3 weeks, Carboplatin AUC 5 Day 1, every 3 weeks, Olaparib oral 150mg twice daily, Day 3 to Day 14 every 3 weeks",[19,13],[25,32],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Olaparib","Patients will self-administer Olaparib by mouth. Olaparib tablets should be taken twice daily at the same time each day approximately 12 hours apart.",[15,21],[31],"Lynparza",{"type":26,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"Paclitaxel and Carboplatin","Paclitaxel I.V. 80mg\u002Fm2 in 0.9% sodium chloride 500ml or according to local practice, will be given over 60 minutes on days 1, 8 \\& 15, every 3 weeks for 4 cycles. Carboplatin I.V. AUC5 in 5% dextrose 500ml or according to local practice, over 30-60minutes on day 1 every 3 weeks for 4 cycles.",[9,15,21],[37],"Taxol and Paraplatin",[39],{"name":40,"affiliation":41,"role":42},"Jean Abraham","The University of Cambridge, Department of Oncology","PRINCIPAL_INVESTIGATOR",[44],{"name":45,"role":46,"phone":47,"phoneExt":48,"email":49},"CCTC A Cambridge Cancer Trials Centre","CONTACT","+44 (0)1223 348071",null,"cuh.partner@nhs.net",[51,70,86,101,116,130,144,157,171,185,199,213,227,241,253,265,279,291,305,316,328,342,356,370,382,395,408,422,434,447],{"facility":52,"status":53,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Cambridge University Hospitals NHS Foundation Trust & the University of Cambridge","RECRUITING","Cambridge","Cambridgeshire","CB2 0QQ","United Kingdom","UK",{"type":60,"coordinates":61},"Point",[62,63],0.11667,52.2,{"lat":63,"lon":62},[66,69],{"name":67,"role":46,"phone":68,"phoneExt":48,"email":48},"CCTC Cambridge Cancer Trials Centre","+44(0) 1223 348071",{"name":40,"role":42,"phone":48,"phoneExt":48,"email":48},{"facility":71,"status":53,"city":72,"state":73,"zip":74,"country":57,"countryCode":58,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"Queen's Hospital","Burton-on-Trent","Derby","De13 ORB",{"type":60,"coordinates":76},[77,78],-1.64263,52.80728,{"lat":78,"lon":77},[81,84],{"name":82,"role":46,"phone":83,"phoneExt":48,"email":48},"First Contact","01283 511511",{"name":85,"role":42,"phone":48,"phoneExt":48,"email":48},"Mojca Persic",{"facility":87,"status":53,"city":88,"state":89,"zip":90,"country":57,"countryCode":58,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"The Christie","Manchester","Lancs","M20 4GJ",{"type":60,"coordinates":92},[93,94],-2.23743,53.48095,{"lat":94,"lon":93},[97,99],{"name":82,"role":46,"phone":98,"phoneExt":48,"email":48},"0161 446 3000",{"name":100,"role":42,"phone":48,"phoneExt":48,"email":48},"Anne Armstrong",{"facility":102,"status":53,"city":103,"state":104,"zip":105,"country":57,"countryCode":58,"cosmosGeoPoint":106,"geoPoint":110,"contacts":111},"Pinderfields General Hospital","Wakefield","Yorkshire","WF1 4DG",{"type":60,"coordinates":107},[108,109],-1.49768,53.68331,{"lat":109,"lon":108},[112,114],{"name":82,"role":46,"phone":113,"phoneExt":48,"email":48},"01924 542486",{"name":115,"role":42,"phone":48,"phoneExt":48,"email":48},"Sreedevi Kumar",{"facility":117,"status":53,"city":118,"state":48,"zip":119,"country":57,"countryCode":58,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"University Hospital Ayr","Ayr","KA6 6DX",{"type":60,"coordinates":121},[122,123],-4.63393,55.46273,{"lat":123,"lon":122},[126,128],{"name":82,"role":46,"phone":127,"phoneExt":48,"email":48},"01563 825858",{"name":129,"role":42,"phone":48,"phoneExt":48,"email":48},"Lucy Scott",{"facility":131,"status":53,"city":132,"state":48,"zip":133,"country":57,"countryCode":58,"cosmosGeoPoint":134,"geoPoint":138,"contacts":139},"Basingstoke and North Hampshire Hospital","Basingstoke","RG24 9NA",{"type":60,"coordinates":135},[136,137],-1.08708,51.26249,{"lat":137,"lon":136},[140,142],{"name":82,"role":46,"phone":141,"phoneExt":48,"email":48},"01256 473202",{"name":143,"role":42,"phone":48,"phoneExt":48,"email":48},"Sanjay Raj",{"facility":145,"status":53,"city":146,"state":48,"zip":48,"country":57,"countryCode":58,"cosmosGeoPoint":147,"geoPoint":151,"contacts":152},"Bedford General Hospital","Bedford",{"type":60,"coordinates":148},[149,150],-0.46632,52.13459,{"lat":150,"lon":149},[153,155],{"name":82,"role":46,"phone":154,"phoneExt":48,"email":48},"01234 795924",{"name":156,"role":42,"phone":48,"phoneExt":48,"email":48},"Shahzeena Aslam",{"facility":158,"status":53,"city":159,"state":48,"zip":160,"country":57,"countryCode":58,"cosmosGeoPoint":161,"geoPoint":165,"contacts":166},"Royal Bournemouth Hospital","Bournemouth","BH7 7DW",{"type":60,"coordinates":162},[163,164],-1.8795,50.72048,{"lat":164,"lon":163},[167,169],{"name":82,"role":46,"phone":168,"phoneExt":48,"email":48},"01202704773",{"name":170,"role":42,"phone":48,"phoneExt":48,"email":48},"Maria Cidon",{"facility":172,"status":53,"city":173,"state":48,"zip":174,"country":57,"countryCode":58,"cosmosGeoPoint":175,"geoPoint":179,"contacts":180},"Bristol Haematology & Cancer Centre","Bristol","BS2 8ED",{"type":60,"coordinates":176},[177,178],-2.59665,51.45523,{"lat":178,"lon":177},[181,183],{"name":82,"role":46,"phone":182,"phoneExt":48,"email":48},"0117 342 6736",{"name":184,"role":42,"phone":48,"phoneExt":48,"email":48},"Jeremy Braybrooke",{"facility":186,"status":53,"city":187,"state":48,"zip":188,"country":57,"countryCode":58,"cosmosGeoPoint":189,"geoPoint":193,"contacts":194},"West Suffolk Hospital","Bury St Edmunds","IP33 2QZ",{"type":60,"coordinates":190},[191,192],0.71111,52.2463,{"lat":192,"lon":191},[195,197],{"name":82,"role":46,"phone":196,"phoneExt":48,"email":48},"01284 712763",{"name":198,"role":42,"phone":48,"phoneExt":48,"email":48},"Margaret Moody",{"facility":200,"status":53,"city":201,"state":48,"zip":202,"country":57,"countryCode":58,"cosmosGeoPoint":203,"geoPoint":207,"contacts":208},"Velindre Cancer Centre","Cardiff","CF14 2TL",{"type":60,"coordinates":204},[205,206],-3.18,51.48,{"lat":206,"lon":205},[209,211],{"name":82,"role":46,"phone":210,"phoneExt":48,"email":48},"02920615888",{"name":212,"role":42,"phone":48,"phoneExt":48,"email":48},"Annabel Borley",{"facility":214,"status":53,"city":215,"state":48,"zip":216,"country":57,"countryCode":58,"cosmosGeoPoint":217,"geoPoint":221,"contacts":222},"Colchester General Hospital","Colchester","CO4 5JL",{"type":60,"coordinates":218},[219,220],0.90421,51.88921,{"lat":220,"lon":219},[223,225],{"name":82,"role":46,"phone":224,"phoneExt":48,"email":48},"01206 745 355",{"name":226,"role":42,"phone":48,"phoneExt":48,"email":48},"MB Mukesh",{"facility":228,"status":53,"city":229,"state":48,"zip":230,"country":57,"countryCode":58,"cosmosGeoPoint":231,"geoPoint":235,"contacts":236},"Russells Hall Hospital","Dudley","DY1 2HQ",{"type":60,"coordinates":232},[233,234],-2.08333,52.5,{"lat":234,"lon":233},[237,239],{"name":82,"role":46,"phone":238,"phoneExt":48,"email":48},"01384 456111",{"name":240,"role":42,"phone":48,"phoneExt":48,"email":48},"Devanshi Tripathi",{"facility":242,"status":53,"city":243,"state":48,"zip":244,"country":57,"countryCode":58,"cosmosGeoPoint":245,"geoPoint":249,"contacts":250},"Hinchingbrooke Hospital","Huntingdon","PE29 6NT",{"type":60,"coordinates":246},[247,248],-0.18651,52.33049,{"lat":248,"lon":247},[251],{"name":252,"role":42,"phone":48,"phoneExt":48,"email":48},"Cheryl Palmer",{"facility":254,"status":53,"city":255,"state":48,"zip":256,"country":57,"countryCode":58,"cosmosGeoPoint":257,"geoPoint":261,"contacts":262},"Ipswich Hospital","Ipswich","IP4 5PD",{"type":60,"coordinates":258},[259,260],1.15545,52.05917,{"lat":260,"lon":259},[263],{"name":264,"role":42,"phone":48,"phoneExt":48,"email":48},"Ramachandran Venkitaraman",{"facility":266,"status":53,"city":267,"state":48,"zip":268,"country":57,"countryCode":58,"cosmosGeoPoint":269,"geoPoint":273,"contacts":274},"Kidderminster General Hospital","Kidderminster","DY11 6RJ",{"type":60,"coordinates":270},[271,272],-2.25,52.38819,{"lat":272,"lon":271},[275,277],{"name":82,"role":46,"phone":276,"phoneExt":48,"email":48},"01562 513275",{"name":278,"role":42,"phone":48,"phoneExt":48,"email":48},"Mark Churn",{"facility":280,"status":53,"city":281,"state":48,"zip":282,"country":57,"countryCode":58,"cosmosGeoPoint":283,"geoPoint":287,"contacts":288},"University Hospital Crosshouse","Kilmarnock","KA2 0BE",{"type":60,"coordinates":284},[285,286],-4.49581,55.61171,{"lat":286,"lon":285},[289,290],{"name":82,"role":46,"phone":127,"phoneExt":48,"email":48},{"name":129,"role":42,"phone":48,"phoneExt":48,"email":48},{"facility":292,"status":53,"city":293,"state":48,"zip":294,"country":57,"countryCode":58,"cosmosGeoPoint":295,"geoPoint":299,"contacts":300},"University College London Hospital","London","NW1 2PG",{"type":60,"coordinates":296},[297,298],-0.12574,51.50853,{"lat":298,"lon":297},[301,303],{"name":82,"role":46,"phone":302,"phoneExt":48,"email":48},"02034474741",{"name":304,"role":42,"phone":48,"phoneExt":48,"email":48},"Rebecca Roylance",{"facility":306,"status":53,"city":293,"state":48,"zip":307,"country":57,"countryCode":58,"cosmosGeoPoint":308,"geoPoint":310,"contacts":311},"Royal Free Hospital","NW3 2QG",{"type":60,"coordinates":309},[297,298],{"lat":298,"lon":297},[312,314],{"name":82,"role":46,"phone":313,"phoneExt":48,"email":48},"0207 794 0500",{"name":315,"role":42,"phone":48,"phoneExt":48,"email":48},"Jackie Newby",{"facility":317,"status":53,"city":318,"state":48,"zip":319,"country":57,"countryCode":58,"cosmosGeoPoint":320,"geoPoint":324,"contacts":325},"Mount Vernon Cancer Centre","Northwood","HA6 2RN",{"type":60,"coordinates":321},[322,323],-0.42454,51.61162,{"lat":323,"lon":322},[326],{"name":327,"role":42,"phone":48,"phoneExt":48,"email":48},"Stephanie Sutherland",{"facility":329,"status":53,"city":330,"state":48,"zip":331,"country":57,"countryCode":58,"cosmosGeoPoint":332,"geoPoint":336,"contacts":337},"Nottingham City Hospital","Nottingham","NG5 1PB",{"type":60,"coordinates":333},[334,335],-1.15047,52.9536,{"lat":335,"lon":334},[338,340],{"name":82,"role":46,"phone":339,"phoneExt":48,"email":48},"0115 969 1169",{"name":341,"role":42,"phone":48,"phoneExt":48,"email":48},"Stephen Chan",{"facility":343,"status":53,"city":344,"state":48,"zip":345,"country":57,"countryCode":58,"cosmosGeoPoint":346,"geoPoint":350,"contacts":351},"Churchill Hospital","Oxford","OX3 7LE",{"type":60,"coordinates":347},[348,349],-1.25596,51.75222,{"lat":349,"lon":348},[352,354],{"name":82,"role":46,"phone":353,"phoneExt":48,"email":48},"01865 572025",{"name":355,"role":42,"phone":48,"phoneExt":48,"email":48},"Nicola Levitt",{"facility":357,"status":53,"city":358,"state":48,"zip":359,"country":57,"countryCode":58,"cosmosGeoPoint":360,"geoPoint":364,"contacts":365},"Peterborough City Hospital","Peterborough","PE3 9GZ",{"type":60,"coordinates":361},[362,363],-0.24777,52.57364,{"lat":363,"lon":362},[366,368],{"name":82,"role":46,"phone":367,"phoneExt":48,"email":48},"01733 673167",{"name":369,"role":42,"phone":48,"phoneExt":48,"email":48},"Karen McAdam",{"facility":371,"status":53,"city":372,"state":48,"zip":373,"country":57,"countryCode":58,"cosmosGeoPoint":374,"geoPoint":378,"contacts":379},"Poole Hospital","Poole","BH15 2JB",{"type":60,"coordinates":375},[376,377],-1.98458,50.71429,{"lat":377,"lon":376},[380],{"name":381,"role":42,"phone":48,"phoneExt":48,"email":48},"Amit Chakrabarti",{"facility":383,"status":53,"city":384,"state":48,"zip":385,"country":57,"countryCode":58,"cosmosGeoPoint":386,"geoPoint":390,"contacts":391},"The Alexandra Hopsital","Redditch","B98 7",{"type":60,"coordinates":387},[388,389],-1.94569,52.3065,{"lat":389,"lon":388},[392,394],{"name":82,"role":46,"phone":393,"phoneExt":48,"email":48},"01527 505788",{"name":278,"role":42,"phone":48,"phoneExt":48,"email":48},{"facility":71,"status":53,"city":396,"state":48,"zip":397,"country":57,"countryCode":58,"cosmosGeoPoint":398,"geoPoint":402,"contacts":403},"Romford","RM7 OAG",{"type":60,"coordinates":399},[400,401],0.18582,51.57515,{"lat":401,"lon":400},[404,406],{"name":82,"role":46,"phone":405,"phoneExt":48,"email":48},"01708 435297",{"name":407,"role":42,"phone":48,"phoneExt":48,"email":48},"Emma Staples",{"facility":409,"status":53,"city":410,"state":48,"zip":411,"country":57,"countryCode":58,"cosmosGeoPoint":412,"geoPoint":416,"contacts":417},"Southampton General Hospital","Southampton","SO16 6YD",{"type":60,"coordinates":413},[414,415],-1.40428,50.90395,{"lat":415,"lon":414},[418,420],{"name":82,"role":46,"phone":419,"phoneExt":48,"email":48},"02381 204618",{"name":421,"role":42,"phone":48,"phoneExt":48,"email":48},"Ellen Copson",{"facility":423,"status":53,"city":424,"state":48,"zip":425,"country":57,"countryCode":58,"cosmosGeoPoint":426,"geoPoint":430,"contacts":431},"Singleton Hospital","Swansea","SA2 8QA",{"type":60,"coordinates":427},[428,429],-3.94323,51.62079,{"lat":429,"lon":428},[432],{"name":433,"role":42,"phone":48,"phoneExt":48,"email":48},"David Davies",{"facility":435,"status":53,"city":436,"state":48,"zip":437,"country":57,"countryCode":58,"cosmosGeoPoint":438,"geoPoint":442,"contacts":443},"Royal Hampshire County Hospital","Winchester","SO22 5DG",{"type":60,"coordinates":439},[440,441],-1.3187,51.06513,{"lat":441,"lon":440},[444,446],{"name":82,"role":46,"phone":445,"phoneExt":48,"email":48},"01962 824634",{"name":143,"role":42,"phone":48,"phoneExt":48,"email":48},{"facility":448,"status":53,"city":449,"state":48,"zip":450,"country":57,"countryCode":58,"cosmosGeoPoint":451,"geoPoint":455,"contacts":456},"Worcestershire Royal Hospital","Worcester","WR5 1DD",{"type":60,"coordinates":452},[453,454],-2.22001,52.18935,{"lat":454,"lon":453},[457,459],{"name":82,"role":46,"phone":458,"phoneExt":48,"email":48},"01905 733194",{"name":278,"role":42,"phone":48,"phoneExt":48,"email":48},{"type":42,"investigatorFullName":461,"investigatorTitle":462,"investigatorAffiliation":463,"oldNameTitle":48,"oldOrganization":48},"Prof. Jean Abraham","Professor","University of Cambridge",[465,468],{"name":466,"class":467},"AstraZeneca","INDUSTRY",{"name":469,"class":6},"Cancer Research UK","100297328","phase-2-platinum-and-polyadenosine-5diphosphoribose-polymerisation-inhibitor-for-neoadjuvant-treatment-of-triple-negative-breast-cancer-andor-germline-brca-positive-breast-cancer-100297328",false,"NCT03150576","Platinum and Polyadenosine 5'Diphosphoribose Polymerisation Inhibitor for Neoadjuvant Treatment of Triple Negative Breast Cancer and\u002For Germline BRCA Positive Breast Cancer","Randomised, Phase II\u002FIII, 3 Stage Trial to Evaluate the Safety and Efficacy of the Addition of Olaparib to Platinum-based Neoadjuvant Chemotherapy in Breast Cancer Patients With TNBC and\u002For gBRCA.","PARTNER","Inclusion Criteria:\n\n* Aged between 16 and 70.\n* Written informed consent, willing and able to comply with the Protocol for the duration of the trial including undergoing treatment and scheduled visits and examinations.\n* Histologically confirmed invasive breast cancer.\n* ER-negative\\*, and HER2-negative\\*\\* breast cancer (TNBC). Patients will be eligible with any PR status but PR expression must be scored.\n\nOR\n\n* Germline BRCA (gBRCA) mutation positive, HER2 negative, and PgR \u002F ER of any status.\n* T1, T2 or T3 tumours.\n* T4 tumour of any size with direct extension to (a) chest wall or (b) skin. OR Inflammatory carcinoma with tumour of any size. OR\n\nOther Locally Advanced Disease:\n\n* Involvement of ipsilateral large or fixed axillary lymph nodes, or infra or supraclavicular nodes (\\>10mm diameter or clinical N2 or N3) and primary breast tumour of any diameter.\n* Involvement of ipsilateral large or fixed axillary lymph nodes, or infra or supraclavicular nodes (\\>10mm diameter, or clinical N2 or N3), without a primary breast tumour identified, the presence of breast cancer in a Lymph Node (LN) must be histopathologically confirmed by LN biopsy.\n\nOR\n\nMultifocal tumour:\n\n\\- with at least one tumour with a size\\>10mm.\n\n* Patients with bilateral disease are eligible to enter the trial provided that both breast disease meets the above criteria.\n* Be fit to receive the trial chemotherapy regimen in the opinion of the responsible clinician:\n\nAdequate bone marrow, hepatic, and renal function. ECOG performance status of 0, or 1.\n\n* Treatment should be commenced within 6 weeks of the diagnostic biopsy. In uncommon circumstances, where medically acceptable, treatment is permitted to start within a maximum of 9 weeks of the diagnostic biopsy.\n* Availability of the Tumour Infiltrating Lymphocytes score is required.\n* Availability of CK 5\u002F6 and EGFR +\u002F- Androgen Receptor IHC score.\n* Availability of slides and paraffin embedded tissue blocks from pre-chemotherapy core biopsy and from primary surgical resection is required.\n* Women of child-bearing potential (WCBP), defined as not surgically sterilized or not post-menopausal for at least 24 consecutive months if age ≤55 year or 12 months if age \\>55 years, must have a negative serum or urine pregnancy test within 14 days prior to randomisation.\n* All WCBP and all sexually active male patients as well as their partners must be aware that they should not conceive during the treatment period and therefore should routinely use effective forms of contraception, throughout their participation in the trial and for at least 6 months after the last dose of trial treatment. Please follow the olaparib contraception guidelines.\n\nExclusion Criteria:\n\n* T0 tumour in absence of axillary node \\>10mm.\n* TNBC with a non-basal phenotype which strongly expresses Androgen Receptor.\n* Previous or concomitant chemotherapy or biological agents used for the treatment of cancer in the last 5 years.\n* Malignancy within the last 5 years except: adequately treated non-melanoma skin cancer; curatively treated in situ cancer of the cervix; ductal carcinoma in situ (DCIS); Stage 1, grade 1 endometrial carcinoma; or other solid tumours including lymphomas (without bone marrow involvement) curatively treated with no evidence of disease for ≥5 years.\n* Patients with myelodysplastic syndrome\u002Facute myeloid leukaemia.\n* Evidence of distant metastasis apparent prior to randomisation.\n* Patients with uncontrolled seizures.\n* Pre-existing sensory or motor neuropathy of CTCAE v4.03, grade ≥2.\n* Concomitant use of known potent CYP3A4 inhibitors and inducers. Consider wash-out periods.\n* Pregnant or breast feeding women.\n* Not suitable for neoadjuvant chemotherapy in the opinion of the responsible clinician.\n* Major surgery within 14 days of starting trial treatment and patients must have recovered from any effects of any major surgery.\n* Any evidence of other disease or any concomitant medical or psychiatric problems which in the opinion of the Investigator would prevent completion of treatment or follow-up. For example:\n\nEvidence of severe or uncontrolled cardiac disease Uncontrolled ventricular arrhythmia Recent myocardial infarction (within 12 months) Active infection including Hepatitis B, Hepatitis C and Human Immunodeficiency virus (HIV). Screening for chronic conditions is not required.\n\n* ECG with mean resting QTc \\>470 msec on 2 or more time points within a 24 hour period or family history of long QT syndrome.\n* Patients unable to swallow orally administered medication and patients with gastrointestinal disorders likely to interfere with absorption of the trial medication\n* Known hypersensitivity to olaparib, carboplatin, paclitaxel or their excipients (including cremophor).\n* Whole blood transfusions in the last 120 days prior to blood sampling for BRCA test as it may interfere with the results (packed red blood cells and platelet transfusions are acceptable).","ALL","16 Years","70 Years",{"count":482,"type":483},780,"ESTIMATED","INTERVENTIONAL",[486,487],"PHASE2","PHASE3","This neoadjuvant trial for patients with TNBC and\u002For gBRCA breast cancer, aims to investigate the safety and efficacy (improvement in pathological Complete Response at surgery) of concurrent platinum-based chemotherapy with olaparib an inhibitor of the PARP enzyme (PARPi).",[490],"Breast Cancer",[492,493,494,495,496],"Triple negative breast cancer","germline BRCA","platinum and PARP inhibitor","neoadjuvant chemotherapy","olaparib","2022-11-09",{"date":499,"type":500},"2022-11-14","ACTUAL",{"date":502,"type":48},"2016-05",{"date":504,"type":483},"2034-06",{"name":5,"class":6},30]